Bradyzoite Development

Research output: Chapter in Book/Report/Conference proceedingChapter

10 Scopus citations

Abstract

Once the acute phase of Toxoplasma gondii infection resolves, the parasite remains latent as bradyzoite forms that persist within tissue cysts. The stress-induced conversion of tachyzoites to bradyzoites is a critical step in pathogenesis of toxoplasmosis, because latent bradyzoite forms can reactivate with waning immune function and are infectious to other hosts. Despite their biological importance, the biology of bradyzoites and the molecular mechanisms for developmental transition are not well understood. Bradyzoites express unique antigens and metabolic enzymes and are encased within a highly glycosylated cyst wall, This chapter reviews our progress in understanding unique structural components of bradyzoite cysts and the signalling processes that lead to T. gondii persistence.

Original languageEnglish (US)
Title of host publicationToxoplasma Gondii
Subtitle of host publicationThe Model Apicomplexan - Perspectives and Methods: Second Edition
PublisherElsevier Ltd.
Pages521-549
Number of pages29
ISBN (Print)9780123964816
DOIs
StatePublished - Sep 1 2013

Keywords

  • Bradyzoite
  • Cyclic AMP
  • Cyst
  • Differentiation
  • Glycosylation
  • Heat shock proteins
  • Latency
  • Parasitophorous vacuole
  • Stress

ASJC Scopus subject areas

  • Immunology and Microbiology(all)

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