Brain metabolites B1-corrected proton T1 mapping in the rhesus macaque at 3 T

Songtao Liu, Roman Fleysher, Lazar Fleysher, Chan Gyu Joo, Eva Maria Ratai, R. Gilberto González, Oded Gonen

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The accuracy of metabolic quantification in MR spectroscopy is limited by the unknown radiofrequency field and T1. To address both issues in proton (1H) MR spectroscopy, we obtained radiofrequency field-corrected T1 maps of N-acetylaspartate, choline, and creatine in five healthy rhesus macaques at 3 T. For efficient use of the 4 hour experiment, we used a new three-point protocol that optimizes the precision of T1 in three-dimensional 1H-MR spectroscopy localization for extensive, ∼30%, brain coverage at 0.6 × 0.6 × 0.5 cm 3 = 180-μL spatial resolution. The resulting mean T1s in 700 voxels were N-acetylaspartate = 1232 ± 44, creatine = 1238 ± 23 and choline = 1107 ± 56 ms (mean ± standard error of the mean). Their histograms from all 140 voxels in each animal were similar in position and shape, characterized by standard errors of the mean of the full width at half maximum divided by their means of better than 8%. Regional gray matter N- acetylaspartate, choline, and creatine T1s (1333 ± 43, 1265 ± 52, and 1131 ± 28 ms) were 5-10% longer than white matter: 1188 ± 34, 1201 ± 24, and 1082 ± 50 ms (statistically significant for the N-acetylaspartate only), all within 10% of the corresponding published values in the human brain.

Original languageEnglish (US)
Pages (from-to)865-871
Number of pages7
JournalMagnetic Resonance in Medicine
Volume63
Issue number4
DOIs
StatePublished - May 2010
Externally publishedYes

Fingerprint

Macaca mulatta
Creatine
Protons
Choline
Magnetic Resonance Spectroscopy
Brain
N-acetylaspartate

Keywords

  • B mapping
  • Brain metabolites
  • Brain MR spectroscopy
  • Longitudinal relaxation time
  • Rhesus macaque
  • T

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Medicine(all)

Cite this

Liu, S., Fleysher, R., Fleysher, L., Joo, C. G., Ratai, E. M., González, R. G., & Gonen, O. (2010). Brain metabolites B1-corrected proton T1 mapping in the rhesus macaque at 3 T. Magnetic Resonance in Medicine, 63(4), 865-871. https://doi.org/10.1002/mrm.22270

Brain metabolites B1-corrected proton T1 mapping in the rhesus macaque at 3 T. / Liu, Songtao; Fleysher, Roman; Fleysher, Lazar; Joo, Chan Gyu; Ratai, Eva Maria; González, R. Gilberto; Gonen, Oded.

In: Magnetic Resonance in Medicine, Vol. 63, No. 4, 05.2010, p. 865-871.

Research output: Contribution to journalArticle

Liu, S, Fleysher, R, Fleysher, L, Joo, CG, Ratai, EM, González, RG & Gonen, O 2010, 'Brain metabolites B1-corrected proton T1 mapping in the rhesus macaque at 3 T', Magnetic Resonance in Medicine, vol. 63, no. 4, pp. 865-871. https://doi.org/10.1002/mrm.22270
Liu, Songtao ; Fleysher, Roman ; Fleysher, Lazar ; Joo, Chan Gyu ; Ratai, Eva Maria ; González, R. Gilberto ; Gonen, Oded. / Brain metabolites B1-corrected proton T1 mapping in the rhesus macaque at 3 T. In: Magnetic Resonance in Medicine. 2010 ; Vol. 63, No. 4. pp. 865-871.
@article{0681e6eff4f44b62b2ac80cf5e40b2b2,
title = "Brain metabolites B1-corrected proton T1 mapping in the rhesus macaque at 3 T",
abstract = "The accuracy of metabolic quantification in MR spectroscopy is limited by the unknown radiofrequency field and T1. To address both issues in proton (1H) MR spectroscopy, we obtained radiofrequency field-corrected T1 maps of N-acetylaspartate, choline, and creatine in five healthy rhesus macaques at 3 T. For efficient use of the 4 hour experiment, we used a new three-point protocol that optimizes the precision of T1 in three-dimensional 1H-MR spectroscopy localization for extensive, ∼30{\%}, brain coverage at 0.6 × 0.6 × 0.5 cm 3 = 180-μL spatial resolution. The resulting mean T1s in 700 voxels were N-acetylaspartate = 1232 ± 44, creatine = 1238 ± 23 and choline = 1107 ± 56 ms (mean ± standard error of the mean). Their histograms from all 140 voxels in each animal were similar in position and shape, characterized by standard errors of the mean of the full width at half maximum divided by their means of better than 8{\%}. Regional gray matter N- acetylaspartate, choline, and creatine T1s (1333 ± 43, 1265 ± 52, and 1131 ± 28 ms) were 5-10{\%} longer than white matter: 1188 ± 34, 1201 ± 24, and 1082 ± 50 ms (statistically significant for the N-acetylaspartate only), all within 10{\%} of the corresponding published values in the human brain.",
keywords = "B mapping, Brain metabolites, Brain MR spectroscopy, Longitudinal relaxation time, Rhesus macaque, T",
author = "Songtao Liu and Roman Fleysher and Lazar Fleysher and Joo, {Chan Gyu} and Ratai, {Eva Maria} and Gonz{\'a}lez, {R. Gilberto} and Oded Gonen",
year = "2010",
month = "5",
doi = "10.1002/mrm.22270",
language = "English (US)",
volume = "63",
pages = "865--871",
journal = "Magnetic Resonance in Medicine",
issn = "0740-3194",
publisher = "John Wiley and Sons Inc.",
number = "4",

}

TY - JOUR

T1 - Brain metabolites B1-corrected proton T1 mapping in the rhesus macaque at 3 T

AU - Liu, Songtao

AU - Fleysher, Roman

AU - Fleysher, Lazar

AU - Joo, Chan Gyu

AU - Ratai, Eva Maria

AU - González, R. Gilberto

AU - Gonen, Oded

PY - 2010/5

Y1 - 2010/5

N2 - The accuracy of metabolic quantification in MR spectroscopy is limited by the unknown radiofrequency field and T1. To address both issues in proton (1H) MR spectroscopy, we obtained radiofrequency field-corrected T1 maps of N-acetylaspartate, choline, and creatine in five healthy rhesus macaques at 3 T. For efficient use of the 4 hour experiment, we used a new three-point protocol that optimizes the precision of T1 in three-dimensional 1H-MR spectroscopy localization for extensive, ∼30%, brain coverage at 0.6 × 0.6 × 0.5 cm 3 = 180-μL spatial resolution. The resulting mean T1s in 700 voxels were N-acetylaspartate = 1232 ± 44, creatine = 1238 ± 23 and choline = 1107 ± 56 ms (mean ± standard error of the mean). Their histograms from all 140 voxels in each animal were similar in position and shape, characterized by standard errors of the mean of the full width at half maximum divided by their means of better than 8%. Regional gray matter N- acetylaspartate, choline, and creatine T1s (1333 ± 43, 1265 ± 52, and 1131 ± 28 ms) were 5-10% longer than white matter: 1188 ± 34, 1201 ± 24, and 1082 ± 50 ms (statistically significant for the N-acetylaspartate only), all within 10% of the corresponding published values in the human brain.

AB - The accuracy of metabolic quantification in MR spectroscopy is limited by the unknown radiofrequency field and T1. To address both issues in proton (1H) MR spectroscopy, we obtained radiofrequency field-corrected T1 maps of N-acetylaspartate, choline, and creatine in five healthy rhesus macaques at 3 T. For efficient use of the 4 hour experiment, we used a new three-point protocol that optimizes the precision of T1 in three-dimensional 1H-MR spectroscopy localization for extensive, ∼30%, brain coverage at 0.6 × 0.6 × 0.5 cm 3 = 180-μL spatial resolution. The resulting mean T1s in 700 voxels were N-acetylaspartate = 1232 ± 44, creatine = 1238 ± 23 and choline = 1107 ± 56 ms (mean ± standard error of the mean). Their histograms from all 140 voxels in each animal were similar in position and shape, characterized by standard errors of the mean of the full width at half maximum divided by their means of better than 8%. Regional gray matter N- acetylaspartate, choline, and creatine T1s (1333 ± 43, 1265 ± 52, and 1131 ± 28 ms) were 5-10% longer than white matter: 1188 ± 34, 1201 ± 24, and 1082 ± 50 ms (statistically significant for the N-acetylaspartate only), all within 10% of the corresponding published values in the human brain.

KW - B mapping

KW - Brain metabolites

KW - Brain MR spectroscopy

KW - Longitudinal relaxation time

KW - Rhesus macaque

KW - T

UR - http://www.scopus.com/inward/record.url?scp=77950601273&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77950601273&partnerID=8YFLogxK

U2 - 10.1002/mrm.22270

DO - 10.1002/mrm.22270

M3 - Article

C2 - 20373387

AN - SCOPUS:77950601273

VL - 63

SP - 865

EP - 871

JO - Magnetic Resonance in Medicine

JF - Magnetic Resonance in Medicine

SN - 0740-3194

IS - 4

ER -