Brain glucose metabolism and its relation to amyloid load in middle-aged adults with childhood-onset epilepsy

TACOE Study Group

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Uncomplicated childhood-onset epilepsy is associated with increased brain amyloid load at late middle age, but its possible association with Alzheimer-type neurodegenerative processes is unclear. After 50-year follow-up, 42 childhood onset epilepsy subjects and 45 matched controls were investigated with [18F]fluorodeoxyglucose PET. There were no significant differences between the subjects and controls, but higher [18F]fluorodeoxyglucose uptake was associated with a higher local amyloid load (as measured with [11C]PIB PET) in the prefrontal cortex, parietal cortex, and posterior cingulate/precuneus in subjects but not in controls. These findings parallel reported observations in cognitively normal individuals with increased brain amyloid accumulation who are at risk for future Alzheimer's disease.

Original languageEnglish (US)
Pages (from-to)69-72
Number of pages4
JournalEpilepsy Research
Volume137
DOIs
StatePublished - Nov 2017

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Keywords

  • Aging
  • Alzheimer's
  • Epilepsy
  • Imaging
  • Positron emission tomography

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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