Bortezomib-induced tumor lysis syndrome in a patient with HIV-negative plasmablastic lymphoma

Mark Lipstein, Owen O'Connor, Francesca Montanari, Luca Paoluzzi, Danielle Bongero, Govind Bhagat

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Plasmablastic lymphoma (PBL) is an aggressive lymphoma classified by the World Health Organization as a subtype of diffuse large B-cell lymphoma that shares many morphologic and immunophenotypic features with multiple myeloma. It is extremely rare in immunocompetent patients. Because of the small number of patients reported, this rare lymphoma remains a poorly characterized and understood entity with presently no standard recommendations regarding the optimal treatment. Herein, we report a dramatic clinical response coupled with tumor lysis syndrome to a bortezomib-based treatment in an HIV-negative patient with refractory plasmablastic lymphoma.

Original languageEnglish (US)
Pages (from-to)E43-E46
JournalClinical Lymphoma, Myeloma and Leukemia
Volume10
Issue number5
DOIs
StatePublished - Oct 1 2010
Externally publishedYes

Keywords

  • Diffuse large B-cell lymphoma
  • Non-Hodgkin lymphoma
  • R-CHOP

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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