Bruton's agammaglobulinemia

P. LoGalbo, Norman Todd Ilowite, V. Bonagura, P. Lanzkowsky, J. Strober, M. Gandhi, I. R. Shenker, B. Gauthier, A. Battista

Research output: Contribution to journalArticle

Abstract

A 27-month-old male began having bronchitis and/or otitis media every one to two months and repeated episodes of diarrhea and urinary tract infections at about the age of 6 months. He was admitted with a one-day history of cough, fever and diarrhea. The physical examination revealed a slight fever, evidence of left sided pneumonia and hepatomegaly (7 cm BCM). There was also joint swelling, warmth and effusion. Levels of IgG, IgA and IgM were all very low. The history and the findings were characteristic of Bruton's agammaglobulinemia, an X-linked disease due to a failure of differentiation from pre-B cell to mature B cells. Children with this disorder are protected by transplacentally acquired maternal IgG until about 6 months of age and then usually develop pyogenic infections. With the exception of enteroviruses (e.g. polyomyelitis), they are not susceptible to viral infection. Pyogenic infections may be prevented by the IV administration of gammaglobulins. Methotrexate is useful for the control of the joint manifestations of the disease.

Original languageEnglish (US)
Pages (from-to)177-180
Number of pages4
JournalChildren's Hospital Quarterly
Volume6
Issue number3
StatePublished - 1995
Externally publishedYes

Fingerprint

Diarrhea
Fever
Immunoglobulin G
B-Lymphoid Precursor Cells
Hepatomegaly
Bronchitis
Joint Diseases
Enterovirus
Otitis Media
Virus Diseases
Infection
Cough
Methotrexate
Urinary Tract Infections
Immunoglobulin A
Physical Examination
Immunoglobulin M
Pneumonia
B-Lymphocytes
Joints

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

LoGalbo, P., Ilowite, N. T., Bonagura, V., Lanzkowsky, P., Strober, J., Gandhi, M., ... Battista, A. (1995). Bruton's agammaglobulinemia. Children's Hospital Quarterly, 6(3), 177-180.

Bruton's agammaglobulinemia. / LoGalbo, P.; Ilowite, Norman Todd; Bonagura, V.; Lanzkowsky, P.; Strober, J.; Gandhi, M.; Shenker, I. R.; Gauthier, B.; Battista, A.

In: Children's Hospital Quarterly, Vol. 6, No. 3, 1995, p. 177-180.

Research output: Contribution to journalArticle

LoGalbo, P, Ilowite, NT, Bonagura, V, Lanzkowsky, P, Strober, J, Gandhi, M, Shenker, IR, Gauthier, B & Battista, A 1995, 'Bruton's agammaglobulinemia', Children's Hospital Quarterly, vol. 6, no. 3, pp. 177-180.
LoGalbo P, Ilowite NT, Bonagura V, Lanzkowsky P, Strober J, Gandhi M et al. Bruton's agammaglobulinemia. Children's Hospital Quarterly. 1995;6(3):177-180.
LoGalbo, P. ; Ilowite, Norman Todd ; Bonagura, V. ; Lanzkowsky, P. ; Strober, J. ; Gandhi, M. ; Shenker, I. R. ; Gauthier, B. ; Battista, A. / Bruton's agammaglobulinemia. In: Children's Hospital Quarterly. 1995 ; Vol. 6, No. 3. pp. 177-180.
@article{76bc030a3c5c40f6aa6ee527f1e50a6a,
title = "Bruton's agammaglobulinemia",
abstract = "A 27-month-old male began having bronchitis and/or otitis media every one to two months and repeated episodes of diarrhea and urinary tract infections at about the age of 6 months. He was admitted with a one-day history of cough, fever and diarrhea. The physical examination revealed a slight fever, evidence of left sided pneumonia and hepatomegaly (7 cm BCM). There was also joint swelling, warmth and effusion. Levels of IgG, IgA and IgM were all very low. The history and the findings were characteristic of Bruton's agammaglobulinemia, an X-linked disease due to a failure of differentiation from pre-B cell to mature B cells. Children with this disorder are protected by transplacentally acquired maternal IgG until about 6 months of age and then usually develop pyogenic infections. With the exception of enteroviruses (e.g. polyomyelitis), they are not susceptible to viral infection. Pyogenic infections may be prevented by the IV administration of gammaglobulins. Methotrexate is useful for the control of the joint manifestations of the disease.",
author = "P. LoGalbo and Ilowite, {Norman Todd} and V. Bonagura and P. Lanzkowsky and J. Strober and M. Gandhi and Shenker, {I. R.} and B. Gauthier and A. Battista",
year = "1995",
language = "English (US)",
volume = "6",
pages = "177--180",
journal = "Children's Hospital Quarterly",
issn = "0899-5869",
publisher = "Kluwer/Plenum Publishers",
number = "3",

}

TY - JOUR

T1 - Bruton's agammaglobulinemia

AU - LoGalbo, P.

AU - Ilowite, Norman Todd

AU - Bonagura, V.

AU - Lanzkowsky, P.

AU - Strober, J.

AU - Gandhi, M.

AU - Shenker, I. R.

AU - Gauthier, B.

AU - Battista, A.

PY - 1995

Y1 - 1995

N2 - A 27-month-old male began having bronchitis and/or otitis media every one to two months and repeated episodes of diarrhea and urinary tract infections at about the age of 6 months. He was admitted with a one-day history of cough, fever and diarrhea. The physical examination revealed a slight fever, evidence of left sided pneumonia and hepatomegaly (7 cm BCM). There was also joint swelling, warmth and effusion. Levels of IgG, IgA and IgM were all very low. The history and the findings were characteristic of Bruton's agammaglobulinemia, an X-linked disease due to a failure of differentiation from pre-B cell to mature B cells. Children with this disorder are protected by transplacentally acquired maternal IgG until about 6 months of age and then usually develop pyogenic infections. With the exception of enteroviruses (e.g. polyomyelitis), they are not susceptible to viral infection. Pyogenic infections may be prevented by the IV administration of gammaglobulins. Methotrexate is useful for the control of the joint manifestations of the disease.

AB - A 27-month-old male began having bronchitis and/or otitis media every one to two months and repeated episodes of diarrhea and urinary tract infections at about the age of 6 months. He was admitted with a one-day history of cough, fever and diarrhea. The physical examination revealed a slight fever, evidence of left sided pneumonia and hepatomegaly (7 cm BCM). There was also joint swelling, warmth and effusion. Levels of IgG, IgA and IgM were all very low. The history and the findings were characteristic of Bruton's agammaglobulinemia, an X-linked disease due to a failure of differentiation from pre-B cell to mature B cells. Children with this disorder are protected by transplacentally acquired maternal IgG until about 6 months of age and then usually develop pyogenic infections. With the exception of enteroviruses (e.g. polyomyelitis), they are not susceptible to viral infection. Pyogenic infections may be prevented by the IV administration of gammaglobulins. Methotrexate is useful for the control of the joint manifestations of the disease.

UR - http://www.scopus.com/inward/record.url?scp=0029583454&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029583454&partnerID=8YFLogxK

M3 - Article

VL - 6

SP - 177

EP - 180

JO - Children's Hospital Quarterly

JF - Children's Hospital Quarterly

SN - 0899-5869

IS - 3

ER -