Bone, inflammation, and inflammatory bowel disease

Manasi Agrawal, Shitij Arora, Jianjun Li, Rabin Rahmani, Li Sun, Adam F. Steinlauf, Jeffrey I. Mechanick, Mone Zaidi

Research output: Contribution to journalArticlepeer-review

57 Scopus citations


Osteoporosis is a leading cause of morbidity in patients with inflammatory bowel disease (IBD). Bone loss is an early systemic process and occurs even before clinical disease manifests. Bone disease is attributed to vitamin D deficiency, steroid use, and/or systemic inflammation. In this review, we discuss the molecular pathways of bone loss mediated by inflammatory cytokines and other mediators. Further research will hopefully clarify the mechanisms of inflammation-induced bone loss in IBD and guide effective treatment modalities.

Original languageEnglish (US)
Pages (from-to)251-257
Number of pages7
JournalCurrent Osteoporosis Reports
Issue number4
StatePublished - Dec 2011
Externally publishedYes


  • Bone
  • Bone loss
  • Cytokines
  • Inflammation
  • Inflammatory bowel disease
  • Osteoblast
  • Osteoclast

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism


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