BRCA1 gene sequence variation in centenarians

Jan Vijg, Thomas Perls, Claudio Franceschi, Nathalie J. Van Orsouw

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

With the ample gene sequence information that has become available with the human genome project virtually completed, it has become possible to identify functional gene variants and their frequencies in elderly populations with different aging-related characteristics. Such a genetic epidemiological approach could lead to new insights with respect to the basic mechanisms of aging and longevity as well as the identification of new targets to prevent or retard some of the late-age adverse effects. Using our recently developed two-dimensional gene scanning (TDGS) technology platform we demonstrate the feasibility of this approach by screening two different populations of centenarians for polymorphic variation in the BRCA1 breast cancer susceptibility gene, one of the many genes involved in genome maintenance. The initial results obtained with this approach suggest differences in BRCA1 genotype frequencies between the centenarian populations and controls.

Original languageEnglish (US)
Pages (from-to)85-96
Number of pages12
JournalAnnals of the New York Academy of Sciences
Volume928
StatePublished - 2001
Externally publishedYes

Fingerprint

BRCA1 Gene
Genes
Human Genome Project
Population Control
Neoplasm Genes
Population
Aging of materials
Genotype
Maintenance
Genome
Breast Neoplasms
Technology
Gene
Screening
Scanning

Keywords

  • 2-D gene scanning
  • Allelic variants
  • BRCA1
  • Centenarians
  • Genome instability

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Vijg, J., Perls, T., Franceschi, C., & Van Orsouw, N. J. (2001). BRCA1 gene sequence variation in centenarians. Annals of the New York Academy of Sciences, 928, 85-96.

BRCA1 gene sequence variation in centenarians. / Vijg, Jan; Perls, Thomas; Franceschi, Claudio; Van Orsouw, Nathalie J.

In: Annals of the New York Academy of Sciences, Vol. 928, 2001, p. 85-96.

Research output: Contribution to journalArticle

Vijg, J, Perls, T, Franceschi, C & Van Orsouw, NJ 2001, 'BRCA1 gene sequence variation in centenarians', Annals of the New York Academy of Sciences, vol. 928, pp. 85-96.
Vijg, Jan ; Perls, Thomas ; Franceschi, Claudio ; Van Orsouw, Nathalie J. / BRCA1 gene sequence variation in centenarians. In: Annals of the New York Academy of Sciences. 2001 ; Vol. 928. pp. 85-96.
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