Boron nitride nanotubes are noncytotoxic and can be functionalized for interaction with proteins and cells

Xing Chen; Peng Wu; Michael Rousseas; David Okawa; Zev Gartner; Alex Zettl; Carolyn R. Bertozzi

doi:10.1021/ja807334b

Boron nitride nanotubes are noncytotoxic and can be functionalized for interaction with proteins and cells

Xing Chen, Peng Wu, Michael Rousseas, David Okawa, Zev Gartner, Alex Zettl, Carolyn R. Bertozzi

Research output: Contribution to journal › Article › peer-review

504 Scopus citations

Abstract

We report the discovery that boron nitride nanotubes (BNNTs), isosteres of CNTs with unique physical properties, are inherently noncytotoxic. Furthermore, we developed a biomemetic coating strategy to interface BNNTs with proteins and cells. Finally, we showed that BNNTs can deliver DNA oligomers to the interior of cells with no apparent toxicity. This work suggests that BNNTs may be superior to CNTs for use as biological probes and in biomaterials.

Original language	English (US)
Pages (from-to)	890-891
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	131
Issue number	3
DOIs	https://doi.org/10.1021/ja807334b
State	Published - Jan 28 2009
Externally published	Yes

ASJC Scopus subject areas

Catalysis
General Chemistry
Biochemistry
Colloid and Surface Chemistry

Access to Document

10.1021/ja807334b

Cite this

@article{c6fb68ddc1ea48509d6fe6249f44fa6e,

title = "Boron nitride nanotubes are noncytotoxic and can be functionalized for interaction with proteins and cells",

abstract = "We report the discovery that boron nitride nanotubes (BNNTs), isosteres of CNTs with unique physical properties, are inherently noncytotoxic. Furthermore, we developed a biomemetic coating strategy to interface BNNTs with proteins and cells. Finally, we showed that BNNTs can deliver DNA oligomers to the interior of cells with no apparent toxicity. This work suggests that BNNTs may be superior to CNTs for use as biological probes and in biomaterials.",

author = "Xing Chen and Peng Wu and Michael Rousseas and David Okawa and Zev Gartner and Alex Zettl and Bertozzi, {Carolyn R.}",

year = "2009",

month = jan,

day = "28",

doi = "10.1021/ja807334b",

language = "English (US)",

volume = "131",

pages = "890--891",

journal = "Journal of the American Chemical Society",

issn = "0002-7863",

publisher = "American Chemical Society",

number = "3",

}

TY - JOUR

T1 - Boron nitride nanotubes are noncytotoxic and can be functionalized for interaction with proteins and cells

AU - Chen, Xing

AU - Wu, Peng

AU - Rousseas, Michael

AU - Okawa, David

AU - Gartner, Zev

AU - Zettl, Alex

AU - Bertozzi, Carolyn R.

PY - 2009/1/28

Y1 - 2009/1/28

N2 - We report the discovery that boron nitride nanotubes (BNNTs), isosteres of CNTs with unique physical properties, are inherently noncytotoxic. Furthermore, we developed a biomemetic coating strategy to interface BNNTs with proteins and cells. Finally, we showed that BNNTs can deliver DNA oligomers to the interior of cells with no apparent toxicity. This work suggests that BNNTs may be superior to CNTs for use as biological probes and in biomaterials.

AB - We report the discovery that boron nitride nanotubes (BNNTs), isosteres of CNTs with unique physical properties, are inherently noncytotoxic. Furthermore, we developed a biomemetic coating strategy to interface BNNTs with proteins and cells. Finally, we showed that BNNTs can deliver DNA oligomers to the interior of cells with no apparent toxicity. This work suggests that BNNTs may be superior to CNTs for use as biological probes and in biomaterials.

UR - http://www.scopus.com/inward/record.url?scp=61749094305&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=61749094305&partnerID=8YFLogxK

U2 - 10.1021/ja807334b

DO - 10.1021/ja807334b

M3 - Article

C2 - 19119844

AN - SCOPUS:61749094305

SN - 0002-7863

VL - 131

SP - 890

EP - 891

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 3

ER -

Boron nitride nanotubes are noncytotoxic and can be functionalized for interaction with proteins and cells

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this