@article{4b380640f5964c49aecfac15dbf5be62,
title = "Brief Report: Undercarboxylated Osteocalcin Is Associated With Cognition in Women With and Without HIV",
abstract = "Introduction:Bone loss and cognitive impairment are common in women living with HIV (WLWH) and are exacerbated by menopause. Bone-derived undercarboxylated osteocalcin (ucOCN) and sclerostin appear to influence cognition. The current study investigated whether the circulating levels of these 2 proteins are associated with cognition in midlife WLWH and demographically similar HIV seronegative women.Methods:Plasma samples from women enrolled in a musculoskeletal substudy within the Women's Interagency HIV Study were used to measure ucOCN and sclerostin. A neuropsychological (NP) test battery assessing executive function, processing speed, attention/working memory, learning, memory, verbal fluency, and motor function was administered within 6 months of musculoskeletal enrollment and every 2 years after (1-4 follow-up visits per participant). A series of generalized estimating equations were conducted to examine the association between biomarkers and NP performance at the initial assessment and over time in the total sample and in WLWH only. Primary predictors included biomarkers, time, and biomarker by time interactions. If the interaction terms were not significant, models were re-run without interactions.Results:Neither biomarker predicted changes in NP performance over time in the total sample or in WLWH. ucOCN was positively associated with executive function in the total sample and in WLWH and with motor skills in WLWH. ucOCN was negatively associated with attention/working memory in the total sample. There were no significant associations between sclerostin and NP performance.Conclusion:The current study suggests an association between bone-derived ucOCN and cognition in women with and without HIV infection.",
keywords = "bone, cognition, HIV, osteocalcin, sclerostin",
author = "Ross, {Ryan D.} and Olali, {Arnold Z.} and Qiuhu Shi and Hoover, {Donald R.} and Anjali Sharma and Weber, {Kathleen M.} and French, {Audrey L.} and Heather Mckay and Tien, {Phyllis C.} and Yin, {Michael T.} and Rubin, {Leah H.}",
note = "Funding Information: The contents of this publication are solely the responsibility of the authors and do not represent the official views of the National Institutes of Health (NIH). Data in this article were collected by the Women's Interagency HIV Study, now the MACS/WIHS Combined Cohort Study (MWCCS), and the National Institutes of Health through Grants R01AI095089 (M.T.Y.). Additional biomarker testing and data analyses for this article were supported by National Institute of Allergy and Infectious Diseases (NIAID) funding to the Chicago WIHS; 5U01AI034992-24 (Mardge Cohen, Audrey French). WIHS/MWCCS (Principal Investigators) for this project/article include: Bronx CRS (Kathryn Anastos and Anjali Sharma), U01-HL146204; U01- HL146193; Chicago-Cook County CRS (Mardge Cohen and Audrey French), U01-HL146240; Connie Wofsy Women's HIV Study, Northern California CRS (Bradley Aouizerat and Phyllis Tien), U01-HL146242; Data and biomarkers for this article were supported by funding from National Institute Of Allergy And Infectious Diseases (NIAID); the MWCCS is funded primarily by the National Heart, Lung, and Blood Institute (NHLBI), with additional cofunding from the Eunice Kennedy Shriver National Institute Of Child Health - Human Development (NICHD), National Institute Of Allergy And Infectious Diseases (NIAID), National Human Genome Research Institute (NHGRI), National Institute On Aging (NIA), National Institute Of Dental - Craniofacial Research (NIDCR), National Institute Of Allergy And Infectious Diseases (NIAID), National Institute Of Neurological Disorders And Stroke (NINDS), National Institute Of Mental Health (NIMH), National Institute On Drug Abuse (NIDA), National Institute Of Nursing Research (NINR), National Cancer Institute (NCI), National Institute on Alcohol Abuse and Alcoholism (NIAAA), National Institute on Deafness and Other Communication Disorders (NIDCD), and National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). Additional support was provided by the National Institutes of Health through Grants AI059884 (M.T.Y.) and the National Center for Advancing Translation Sciences, through Grant Number UL1TR001873. Funding Information: The contents of this publication are solely the responsibility of the authors and do not represent the official views of the National Institutes of Health (NIH). Data in this article were collected by the Women's Interagency HIV Study, now the MACS/WIHS Combined Cohort Study (MWCCS), and the National Institutes of Health through Grants R01AI095089 (M.T.Y.). Additional biomarker testing and data analyses for this article were supported by National Institute of Allergy and Infectious Diseases (NIAID) funding to the Chicago WIHS; 5U01AI034992-24 (Mardge Cohen, Audrey French). WIHS/MWCCS (Principal Investigators) for this project/article include: Bronx CRS (Kathryn Anastos and Anjali Sharma), U01-HL146204; U01- HL146193; Chicago-Cook County CRS (Mardge Cohen and Audrey French), U01-HL146240; Connie Wofsy Women's HIV Study, Northern California CRS (Bradley Aouizerat and Phyllis Tien), U01-HL146242; Data and biomarkers for this article were supported by funding from National Institute Of Allergy And Infectious Diseases (NIAID); the MWCCS is funded primarily by the National Heart, Lung, and Blood Institute (NHLBI), with additional cofunding from the Eunice Kennedy Shriver National Institute Of Child Health & Human Development (NICHD), National Institute Of Allergy And Infectious Diseases (NIAID), National Human Genome Research Institute (NHGRI), National Institute On Aging (NIA), National Institute Of Dental & Craniofacial Research (NIDCR), National Institute Of Allergy And Infectious Diseases (NIAID), National Institute Of Neurological Disorders And Stroke (NINDS), National Institute Of Mental Health (NIMH), National Institute On Drug Abuse (NIDA), National Institute Of Nursing Research (NINR), National Cancer Institute (NCI), National Institute on Alcohol Abuse and Alcoholism (NIAAA), National Institute on Deafness and Other Communication Disorders (NIDCD), and National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). Additional support was provided by the National Institutes of Health through Grants AI059884 (M.T.Y.) and the National Center for Advancing Translation Sciences, through Grant Number UL1TR001873. Publisher Copyright: {\textcopyright} 2022 Lippincott Williams and Wilkins. All rights reserved.",
year = "2022",
month = oct,
day = "1",
doi = "10.1097/QAI.0000000000003043",
language = "English (US)",
volume = "91",
pages = "162--167",
journal = "Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology",
issn = "1525-4135",
publisher = "Lippincott Williams and Wilkins",
number = "2",
}
