Brain metastasis in two patients with stage IA papillary serous carcinoma of the uterus

Deepa M. Narasimhulu; Neekianund Khulpateea; Keith Meritz; Yiquing Xu

doi:10.1016/j.gore.2015.04.002

Brain metastasis in two patients with stage IA papillary serous carcinoma of the uterus

Deepa M. Narasimhulu, Neekianund Khulpateea, Keith Meritz, Yiquing Xu

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

We report two cases of brain metastasis in patients initially diagnosed with extremely early stage UPSC after extensive staging surgery. They did not receive either adjuvant chemotherapy or adjuvant pelvic or vaginal cuff radiation. At the same time that these patients were diagnosed with systemic metastasis, they both had a local "drop" metastasis in the vulva or the vaginal cuff. After the initial response to palliative chemotherapy, they both developed brain metastasis. The pattern of recurrence with the lack of adjuvant treatment underscores the urgent need in further evaluation of the potential benefits of adjuvant treatment, including chemotherapy and possibly in combination with radiation in this highly aggressive disease.

Original language	English (US)
Pages (from-to)	1-4
Number of pages	4
Journal	Gynecologic Oncology Reports
Volume	13
DOIs	https://doi.org/10.1016/j.gore.2015.04.002
State	Published - Aug 1 2015
Externally published	Yes

Keywords

Adjuvant chemotherapy
Brain metastasis
Papillary serous carcinoma of the uterus
Pelvic radiation
Vaginal cuff radiation

ASJC Scopus subject areas

Oncology
Obstetrics and Gynecology

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10.1016/j.gore.2015.04.002

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title = "Brain metastasis in two patients with stage IA papillary serous carcinoma of the uterus",

abstract = "We report two cases of brain metastasis in patients initially diagnosed with extremely early stage UPSC after extensive staging surgery. They did not receive either adjuvant chemotherapy or adjuvant pelvic or vaginal cuff radiation. At the same time that these patients were diagnosed with systemic metastasis, they both had a local {"}drop{"} metastasis in the vulva or the vaginal cuff. After the initial response to palliative chemotherapy, they both developed brain metastasis. The pattern of recurrence with the lack of adjuvant treatment underscores the urgent need in further evaluation of the potential benefits of adjuvant treatment, including chemotherapy and possibly in combination with radiation in this highly aggressive disease.",

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AU - Narasimhulu, Deepa M.

AU - Khulpateea, Neekianund

AU - Meritz, Keith

AU - Xu, Yiquing

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Y1 - 2015/8/1

N2 - We report two cases of brain metastasis in patients initially diagnosed with extremely early stage UPSC after extensive staging surgery. They did not receive either adjuvant chemotherapy or adjuvant pelvic or vaginal cuff radiation. At the same time that these patients were diagnosed with systemic metastasis, they both had a local "drop" metastasis in the vulva or the vaginal cuff. After the initial response to palliative chemotherapy, they both developed brain metastasis. The pattern of recurrence with the lack of adjuvant treatment underscores the urgent need in further evaluation of the potential benefits of adjuvant treatment, including chemotherapy and possibly in combination with radiation in this highly aggressive disease.

AB - We report two cases of brain metastasis in patients initially diagnosed with extremely early stage UPSC after extensive staging surgery. They did not receive either adjuvant chemotherapy or adjuvant pelvic or vaginal cuff radiation. At the same time that these patients were diagnosed with systemic metastasis, they both had a local "drop" metastasis in the vulva or the vaginal cuff. After the initial response to palliative chemotherapy, they both developed brain metastasis. The pattern of recurrence with the lack of adjuvant treatment underscores the urgent need in further evaluation of the potential benefits of adjuvant treatment, including chemotherapy and possibly in combination with radiation in this highly aggressive disease.

KW - Adjuvant chemotherapy

KW - Brain metastasis

KW - Papillary serous carcinoma of the uterus

KW - Pelvic radiation

KW - Vaginal cuff radiation

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Brain metastasis in two patients with stage IA papillary serous carcinoma of the uterus

Abstract

Keywords

ASJC Scopus subject areas

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