Brentuximab vedotin

Niels W.C.J. Van De Donk, Eugen Dhimolea

Research output: Contribution to journalReview articlepeer-review

93 Scopus citations

Abstract

Brentuximab vedotin (SGN-35; Adcetris®) is an anti-CD30 antibody conjugated via a protease-cleavable linker to the potent anti-microtubule agent monomethyl auristatin E (MMAE). Following binding to CD30, brentuximab vedotin is rapidly internalized and transported to lysosomes where MMAE is released and binds to tubulin, leading to cell cycle arrest and apoptosis. Several trials have shown durable antitumor activity with a manageable safety profile in patients with relapsed/refractory Hodgkin lymphoma, systemic anaplastic large cell lymphoma or primary cutaneous CD30-positive lymphoproliferative disorders. Peripheral sensory neuropathy is a significant adverse event associated with brentuximab vedotin administration. Neuropathy symptoms are cumulative and dose-related. Multiple ongoing trials are currently evaluating brentuximab vedotin alone or in combination with other agents in relapsed/ refractory patients, as well as patients with newly diagnosed disease.

Original languageEnglish (US)
Pages (from-to)458-465
Number of pages8
JournalmAbs
Volume4
Issue number4
DOIs
StatePublished - 2012
Externally publishedYes

Keywords

  • Anaplastic large cell lymphoma
  • Brentuximab vedotin
  • CD30
  • Hodgkin lymphoma
  • Immunotherapy
  • Monoclonal antibody

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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