Brief report: Association of adipokines with bone mineral density in HIV-infected and HIV-uninfected women

Anjali Sharma, Yifei Ma, Rebecca Scherzer, Amber L. Wheeler, Mardge Cohen, Deborah R. Gustafson, Sheila M. Keating, Michael T. Yin, Phyllis C. Tien

Research output: Contribution to journalArticle

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Abstract

Background: HIV infection is associated with low bone mineral density (BMD) and alterations in adipokines, which may mediate the relationship between fat and bone. Objective: To evaluate the relationship of adiponectin and leptin with BMD in HIV-infected and uninfected women. Methods: We measured BMD over 5 years at the lumbar spine, total hip (TH), and femoral neck (FN) using dual-energy X-ray absorptiometry in 318 HIV-infected and 122 HIV-uninfected participants of the multicenter Women's Interagency HIV Study (WIHS). Total adiponectin and leptin were assayed on stored sera. Multivariable linear mixed models assessed the effects of adipokines and HIV status on BMD. Results: HIV-infected women had higher adiponectin (median 6.2 vs. 5.6 g/mL,) but lower leptin (11.7 vs. 19.8 ng/mL) levels at baseline (both P < 0.05) compared with HIV-uninfected women. HIV infection was associated with lower BMD at the lumbar spine (-0.074 g/cm 2), FN (-0.049 g/cm 2), and TH (-0.047 g/cm 2) (all P < 0.05) after adjusting for demographic, behavioral, and metabolic factors. HIV infection remained associated with lower BMD at each site, with little change in the effect sizes after additional adjustment for adiponectin or leptin. Among HIV-infected women, higher adiponectin was associated with lower TH BMD (-0.025 g/cm 2 per 10-fold increase, P 0.035), whereas higher leptin was associated with higher BMD at FN (+0.027 g/cm 2 per 10-fold increase, P 0.005) and TH (+0.019 g/cm 2, P 0.028). After multivariable adjustment, the adipokines showed little association with BMD at any site (P > 0.8 for adiponectin; P > 0.2 for leptin). Conclusions: Alterations in serum adiponectin and leptin do not explain low BMD in HIV-infected women.

Original languageEnglish (US)
Pages (from-to)433-437
Number of pages5
JournalJournal of Acquired Immune Deficiency Syndromes
Volume73
Issue number4
DOIs
StatePublished - Dec 1 2016

Fingerprint

Adipokines
Bone Density
Adiponectin
Leptin
HIV
Femur Neck
Photon Absorptiometry
Serum
HIV Infections
Hip
Linear Models
Spine
Fats
Bone and Bones

Keywords

  • adipokine
  • body composition
  • bone mineral density
  • HIV

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Brief report : Association of adipokines with bone mineral density in HIV-infected and HIV-uninfected women. / Sharma, Anjali; Ma, Yifei; Scherzer, Rebecca; Wheeler, Amber L.; Cohen, Mardge; Gustafson, Deborah R.; Keating, Sheila M.; Yin, Michael T.; Tien, Phyllis C.

In: Journal of Acquired Immune Deficiency Syndromes, Vol. 73, No. 4, 01.12.2016, p. 433-437.

Research output: Contribution to journalArticle

Sharma, Anjali ; Ma, Yifei ; Scherzer, Rebecca ; Wheeler, Amber L. ; Cohen, Mardge ; Gustafson, Deborah R. ; Keating, Sheila M. ; Yin, Michael T. ; Tien, Phyllis C. / Brief report : Association of adipokines with bone mineral density in HIV-infected and HIV-uninfected women. In: Journal of Acquired Immune Deficiency Syndromes. 2016 ; Vol. 73, No. 4. pp. 433-437.
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T2 - Association of adipokines with bone mineral density in HIV-infected and HIV-uninfected women

AU - Sharma, Anjali

AU - Ma, Yifei

AU - Scherzer, Rebecca

AU - Wheeler, Amber L.

AU - Cohen, Mardge

AU - Gustafson, Deborah R.

AU - Keating, Sheila M.

AU - Yin, Michael T.

AU - Tien, Phyllis C.

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N2 - Background: HIV infection is associated with low bone mineral density (BMD) and alterations in adipokines, which may mediate the relationship between fat and bone. Objective: To evaluate the relationship of adiponectin and leptin with BMD in HIV-infected and uninfected women. Methods: We measured BMD over 5 years at the lumbar spine, total hip (TH), and femoral neck (FN) using dual-energy X-ray absorptiometry in 318 HIV-infected and 122 HIV-uninfected participants of the multicenter Women's Interagency HIV Study (WIHS). Total adiponectin and leptin were assayed on stored sera. Multivariable linear mixed models assessed the effects of adipokines and HIV status on BMD. Results: HIV-infected women had higher adiponectin (median 6.2 vs. 5.6 g/mL,) but lower leptin (11.7 vs. 19.8 ng/mL) levels at baseline (both P < 0.05) compared with HIV-uninfected women. HIV infection was associated with lower BMD at the lumbar spine (-0.074 g/cm 2), FN (-0.049 g/cm 2), and TH (-0.047 g/cm 2) (all P < 0.05) after adjusting for demographic, behavioral, and metabolic factors. HIV infection remained associated with lower BMD at each site, with little change in the effect sizes after additional adjustment for adiponectin or leptin. Among HIV-infected women, higher adiponectin was associated with lower TH BMD (-0.025 g/cm 2 per 10-fold increase, P 0.035), whereas higher leptin was associated with higher BMD at FN (+0.027 g/cm 2 per 10-fold increase, P 0.005) and TH (+0.019 g/cm 2, P 0.028). After multivariable adjustment, the adipokines showed little association with BMD at any site (P > 0.8 for adiponectin; P > 0.2 for leptin). Conclusions: Alterations in serum adiponectin and leptin do not explain low BMD in HIV-infected women.

AB - Background: HIV infection is associated with low bone mineral density (BMD) and alterations in adipokines, which may mediate the relationship between fat and bone. Objective: To evaluate the relationship of adiponectin and leptin with BMD in HIV-infected and uninfected women. Methods: We measured BMD over 5 years at the lumbar spine, total hip (TH), and femoral neck (FN) using dual-energy X-ray absorptiometry in 318 HIV-infected and 122 HIV-uninfected participants of the multicenter Women's Interagency HIV Study (WIHS). Total adiponectin and leptin were assayed on stored sera. Multivariable linear mixed models assessed the effects of adipokines and HIV status on BMD. Results: HIV-infected women had higher adiponectin (median 6.2 vs. 5.6 g/mL,) but lower leptin (11.7 vs. 19.8 ng/mL) levels at baseline (both P < 0.05) compared with HIV-uninfected women. HIV infection was associated with lower BMD at the lumbar spine (-0.074 g/cm 2), FN (-0.049 g/cm 2), and TH (-0.047 g/cm 2) (all P < 0.05) after adjusting for demographic, behavioral, and metabolic factors. HIV infection remained associated with lower BMD at each site, with little change in the effect sizes after additional adjustment for adiponectin or leptin. Among HIV-infected women, higher adiponectin was associated with lower TH BMD (-0.025 g/cm 2 per 10-fold increase, P 0.035), whereas higher leptin was associated with higher BMD at FN (+0.027 g/cm 2 per 10-fold increase, P 0.005) and TH (+0.019 g/cm 2, P 0.028). After multivariable adjustment, the adipokines showed little association with BMD at any site (P > 0.8 for adiponectin; P > 0.2 for leptin). Conclusions: Alterations in serum adiponectin and leptin do not explain low BMD in HIV-infected women.

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KW - body composition

KW - bone mineral density

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