Brainstem integrative function in the central nervous system control of food intake

Research output: Chapter in Book/Report/Conference proceedingChapter

35 Citations (Scopus)

Abstract

The caudal brainstem lies at a critical nexus in the neural hierarchy that helps determine the negative feedback control of ingestion. It is the first central nervous system site that receives neural input from vagal and nonvagal visceral afferents that convey not only meal-related signals from postoral sites reflecting chemical, mechanical and nutrient properties of ingested foods, but also responses to nutrient stimulated peptides and neurotransmitters via extrinsic gut afferent receptors. In addition, the circumventricular area postrema (AP) affords the caudal brainstem access to circulating factors that are released during a meal, as well as to adiposity hormones that reflect the availability of stored nutrients. Brainstem neurons themselves express eating modulatory neuropeptides as well as their cognate receptors, raising the possibility that local ligand-receptor interactions contribute to the neural basis of eating behavior. Finally, forebrain hypothalamic projections extend to brainstem neurons that also respond to humoral and meal-related post-oral signals from peripheral gut afferents, providing critical descending influences in the negative feedback control of food intake [1]. This article characterizes recent advances in our understanding of how peripheral, brainstem-intrinsic and descending forebrain influences may converge in the caudal brainstem to reduce food intake, with a focus on their roles in the control of meal size.

Original languageEnglish (US)
Title of host publicationFrontiers in Eating and Weight Regulation
PublisherS. Karger AG
Pages141-151
Number of pages11
Volume63
ISBN (Print)9783805593014, 9783805593007
DOIs
StatePublished - Dec 10 2009

Fingerprint

Neurology
Nutrients
Brain Stem
Central Nervous System
Eating
Neurons
Feedback control
Meals
Feedback
Food
Prosencephalon
Neuropeptides
Neurotransmitter Agents
Visceral Afferents
Availability
Hormones
Area Postrema
Ligands
Peptides
Adiposity

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Schwartz, G. J. (2009). Brainstem integrative function in the central nervous system control of food intake. In Frontiers in Eating and Weight Regulation (Vol. 63, pp. 141-151). S. Karger AG. https://doi.org/10.1159/000264402

Brainstem integrative function in the central nervous system control of food intake. / Schwartz, Gary J.

Frontiers in Eating and Weight Regulation. Vol. 63 S. Karger AG, 2009. p. 141-151.

Research output: Chapter in Book/Report/Conference proceedingChapter

Schwartz, GJ 2009, Brainstem integrative function in the central nervous system control of food intake. in Frontiers in Eating and Weight Regulation. vol. 63, S. Karger AG, pp. 141-151. https://doi.org/10.1159/000264402
Schwartz GJ. Brainstem integrative function in the central nervous system control of food intake. In Frontiers in Eating and Weight Regulation. Vol. 63. S. Karger AG. 2009. p. 141-151 https://doi.org/10.1159/000264402
Schwartz, Gary J. / Brainstem integrative function in the central nervous system control of food intake. Frontiers in Eating and Weight Regulation. Vol. 63 S. Karger AG, 2009. pp. 141-151
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