Bone morphogenetic proteins promote astroglial lineage commitment by mammalian subventricular zone progenitor cells

Robert E. Gross, Mark F. Mehler, Peter C. Mabie, Ziying Zang, Linda Santschi, John A. Kessler

Research output: Contribution to journalArticle

531 Citations (Scopus)

Abstract

The epigenetic signals that regulate lineage development in the embryonic mammalian brain are poorly understood. Here we demonstrate that a specific subclass of the transforming growth factor β superfamily, the bone morphogenetic proteins (BMPs), cause the selective, dose-dependent elaboration of the astroglial lineage from murine embryonic subventricular zone (SVZ) multipotent progenitor cells. The astroglial inductive effect is characterized by enhanced morphological complexity and expression of glial fibrillary acidic protein, with concurrent suppression of neuronal and oligodendroglial cell fates. SVZ progenitor cells express transcripts for the appropriate BMP-specific type I and II receptor subunits and selective BMP ligands, suggesting the presence of paracrine or autocrine developmental signaling pathways (or both). These observations suggest that the BMPs have a selective role in determining the cell fate of SVZ multipotent progenitor cells or their more developmentally restricted progeny.

Original languageEnglish (US)
Pages (from-to)595-606
Number of pages12
JournalNeuron
Volume17
Issue number4
DOIs
StatePublished - Oct 1996

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Bone Morphogenetic Proteins
Lateral Ventricles
Stem Cells
Type I Bone Morphogenetic Protein Receptors
Type II Bone Morphogenetic Protein Receptors
Autocrine Communication
Glial Fibrillary Acidic Protein
Transforming Growth Factors
Epigenomics
Embryonic Development
Ligands
Brain

ASJC Scopus subject areas

  • Neuroscience(all)

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Bone morphogenetic proteins promote astroglial lineage commitment by mammalian subventricular zone progenitor cells. / Gross, Robert E.; Mehler, Mark F.; Mabie, Peter C.; Zang, Ziying; Santschi, Linda; Kessler, John A.

In: Neuron, Vol. 17, No. 4, 10.1996, p. 595-606.

Research output: Contribution to journalArticle

Gross, Robert E. ; Mehler, Mark F. ; Mabie, Peter C. ; Zang, Ziying ; Santschi, Linda ; Kessler, John A. / Bone morphogenetic proteins promote astroglial lineage commitment by mammalian subventricular zone progenitor cells. In: Neuron. 1996 ; Vol. 17, No. 4. pp. 595-606.
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