Bone, inflammation, and inflammatory bowel disease

Manasi Agrawal, Shitij Arora, Jianjun Li, Rabin Rahmani, Li Sun, Adam F. Steinlauf, Jeffrey I. Mechanick, Mone Zaidi

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Osteoporosis is a leading cause of morbidity in patients with inflammatory bowel disease (IBD). Bone loss is an early systemic process and occurs even before clinical disease manifests. Bone disease is attributed to vitamin D deficiency, steroid use, and/or systemic inflammation. In this review, we discuss the molecular pathways of bone loss mediated by inflammatory cytokines and other mediators. Further research will hopefully clarify the mechanisms of inflammation-induced bone loss in IBD and guide effective treatment modalities.

Original languageEnglish (US)
Pages (from-to)251-257
Number of pages7
JournalCurrent Osteoporosis Reports
Volume9
Issue number4
DOIs
StatePublished - Dec 2011
Externally publishedYes

Fingerprint

Osteitis
Inflammatory Bowel Diseases
Bone and Bones
Vitamin D Deficiency
Bone Diseases
Osteoporosis
Steroids
Cytokines
Inflammation
Morbidity
Research
Therapeutics

Keywords

  • Bone
  • Bone loss
  • Cytokines
  • Inflammation
  • Inflammatory bowel disease
  • Osteoblast
  • Osteoclast

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

Cite this

Agrawal, M., Arora, S., Li, J., Rahmani, R., Sun, L., Steinlauf, A. F., ... Zaidi, M. (2011). Bone, inflammation, and inflammatory bowel disease. Current Osteoporosis Reports, 9(4), 251-257. https://doi.org/10.1007/s11914-011-0077-9

Bone, inflammation, and inflammatory bowel disease. / Agrawal, Manasi; Arora, Shitij; Li, Jianjun; Rahmani, Rabin; Sun, Li; Steinlauf, Adam F.; Mechanick, Jeffrey I.; Zaidi, Mone.

In: Current Osteoporosis Reports, Vol. 9, No. 4, 12.2011, p. 251-257.

Research output: Contribution to journalArticle

Agrawal, M, Arora, S, Li, J, Rahmani, R, Sun, L, Steinlauf, AF, Mechanick, JI & Zaidi, M 2011, 'Bone, inflammation, and inflammatory bowel disease', Current Osteoporosis Reports, vol. 9, no. 4, pp. 251-257. https://doi.org/10.1007/s11914-011-0077-9
Agrawal, Manasi ; Arora, Shitij ; Li, Jianjun ; Rahmani, Rabin ; Sun, Li ; Steinlauf, Adam F. ; Mechanick, Jeffrey I. ; Zaidi, Mone. / Bone, inflammation, and inflammatory bowel disease. In: Current Osteoporosis Reports. 2011 ; Vol. 9, No. 4. pp. 251-257.
@article{3b9f20e1f6f048c0b1dfea493d811c6d,
title = "Bone, inflammation, and inflammatory bowel disease",
abstract = "Osteoporosis is a leading cause of morbidity in patients with inflammatory bowel disease (IBD). Bone loss is an early systemic process and occurs even before clinical disease manifests. Bone disease is attributed to vitamin D deficiency, steroid use, and/or systemic inflammation. In this review, we discuss the molecular pathways of bone loss mediated by inflammatory cytokines and other mediators. Further research will hopefully clarify the mechanisms of inflammation-induced bone loss in IBD and guide effective treatment modalities.",
keywords = "Bone, Bone loss, Cytokines, Inflammation, Inflammatory bowel disease, Osteoblast, Osteoclast",
author = "Manasi Agrawal and Shitij Arora and Jianjun Li and Rabin Rahmani and Li Sun and Steinlauf, {Adam F.} and Mechanick, {Jeffrey I.} and Mone Zaidi",
year = "2011",
month = "12",
doi = "10.1007/s11914-011-0077-9",
language = "English (US)",
volume = "9",
pages = "251--257",
journal = "Current Osteoporosis Reports",
issn = "1544-1873",
publisher = "Current Science, Inc.",
number = "4",

}

TY - JOUR

T1 - Bone, inflammation, and inflammatory bowel disease

AU - Agrawal, Manasi

AU - Arora, Shitij

AU - Li, Jianjun

AU - Rahmani, Rabin

AU - Sun, Li

AU - Steinlauf, Adam F.

AU - Mechanick, Jeffrey I.

AU - Zaidi, Mone

PY - 2011/12

Y1 - 2011/12

N2 - Osteoporosis is a leading cause of morbidity in patients with inflammatory bowel disease (IBD). Bone loss is an early systemic process and occurs even before clinical disease manifests. Bone disease is attributed to vitamin D deficiency, steroid use, and/or systemic inflammation. In this review, we discuss the molecular pathways of bone loss mediated by inflammatory cytokines and other mediators. Further research will hopefully clarify the mechanisms of inflammation-induced bone loss in IBD and guide effective treatment modalities.

AB - Osteoporosis is a leading cause of morbidity in patients with inflammatory bowel disease (IBD). Bone loss is an early systemic process and occurs even before clinical disease manifests. Bone disease is attributed to vitamin D deficiency, steroid use, and/or systemic inflammation. In this review, we discuss the molecular pathways of bone loss mediated by inflammatory cytokines and other mediators. Further research will hopefully clarify the mechanisms of inflammation-induced bone loss in IBD and guide effective treatment modalities.

KW - Bone

KW - Bone loss

KW - Cytokines

KW - Inflammation

KW - Inflammatory bowel disease

KW - Osteoblast

KW - Osteoclast

UR - http://www.scopus.com/inward/record.url?scp=81255142138&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=81255142138&partnerID=8YFLogxK

U2 - 10.1007/s11914-011-0077-9

DO - 10.1007/s11914-011-0077-9

M3 - Article

C2 - 21935582

AN - SCOPUS:81255142138

VL - 9

SP - 251

EP - 257

JO - Current Osteoporosis Reports

JF - Current Osteoporosis Reports

SN - 1544-1873

IS - 4

ER -