Body shape, adiposity index, and mortality in postmenopausal women: Findings from the Women's Health Initiative

Cynthia A. Thomson, David O. Garcia, Betsy C. Wertheim, Melanie D. Hingle, Jennifer W. Bea, Oleg Zaslavsky, Graciela Caire-Juvera, Thomas E. Rohan, Mara Z. Vitolins, Patricia A. Thompson, Cora E. Lewis

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13 Scopus citations

Abstract

Objective Studies evaluating the relationship between body mass index (BMI) and mortality demonstrate a U-shaped association. To expand, this study evaluated the relationship between adiposity indices, a body shape index (ABSI) and body adiposity index (BAI), and mortality in 77,505 postmenopausal women. Methods A prospective cohort analysis was conducted in the Women's Health Initiative to ascertain the independent relationships between adiposity indices and mortality in order to inform on the clinical usefulness of alternate measures of mortality risk. ABSI (waist circumference (cm)/[BMI2/3 × height (cm)1/2]), BAI (hip circumference (cm)/[height (m)1.5] - 18), weight, BMI, and waist circumference (WC) were evaluated in relation to mortality risk using adjusted Cox proportional hazards regression models. Results ABSI showed a linear association with mortality (HR, 1.37; 95% CI, 1.28-1.47 for quintile 5 vs. 1) while BMI and BAI had U-shaped relationships with HR of 1.30; 95% CI, 1.20-1.40 for obesity II/III BMI and 1.06, 95% CI, 0.99-1.13 for BAI. Higher WC (HR, 1.21; 95% CI, 1.13-1.29 for quintile 5 vs. 1) showed relationships similar to BMI. Conclusions ABSI appears to be a clinically useful measure for estimating mortality risk, perhaps more so than BAI and BMI in postmenopausal women.

Original languageEnglish (US)
Pages (from-to)1061-1069
Number of pages9
JournalObesity
Volume24
Issue number5
DOIs
Publication statusPublished - May 1 2016

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ASJC Scopus subject areas

  • Endocrinology
  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Thomson, C. A., Garcia, D. O., Wertheim, B. C., Hingle, M. D., Bea, J. W., Zaslavsky, O., ... Lewis, C. E. (2016). Body shape, adiposity index, and mortality in postmenopausal women: Findings from the Women's Health Initiative. Obesity, 24(5), 1061-1069. https://doi.org/10.1002/oby.21461