TY - JOUR
T1 - Body size indicators and risk of gallbladder cancer
T2 - Pooled analysis of individual-level data from 19 prospective cohort studies
AU - Campbell, Peter T.
AU - Newton, Christina C.
AU - Kitahara, Cari M.
AU - Patel, Alpa V.
AU - Hartge, Patricia
AU - Koshiol, Jill
AU - McGlynn, Katherine A.
AU - Adami, Hans Olov
AU - De Gonzalez, Amy Berrington
AU - Freeman, Laura E.Beane
AU - Bernstein, Leslie
AU - Buring, Julie E.
AU - Freedman, Neal D.
AU - Gao, Yu Tang
AU - Giles, Graham G.
AU - Gunter, Marc J.
AU - Jenab, Mazda
AU - Liao, Linda M.
AU - Milne, Roger L.
AU - Robien, Kim
AU - Sandler, Dale P.
AU - Schairer, Catherine
AU - Sesso, Howard D.
AU - Shu, Xiao Ou
AU - Weiderpass, Elisabete
AU - Wolk, Alicja
AU - Xiang, Yong Bing
AU - Zeleniuch-Jacquotte, Anne
AU - Zheng, Wei
AU - Gapstur, Susan M.
N1 - Publisher Copyright:
© 2017 American Association for Cancer Research.
PY - 2017/4
Y1 - 2017/4
N2 - Background: There are few established risk factors for gallbladder cancer beyond gallstones. Recent studies suggest a higher risk with high body mass index (BMI), an indicator of general heaviness, but evidence from other body size measures is lacking. Methods: Associations of adult BMI, young adult BMI, height, adult weight gain, waist circumference (WC), waist-height ratio (WHtR), hip circumference (HC), and waist-hip ratio (WHR) with gallbladder cancer risk were evaluated. Individual-level data from 1,878,801 participants in 19 prospective cohort studies (14 studies had circumference measures) were harmonized and included in this analysis. Multivariable Cox proportional hazards regression estimated hazard ratios (HR) and 95% confidence intervals (CI). Results: After enrollment, 567 gallbladder cancer cases were identified during 20.1 million person-years of observation, including 361 cases with WC measures. Higher adult BMI (per 5 kg/m2, HR: 1.24; 95% CI, 1.13-1.35), young adult BMI (per 5 kg/m2, HR: 1.12; 95% CI, 1.00-1.26), adult weight gain (per 5 kg, HR: 1.07; 95% CI, 1.02-1.12), height (per 5 cm, HR: 1.10; 95% CI, 1.03-1.17),WC(per 5 cm, HR: 1.09; 95% CI, 1.02-1.17), WHtR (per 0.1 unit, HR: 1.24; 95% CI, 1.00-1.54), and HC (per 5 cm, HR: 1.13; 95% CI, 1.04-1.22), but not WHR (per 0.1 unit, HR: 1.03; 95% CI, 0.87-1.22), were associated with higher risks of gallbladder cancer, and results did not differ meaningfully by sex or other demographic/lifestyle factors. Conclusions: These findings indicate that measures of overall and central excess body weight are associated with higher gallbladder cancer risks. Impact: Excess body weight is an important, and potentially preventable, gallbladder cancer risk factor.
AB - Background: There are few established risk factors for gallbladder cancer beyond gallstones. Recent studies suggest a higher risk with high body mass index (BMI), an indicator of general heaviness, but evidence from other body size measures is lacking. Methods: Associations of adult BMI, young adult BMI, height, adult weight gain, waist circumference (WC), waist-height ratio (WHtR), hip circumference (HC), and waist-hip ratio (WHR) with gallbladder cancer risk were evaluated. Individual-level data from 1,878,801 participants in 19 prospective cohort studies (14 studies had circumference measures) were harmonized and included in this analysis. Multivariable Cox proportional hazards regression estimated hazard ratios (HR) and 95% confidence intervals (CI). Results: After enrollment, 567 gallbladder cancer cases were identified during 20.1 million person-years of observation, including 361 cases with WC measures. Higher adult BMI (per 5 kg/m2, HR: 1.24; 95% CI, 1.13-1.35), young adult BMI (per 5 kg/m2, HR: 1.12; 95% CI, 1.00-1.26), adult weight gain (per 5 kg, HR: 1.07; 95% CI, 1.02-1.12), height (per 5 cm, HR: 1.10; 95% CI, 1.03-1.17),WC(per 5 cm, HR: 1.09; 95% CI, 1.02-1.17), WHtR (per 0.1 unit, HR: 1.24; 95% CI, 1.00-1.54), and HC (per 5 cm, HR: 1.13; 95% CI, 1.04-1.22), but not WHR (per 0.1 unit, HR: 1.03; 95% CI, 0.87-1.22), were associated with higher risks of gallbladder cancer, and results did not differ meaningfully by sex or other demographic/lifestyle factors. Conclusions: These findings indicate that measures of overall and central excess body weight are associated with higher gallbladder cancer risks. Impact: Excess body weight is an important, and potentially preventable, gallbladder cancer risk factor.
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U2 - 10.1158/1055-9965.EPI-16-0796
DO - 10.1158/1055-9965.EPI-16-0796
M3 - Article
C2 - 28314823
AN - SCOPUS:85016959682
SN - 1055-9965
VL - 26
SP - 597
EP - 606
JO - Cancer Epidemiology Biomarkers and Prevention
JF - Cancer Epidemiology Biomarkers and Prevention
IS - 4
ER -
