Bone morphogenetic proteins in the nervous system

Mark F. Mehler, Peter C. Mabie, Damin Zhang, John A. Kessler

Research output: Contribution to journalArticle

333 Citations (Scopus)

Abstract

Bone morphogenetic proteins (BMPs) are a rapidly expanding subclass of the transforming growth factor superfamily. BMP ligands and receptor subunits are present throughout neural development within discrete regions of the embryonic brain and within neural crest-derived pre- and postmigratory zones. BMPs initially inhibit the formation of neuroectoderm during gastrulation while, within the neural tube, they act as gradient morphogens to promote the differentiation of dorsal cell types and intermediate cell types throughout co-operative signaling. In the peripheral nervous system, BMPs act as instructive signals for neuronal lineage commitment and promote graded stages of neuronal differentiation. By contrast, within the CNS, these same factors promote astroglial lineage elaboration from embryonic subventricular zone progenitor cells, with concurrent suppression of the neuronal or oligodendroglial lineages, or both. In addition, BMPs act on more lineage- restricted embryonic CNS progenitor cells to promote regional neuronal survival and cellular differentiation. Furthermore, these versatile cytokines induce selective apoptosis of discrete rhombencephalic neural crest- associated cellular populations. These observations suggest that the BMPs exhibit a broad range of cellular and context-specific effects during multiple stages of neural development.

Original languageEnglish (US)
Pages (from-to)309-317
Number of pages9
JournalTrends in Neurosciences
Volume20
Issue number7
DOIs
StatePublished - Jul 1 1997

Fingerprint

Bone Morphogenetic Proteins
Nervous System
Neural Crest
Stem Cells
Bone Morphogenetic Protein Receptors
Neural Plate
Gastrulation
Neural Tube
Lateral Ventricles
Peripheral Nervous System
Transforming Growth Factors
Cell Differentiation
Apoptosis
Cytokines
Ligands
Brain
Population

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Bone morphogenetic proteins in the nervous system. / Mehler, Mark F.; Mabie, Peter C.; Zhang, Damin; Kessler, John A.

In: Trends in Neurosciences, Vol. 20, No. 7, 01.07.1997, p. 309-317.

Research output: Contribution to journalArticle

Mehler, Mark F. ; Mabie, Peter C. ; Zhang, Damin ; Kessler, John A. / Bone morphogenetic proteins in the nervous system. In: Trends in Neurosciences. 1997 ; Vol. 20, No. 7. pp. 309-317.
@article{6e3e7bc64a5c43cb9529afedfd2fb51b,
title = "Bone morphogenetic proteins in the nervous system",
abstract = "Bone morphogenetic proteins (BMPs) are a rapidly expanding subclass of the transforming growth factor superfamily. BMP ligands and receptor subunits are present throughout neural development within discrete regions of the embryonic brain and within neural crest-derived pre- and postmigratory zones. BMPs initially inhibit the formation of neuroectoderm during gastrulation while, within the neural tube, they act as gradient morphogens to promote the differentiation of dorsal cell types and intermediate cell types throughout co-operative signaling. In the peripheral nervous system, BMPs act as instructive signals for neuronal lineage commitment and promote graded stages of neuronal differentiation. By contrast, within the CNS, these same factors promote astroglial lineage elaboration from embryonic subventricular zone progenitor cells, with concurrent suppression of the neuronal or oligodendroglial lineages, or both. In addition, BMPs act on more lineage- restricted embryonic CNS progenitor cells to promote regional neuronal survival and cellular differentiation. Furthermore, these versatile cytokines induce selective apoptosis of discrete rhombencephalic neural crest- associated cellular populations. These observations suggest that the BMPs exhibit a broad range of cellular and context-specific effects during multiple stages of neural development.",
author = "Mehler, {Mark F.} and Mabie, {Peter C.} and Damin Zhang and Kessler, {John A.}",
year = "1997",
month = "7",
day = "1",
doi = "10.1016/S0166-2236(96)01046-6",
language = "English (US)",
volume = "20",
pages = "309--317",
journal = "Trends in Neurosciences",
issn = "0378-5912",
publisher = "Elsevier Limited",
number = "7",

}

TY - JOUR

T1 - Bone morphogenetic proteins in the nervous system

AU - Mehler, Mark F.

AU - Mabie, Peter C.

AU - Zhang, Damin

AU - Kessler, John A.

PY - 1997/7/1

Y1 - 1997/7/1

N2 - Bone morphogenetic proteins (BMPs) are a rapidly expanding subclass of the transforming growth factor superfamily. BMP ligands and receptor subunits are present throughout neural development within discrete regions of the embryonic brain and within neural crest-derived pre- and postmigratory zones. BMPs initially inhibit the formation of neuroectoderm during gastrulation while, within the neural tube, they act as gradient morphogens to promote the differentiation of dorsal cell types and intermediate cell types throughout co-operative signaling. In the peripheral nervous system, BMPs act as instructive signals for neuronal lineage commitment and promote graded stages of neuronal differentiation. By contrast, within the CNS, these same factors promote astroglial lineage elaboration from embryonic subventricular zone progenitor cells, with concurrent suppression of the neuronal or oligodendroglial lineages, or both. In addition, BMPs act on more lineage- restricted embryonic CNS progenitor cells to promote regional neuronal survival and cellular differentiation. Furthermore, these versatile cytokines induce selective apoptosis of discrete rhombencephalic neural crest- associated cellular populations. These observations suggest that the BMPs exhibit a broad range of cellular and context-specific effects during multiple stages of neural development.

AB - Bone morphogenetic proteins (BMPs) are a rapidly expanding subclass of the transforming growth factor superfamily. BMP ligands and receptor subunits are present throughout neural development within discrete regions of the embryonic brain and within neural crest-derived pre- and postmigratory zones. BMPs initially inhibit the formation of neuroectoderm during gastrulation while, within the neural tube, they act as gradient morphogens to promote the differentiation of dorsal cell types and intermediate cell types throughout co-operative signaling. In the peripheral nervous system, BMPs act as instructive signals for neuronal lineage commitment and promote graded stages of neuronal differentiation. By contrast, within the CNS, these same factors promote astroglial lineage elaboration from embryonic subventricular zone progenitor cells, with concurrent suppression of the neuronal or oligodendroglial lineages, or both. In addition, BMPs act on more lineage- restricted embryonic CNS progenitor cells to promote regional neuronal survival and cellular differentiation. Furthermore, these versatile cytokines induce selective apoptosis of discrete rhombencephalic neural crest- associated cellular populations. These observations suggest that the BMPs exhibit a broad range of cellular and context-specific effects during multiple stages of neural development.

UR - http://www.scopus.com/inward/record.url?scp=0030792319&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030792319&partnerID=8YFLogxK

U2 - 10.1016/S0166-2236(96)01046-6

DO - 10.1016/S0166-2236(96)01046-6

M3 - Article

C2 - 9223224

AN - SCOPUS:0030792319

VL - 20

SP - 309

EP - 317

JO - Trends in Neurosciences

JF - Trends in Neurosciences

SN - 0378-5912

IS - 7

ER -