Body size, physical activity, and risk of triple-negative and estrogen receptor-positive breast cancer

Amanda I. Phipps, Rowan T. Chlebowski, Ross Prentice, Anne McTiernan, Marcia L. Stefanick, Jean Wactawski-Wende, Lewis H. Kuller, Lucile L. Adams-Campbell, Dorothy Lane, Mara Vitolins, Geoffrey C. Kabat, Thomas E. Rohan, Christopher I. Li

Research output: Contribution to journalArticle

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Abstract

Background: Triple-negative breast cancer, characterized by a lack of hormone receptor and HER2 expression, is associated with a particularly poor prognosis. Focusing on potentially modifiable breast cancer risk factors, we examined the relationship between body size, physical activity, and triple-negative disease risk. Methods: Using data from 155,723 women enrolled in the Women's Health Initiative (median follow-up, 7.9 years), we assessed associations between baseline body mass index (BMI), BMI in earlier adulthood, waist and hip circumference, waist-hip ratio, recreational physical activity, and risk of triple-negative (n = 307) and estrogen receptor-positive (ER +, n = 2,610) breast cancers. Results: Women in the highest versus lowest BMI quartile had 1.35-fold (95% CI, 0.92-1.99) and 1.39-fold (95% CI, 1.22-1.58) increased risks of triple-negative and ER+ breast cancers, respectively. Waist and hip circumferences were positively associated with risk of ER+ breast cancer (Ptrend = 0.01 for both measures) but were not associated with triple-negative breast cancer. Compared with women who reported no recreational physical activity, women in the highest activity tertile had similarly lower risks of triple-negative and ER+ breast cancers (HR = 0.77; 95% CI, 0.51-1.13; and HR = 0.85; 95% CI, 0.74-0.98, respectively). Conclusions: Despite biological and clinical differences, triple-negative and ER+ breast cancers are similarly associated with BMI and recreational physical activity in postmenopausal women. The biological mechanisms underlying these similarities are uncertain and these modest associations require further investigation. Impact: If confirmed, these results suggest potential ways postmenopausal women might modify their risk of both ER+ and triple-negative breast cancers.

Original languageEnglish (US)
Pages (from-to)454-463
Number of pages10
JournalCancer Epidemiology Biomarkers and Prevention
Volume20
Issue number3
DOIs
StatePublished - Mar 2011

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Triple Negative Breast Neoplasms
Body Size
Estrogen Receptors
Exercise
Breast Neoplasms
Body Mass Index
Waist Circumference
Hip
Waist-Hip Ratio
Women's Health
Hormones

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

Cite this

Phipps, A. I., Chlebowski, R. T., Prentice, R., McTiernan, A., Stefanick, M. L., Wactawski-Wende, J., ... Li, C. I. (2011). Body size, physical activity, and risk of triple-negative and estrogen receptor-positive breast cancer. Cancer Epidemiology Biomarkers and Prevention, 20(3), 454-463. https://doi.org/10.1158/1055-9965.EPI-10-0974

Body size, physical activity, and risk of triple-negative and estrogen receptor-positive breast cancer. / Phipps, Amanda I.; Chlebowski, Rowan T.; Prentice, Ross; McTiernan, Anne; Stefanick, Marcia L.; Wactawski-Wende, Jean; Kuller, Lewis H.; Adams-Campbell, Lucile L.; Lane, Dorothy; Vitolins, Mara; Kabat, Geoffrey C.; Rohan, Thomas E.; Li, Christopher I.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 20, No. 3, 03.2011, p. 454-463.

Research output: Contribution to journalArticle

Phipps, AI, Chlebowski, RT, Prentice, R, McTiernan, A, Stefanick, ML, Wactawski-Wende, J, Kuller, LH, Adams-Campbell, LL, Lane, D, Vitolins, M, Kabat, GC, Rohan, TE & Li, CI 2011, 'Body size, physical activity, and risk of triple-negative and estrogen receptor-positive breast cancer', Cancer Epidemiology Biomarkers and Prevention, vol. 20, no. 3, pp. 454-463. https://doi.org/10.1158/1055-9965.EPI-10-0974
Phipps, Amanda I. ; Chlebowski, Rowan T. ; Prentice, Ross ; McTiernan, Anne ; Stefanick, Marcia L. ; Wactawski-Wende, Jean ; Kuller, Lewis H. ; Adams-Campbell, Lucile L. ; Lane, Dorothy ; Vitolins, Mara ; Kabat, Geoffrey C. ; Rohan, Thomas E. ; Li, Christopher I. / Body size, physical activity, and risk of triple-negative and estrogen receptor-positive breast cancer. In: Cancer Epidemiology Biomarkers and Prevention. 2011 ; Vol. 20, No. 3. pp. 454-463.
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abstract = "Background: Triple-negative breast cancer, characterized by a lack of hormone receptor and HER2 expression, is associated with a particularly poor prognosis. Focusing on potentially modifiable breast cancer risk factors, we examined the relationship between body size, physical activity, and triple-negative disease risk. Methods: Using data from 155,723 women enrolled in the Women's Health Initiative (median follow-up, 7.9 years), we assessed associations between baseline body mass index (BMI), BMI in earlier adulthood, waist and hip circumference, waist-hip ratio, recreational physical activity, and risk of triple-negative (n = 307) and estrogen receptor-positive (ER +, n = 2,610) breast cancers. Results: Women in the highest versus lowest BMI quartile had 1.35-fold (95{\%} CI, 0.92-1.99) and 1.39-fold (95{\%} CI, 1.22-1.58) increased risks of triple-negative and ER+ breast cancers, respectively. Waist and hip circumferences were positively associated with risk of ER+ breast cancer (Ptrend = 0.01 for both measures) but were not associated with triple-negative breast cancer. Compared with women who reported no recreational physical activity, women in the highest activity tertile had similarly lower risks of triple-negative and ER+ breast cancers (HR = 0.77; 95{\%} CI, 0.51-1.13; and HR = 0.85; 95{\%} CI, 0.74-0.98, respectively). Conclusions: Despite biological and clinical differences, triple-negative and ER+ breast cancers are similarly associated with BMI and recreational physical activity in postmenopausal women. The biological mechanisms underlying these similarities are uncertain and these modest associations require further investigation. Impact: If confirmed, these results suggest potential ways postmenopausal women might modify their risk of both ER+ and triple-negative breast cancers.",
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