Brainstem nutrient sensing in the nucleus of the solitary tract inhibits feeding

Clemence Blouet, Gary J. Schwartz

Research output: Contribution to journalArticle

71 Scopus citations

Abstract

Direct detection of circulating nutrients by the central nervous system has been implicated in the regulation of energy balance, and the mediobasal hypothalamus is considered as the primary sensing site mediating these effects. Neurons sensitive to energyrelated signals have also been identified outside the hypothalamus, particularly within the caudomedial nucleus of the solitary tract (cmNTS) in brainstem, but the consequences of direct cmNTS nutrient detection on energy balance remain poorly characterized. Here we determined the behavioral and metabolic consequences of direct L-leucine detection by the cmNTS and investigated the intracellular signaling and neurochemical pathways implicated in cmNTS L-leucine sensing in rats. Our results support the distributed nature of central nutrient detection, evidence a role for the cmNTS S6K1 pathway in the regulation of meal size and body weight, and suggest that the cmNTS integrates direct cmNTS nutrient detection with gut-derived, descending forebrain, and adiposity signals of energy availability to regulate food intake.

Original languageEnglish (US)
Pages (from-to)579-587
Number of pages9
JournalCell metabolism
Volume16
Issue number5
DOIs
StatePublished - Nov 7 2012

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cell Biology

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