Bradyzoite development

Research output: Chapter in Book/Report/Conference proceedingChapter

19 Citations (Scopus)

Abstract

Investigations into bradyzoite biology and the differentiation of tachyzoites into bradyzoites have been accelerated by the development of in vitro techniques to study and produce bradyzoites, as well as by the genetic tools that exist for the manipulation of T. gondii. T. gondii is a ubiquitous protozoan parasite of mammals and birds. It belongs to the phylum Apicomplexa, which includes other important pathogens such as Plasmodium, Eimeria, Cyclospora, Babesia, and Cryptosporidium. Toxoplasma gondii has three infectious stages: tachyzoites, bradyzoites, and sporozoites. Infection is acquired either by ingestion of under cooked meat harboring tissue cysts or by the ingestion of food contaminated with oocysts. Bradyzoites contained in cysts are refractory to most chemotherapeutic agents used for treatment of toxoplasmosis, and tissue cysts are produced in any animal capable of being infected with T. gondii. The persistence and reactivation of bradyzoite forms is a major cause of disease in humans. In most individuals, acute infection with T. gondii is asymptomatic or causes mild symptoms similar to a self-limited mononucleosis-like syndrome. If an immunologically naïve pregnant woman is infected, transmission of this parasite to the fetus can occur with the development of a congenital infection that can result in a fetopathy and a relapsing chorioretinitis. © 2007

Original languageEnglish (US)
Title of host publicationToxoplasma Gondii
PublisherElsevier Ltd
Pages341-366
Number of pages26
ISBN (Print)9780123695420
DOIs
StatePublished - 2007

Fingerprint

bradyzoites
Cysts
Toxoplasma gondii
Toxoplasmosis
Toxoplasma
tachyzoites
Parasites
Cyclospora
Eating
Chorioretinitis
Apicomplexa
Babesia
Eimeria
Sporozoites
Cryptosporidium
Plasmodium
Oocysts
ingestion
infection
Infection

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

Cite this

Weiss, L. M., & Kim, K. (2007). Bradyzoite development. In Toxoplasma Gondii (pp. 341-366). Elsevier Ltd. https://doi.org/10.1016/B978-012369542-0/50015-5

Bradyzoite development. / Weiss, Louis M.; Kim, K.

Toxoplasma Gondii. Elsevier Ltd, 2007. p. 341-366.

Research output: Chapter in Book/Report/Conference proceedingChapter

Weiss, LM & Kim, K 2007, Bradyzoite development. in Toxoplasma Gondii. Elsevier Ltd, pp. 341-366. https://doi.org/10.1016/B978-012369542-0/50015-5
Weiss LM, Kim K. Bradyzoite development. In Toxoplasma Gondii. Elsevier Ltd. 2007. p. 341-366 https://doi.org/10.1016/B978-012369542-0/50015-5
Weiss, Louis M. ; Kim, K. / Bradyzoite development. Toxoplasma Gondii. Elsevier Ltd, 2007. pp. 341-366
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