Brain stimulation techniques in the treatment of obsessive-compulsive disorder

Current and future directions

Bernardo Dell'Osso, Alfredo Carlo Altamura, Andrea Allen, Eric Hollander

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Recent studies on the epidemiology of obsessive-compulsive disorder (OCD) estimate 50 million patients suffer from OCD worldwide, thus making it a global problem. The treatment of OCD has changed substantially over the last 2 decades following the introduction of selective serotonin reuptake inhibitors, which provide symptom improvement in ∼60% of patients. However, some patients remain resistant to the standard pharmacologic and behavioral treatments. Although some treatment-resistant patients respond to pharmacologic augmentations, others do not, and there is evidence that some of the most severe cases benefit from treatment with neurosurgical interventions. Besides pharmacologic, behavioral, and neurosurgical approaches, different brain stimulation methods-transcranial magnetic stimulation, deep brain stimulation, and electroconvulsive therapy-have been investigated in treatment-resistant patients with OCD. However, available data about the use of these techniques in OCD treatment are quite limited in terms of sample size and study design, given the difficulty in conducting standard blinded trials for these procedures. In addition, none of the mentioned treatments have received Food and Drug Administration approval for the treatment of OCD. Nevertheless, promising findings regarding efficacy, tolerability, and non-invasiveness and/or reversibility of these techniques have increased interest in investigating their use in treatment-resistant OCD.

Original languageEnglish (US)
JournalCNS Spectrums
Volume10
Issue number12
StatePublished - Dec 2005
Externally publishedYes

Fingerprint

Obsessive-Compulsive Disorder
Brain
Therapeutics
Drug Approval
Direction compound
Electroconvulsive Therapy
Deep Brain Stimulation
Transcranial Magnetic Stimulation
Serotonin Uptake Inhibitors
United States Food and Drug Administration
Sample Size
Epidemiology

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology

Cite this

Brain stimulation techniques in the treatment of obsessive-compulsive disorder : Current and future directions. / Dell'Osso, Bernardo; Altamura, Alfredo Carlo; Allen, Andrea; Hollander, Eric.

In: CNS Spectrums, Vol. 10, No. 12, 12.2005.

Research output: Contribution to journalArticle

Dell'Osso, Bernardo ; Altamura, Alfredo Carlo ; Allen, Andrea ; Hollander, Eric. / Brain stimulation techniques in the treatment of obsessive-compulsive disorder : Current and future directions. In: CNS Spectrums. 2005 ; Vol. 10, No. 12.
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