Bradyzoite Development

Laura J. Knoll; Tadakimi Tomita; Louis M. Weiss

doi:10.1016/B978-0-12-396481-6.00015-5

Bradyzoite Development

Laura J. Knoll, Tadakimi Tomita, Louis M. Weiss

Pathology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

14 Scopus citations

Abstract

Once the acute phase of Toxoplasma gondii infection resolves, the parasite remains latent as bradyzoite forms that persist within tissue cysts. The stress-induced conversion of tachyzoites to bradyzoites is a critical step in pathogenesis of toxoplasmosis, because latent bradyzoite forms can reactivate with waning immune function and are infectious to other hosts. Despite their biological importance, the biology of bradyzoites and the molecular mechanisms for developmental transition are not well understood. Bradyzoites express unique antigens and metabolic enzymes and are encased within a highly glycosylated cyst wall, This chapter reviews our progress in understanding unique structural components of bradyzoite cysts and the signalling processes that lead to T. gondii persistence.

Original language	English (US)
Title of host publication	Toxoplasma Gondii
Subtitle of host publication	The Model Apicomplexan - Perspectives and Methods: Second Edition
Publisher	Elsevier Ltd.
Pages	521-549
Number of pages	29
ISBN (Print)	9780123964816
DOIs	https://doi.org/10.1016/B978-0-12-396481-6.00015-5
State	Published - Sep 2013

Keywords

Bradyzoite
Cyclic AMP
Cyst
Differentiation
Glycosylation
Heat shock proteins
Latency
Parasitophorous vacuole
Stress

ASJC Scopus subject areas

General Immunology and Microbiology

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10.1016/B978-0-12-396481-6.00015-5

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title = "Bradyzoite Development",

abstract = "Once the acute phase of Toxoplasma gondii infection resolves, the parasite remains latent as bradyzoite forms that persist within tissue cysts. The stress-induced conversion of tachyzoites to bradyzoites is a critical step in pathogenesis of toxoplasmosis, because latent bradyzoite forms can reactivate with waning immune function and are infectious to other hosts. Despite their biological importance, the biology of bradyzoites and the molecular mechanisms for developmental transition are not well understood. Bradyzoites express unique antigens and metabolic enzymes and are encased within a highly glycosylated cyst wall, This chapter reviews our progress in understanding unique structural components of bradyzoite cysts and the signalling processes that lead to T. gondii persistence.",

keywords = "Bradyzoite, Cyclic AMP, Cyst, Differentiation, Glycosylation, Heat shock proteins, Latency, Parasitophorous vacuole, Stress",

author = "Knoll, {Laura J.} and Tadakimi Tomita and Weiss, {Louis M.}",

note = "Funding Information: This work was supported by the American Heart Association 0840059N (LJK) and NIH grants AI39454 and AI095094 (LMW), and T32-AI070117 (TT). We thank the members of our laboratories for their dedication and our colleagues in the Toxoplasma community for stimulating discussions and sharing unpublished data. ",

year = "2013",

month = sep,

doi = "10.1016/B978-0-12-396481-6.00015-5",

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T1 - Bradyzoite Development

AU - Knoll, Laura J.

AU - Tomita, Tadakimi

AU - Weiss, Louis M.

N1 - Funding Information: This work was supported by the American Heart Association 0840059N (LJK) and NIH grants AI39454 and AI095094 (LMW), and T32-AI070117 (TT). We thank the members of our laboratories for their dedication and our colleagues in the Toxoplasma community for stimulating discussions and sharing unpublished data.

PY - 2013/9

Y1 - 2013/9

N2 - Once the acute phase of Toxoplasma gondii infection resolves, the parasite remains latent as bradyzoite forms that persist within tissue cysts. The stress-induced conversion of tachyzoites to bradyzoites is a critical step in pathogenesis of toxoplasmosis, because latent bradyzoite forms can reactivate with waning immune function and are infectious to other hosts. Despite their biological importance, the biology of bradyzoites and the molecular mechanisms for developmental transition are not well understood. Bradyzoites express unique antigens and metabolic enzymes and are encased within a highly glycosylated cyst wall, This chapter reviews our progress in understanding unique structural components of bradyzoite cysts and the signalling processes that lead to T. gondii persistence.

AB - Once the acute phase of Toxoplasma gondii infection resolves, the parasite remains latent as bradyzoite forms that persist within tissue cysts. The stress-induced conversion of tachyzoites to bradyzoites is a critical step in pathogenesis of toxoplasmosis, because latent bradyzoite forms can reactivate with waning immune function and are infectious to other hosts. Despite their biological importance, the biology of bradyzoites and the molecular mechanisms for developmental transition are not well understood. Bradyzoites express unique antigens and metabolic enzymes and are encased within a highly glycosylated cyst wall, This chapter reviews our progress in understanding unique structural components of bradyzoite cysts and the signalling processes that lead to T. gondii persistence.

KW - Bradyzoite

KW - Cyclic AMP

KW - Cyst

KW - Differentiation

KW - Glycosylation

KW - Heat shock proteins

KW - Latency

KW - Parasitophorous vacuole

KW - Stress

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U2 - 10.1016/B978-0-12-396481-6.00015-5

DO - 10.1016/B978-0-12-396481-6.00015-5

M3 - Chapter

AN - SCOPUS:84904080263

SN - 9780123964816

SP - 521

EP - 549

BT - Toxoplasma Gondii

PB - Elsevier Ltd.

ER -

Bradyzoite Development

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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