Bronchial Reactivity and Lung Function After World Trade Center Exposure

Thomas K. Aldrich, Jessica Weakley, Sean Dhar, Charles B. Hall, Tesha Crosse, Gisela I. Banauch, Michael D. Weiden, Gabriel Izbicki, Hillel W. Cohen, Aanchal Gupta, Camille King, Vasilios Christodoulou, Mayris P. Webber, Rachel Zeig-Owens, William Moir, Anna Nolan, Kerry J. Kelly, David J. Prezant

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background World Trade Center (WTC)-exposed rescue/recovery workers endured massive respiratory insult from inhalation of particulate matter and gases, resulting in respiratory symptoms, loss of lung function, and, for many, bronchial hyperreactivity (BHR). The persistence of respiratory symptoms and lung function abnormalities has been well-documented, whereas persistence of BHR has not been investigated. Methods A total of 173 WTC-exposed firefighters with bronchial reactivity measured within 2 years after September 11, 2001 (9/11) (baseline methacholine challenge test), were reevaluated in 2013 and 2014 (follow-up methacholine challenge test). FEV1 measurements were obtained from the late pre-9/11, early post-9/11, and late post-9/11 periods. Respiratory symptoms and corticosteroid treatment were recorded. Results Bronchial reactivity remained stable (within 1 doubling dilution) for most (n = 101, 58%). Sixteen of 28 (57%) with BHR (provocative concentration of methacholine producing a 20% decline in FEV1 <8 mg/mL) at baseline had BHR at follow-up, and an additional 27 of the 145 (19%) without BHR at baseline had BHR at follow-up. In multivariable models, we found that BHR baseline was strongly associated with BHR follow-up (OR, 6.46) and that BHR at follow-up was associated with an estimated 15.4 mL/y greater FEV1 decline than experienced by those without BHR at follow-up. Annual FEV1 decline was moderated by corticosteroid use. Conclusions Persistent BHR and its deleterious influence on lung function suggest a role for airway inflammation in perpetuation of WTC-associated airway disease. In future massive occupational exposure to inorganic dust/gases, we recommend early and serial pulmonary function testing, including measurements of bronchial reactivity, when possible, and inhaled corticosteroid therapy for those with symptoms or pulmonary function tests consistent with airway disease.

Original languageEnglish (US)
Pages (from-to)1333-1340
Number of pages8
JournalChest
Volume150
Issue number6
DOIs
StatePublished - Dec 1 2016

Fingerprint

Bronchial Hyperreactivity
Lung
Methacholine Chloride
Adrenal Cortex Hormones
Gases
Firefighters
Particulate Matter
Respiratory Function Tests
Occupational Exposure
Dust
Inhalation

Keywords

  • airway disease
  • asthma
  • epidemiology
  • firefighting
  • occupational diseases

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Bronchial Reactivity and Lung Function After World Trade Center Exposure. / Aldrich, Thomas K.; Weakley, Jessica; Dhar, Sean; Hall, Charles B.; Crosse, Tesha; Banauch, Gisela I.; Weiden, Michael D.; Izbicki, Gabriel; Cohen, Hillel W.; Gupta, Aanchal; King, Camille; Christodoulou, Vasilios; Webber, Mayris P.; Zeig-Owens, Rachel; Moir, William; Nolan, Anna; Kelly, Kerry J.; Prezant, David J.

In: Chest, Vol. 150, No. 6, 01.12.2016, p. 1333-1340.

Research output: Contribution to journalArticle

Aldrich, TK, Weakley, J, Dhar, S, Hall, CB, Crosse, T, Banauch, GI, Weiden, MD, Izbicki, G, Cohen, HW, Gupta, A, King, C, Christodoulou, V, Webber, MP, Zeig-Owens, R, Moir, W, Nolan, A, Kelly, KJ & Prezant, DJ 2016, 'Bronchial Reactivity and Lung Function After World Trade Center Exposure', Chest, vol. 150, no. 6, pp. 1333-1340. https://doi.org/10.1016/j.chest.2016.07.005
Aldrich TK, Weakley J, Dhar S, Hall CB, Crosse T, Banauch GI et al. Bronchial Reactivity and Lung Function After World Trade Center Exposure. Chest. 2016 Dec 1;150(6):1333-1340. https://doi.org/10.1016/j.chest.2016.07.005
Aldrich, Thomas K. ; Weakley, Jessica ; Dhar, Sean ; Hall, Charles B. ; Crosse, Tesha ; Banauch, Gisela I. ; Weiden, Michael D. ; Izbicki, Gabriel ; Cohen, Hillel W. ; Gupta, Aanchal ; King, Camille ; Christodoulou, Vasilios ; Webber, Mayris P. ; Zeig-Owens, Rachel ; Moir, William ; Nolan, Anna ; Kelly, Kerry J. ; Prezant, David J. / Bronchial Reactivity and Lung Function After World Trade Center Exposure. In: Chest. 2016 ; Vol. 150, No. 6. pp. 1333-1340.
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abstract = "Background World Trade Center (WTC)-exposed rescue/recovery workers endured massive respiratory insult from inhalation of particulate matter and gases, resulting in respiratory symptoms, loss of lung function, and, for many, bronchial hyperreactivity (BHR). The persistence of respiratory symptoms and lung function abnormalities has been well-documented, whereas persistence of BHR has not been investigated. Methods A total of 173 WTC-exposed firefighters with bronchial reactivity measured within 2 years after September 11, 2001 (9/11) (baseline methacholine challenge test), were reevaluated in 2013 and 2014 (follow-up methacholine challenge test). FEV1 measurements were obtained from the late pre-9/11, early post-9/11, and late post-9/11 periods. Respiratory symptoms and corticosteroid treatment were recorded. Results Bronchial reactivity remained stable (within 1 doubling dilution) for most (n = 101, 58{\%}). Sixteen of 28 (57{\%}) with BHR (provocative concentration of methacholine producing a 20{\%} decline in FEV1 <8 mg/mL) at baseline had BHR at follow-up, and an additional 27 of the 145 (19{\%}) without BHR at baseline had BHR at follow-up. In multivariable models, we found that BHR baseline was strongly associated with BHR follow-up (OR, 6.46) and that BHR at follow-up was associated with an estimated 15.4 mL/y greater FEV1 decline than experienced by those without BHR at follow-up. Annual FEV1 decline was moderated by corticosteroid use. Conclusions Persistent BHR and its deleterious influence on lung function suggest a role for airway inflammation in perpetuation of WTC-associated airway disease. In future massive occupational exposure to inorganic dust/gases, we recommend early and serial pulmonary function testing, including measurements of bronchial reactivity, when possible, and inhaled corticosteroid therapy for those with symptoms or pulmonary function tests consistent with airway disease.",
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AU - Aldrich, Thomas K.

AU - Weakley, Jessica

AU - Dhar, Sean

AU - Hall, Charles B.

AU - Crosse, Tesha

AU - Banauch, Gisela I.

AU - Weiden, Michael D.

AU - Izbicki, Gabriel

AU - Cohen, Hillel W.

AU - Gupta, Aanchal

AU - King, Camille

AU - Christodoulou, Vasilios

AU - Webber, Mayris P.

AU - Zeig-Owens, Rachel

AU - Moir, William

AU - Nolan, Anna

AU - Kelly, Kerry J.

AU - Prezant, David J.

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N2 - Background World Trade Center (WTC)-exposed rescue/recovery workers endured massive respiratory insult from inhalation of particulate matter and gases, resulting in respiratory symptoms, loss of lung function, and, for many, bronchial hyperreactivity (BHR). The persistence of respiratory symptoms and lung function abnormalities has been well-documented, whereas persistence of BHR has not been investigated. Methods A total of 173 WTC-exposed firefighters with bronchial reactivity measured within 2 years after September 11, 2001 (9/11) (baseline methacholine challenge test), were reevaluated in 2013 and 2014 (follow-up methacholine challenge test). FEV1 measurements were obtained from the late pre-9/11, early post-9/11, and late post-9/11 periods. Respiratory symptoms and corticosteroid treatment were recorded. Results Bronchial reactivity remained stable (within 1 doubling dilution) for most (n = 101, 58%). Sixteen of 28 (57%) with BHR (provocative concentration of methacholine producing a 20% decline in FEV1 <8 mg/mL) at baseline had BHR at follow-up, and an additional 27 of the 145 (19%) without BHR at baseline had BHR at follow-up. In multivariable models, we found that BHR baseline was strongly associated with BHR follow-up (OR, 6.46) and that BHR at follow-up was associated with an estimated 15.4 mL/y greater FEV1 decline than experienced by those without BHR at follow-up. Annual FEV1 decline was moderated by corticosteroid use. Conclusions Persistent BHR and its deleterious influence on lung function suggest a role for airway inflammation in perpetuation of WTC-associated airway disease. In future massive occupational exposure to inorganic dust/gases, we recommend early and serial pulmonary function testing, including measurements of bronchial reactivity, when possible, and inhaled corticosteroid therapy for those with symptoms or pulmonary function tests consistent with airway disease.

AB - Background World Trade Center (WTC)-exposed rescue/recovery workers endured massive respiratory insult from inhalation of particulate matter and gases, resulting in respiratory symptoms, loss of lung function, and, for many, bronchial hyperreactivity (BHR). The persistence of respiratory symptoms and lung function abnormalities has been well-documented, whereas persistence of BHR has not been investigated. Methods A total of 173 WTC-exposed firefighters with bronchial reactivity measured within 2 years after September 11, 2001 (9/11) (baseline methacholine challenge test), were reevaluated in 2013 and 2014 (follow-up methacholine challenge test). FEV1 measurements were obtained from the late pre-9/11, early post-9/11, and late post-9/11 periods. Respiratory symptoms and corticosteroid treatment were recorded. Results Bronchial reactivity remained stable (within 1 doubling dilution) for most (n = 101, 58%). Sixteen of 28 (57%) with BHR (provocative concentration of methacholine producing a 20% decline in FEV1 <8 mg/mL) at baseline had BHR at follow-up, and an additional 27 of the 145 (19%) without BHR at baseline had BHR at follow-up. In multivariable models, we found that BHR baseline was strongly associated with BHR follow-up (OR, 6.46) and that BHR at follow-up was associated with an estimated 15.4 mL/y greater FEV1 decline than experienced by those without BHR at follow-up. Annual FEV1 decline was moderated by corticosteroid use. Conclusions Persistent BHR and its deleterious influence on lung function suggest a role for airway inflammation in perpetuation of WTC-associated airway disease. In future massive occupational exposure to inorganic dust/gases, we recommend early and serial pulmonary function testing, including measurements of bronchial reactivity, when possible, and inhaled corticosteroid therapy for those with symptoms or pulmonary function tests consistent with airway disease.

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KW - asthma

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