Body mass index and lung cancer risk in women

Geoffrey C. Kabat, Anthony B. Miller, Thomas E. Rohan

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

BACKGROUND: Studies have suggested that leanness in adulthood may be a risk factor for lung cancer; however, there is justifiable concern that the observed association may be due to residual confounding by smoking, preclinical weight loss, competing causes of death, or some combination of these. METHODS: To examine this association we used data from the Canadian National Breast Screening Study, which included 89,835 women ages 40-59 years at recruitment between 1980 and 1985. During a mean of 16 years of follow-up, we observed 750 incident lung cancer cases. We used Cox proportional hazards models to estimate hazard ratios and 95% confidence intervals for the association between body mass index (BMI) and lung cancer. RESULTS: After adjustment for pack-years of smoking and other covariates, there was some evidence for inverse associations in current smokers (hazard ratio for highest BMI quintile relative to the lowest = 0.63; 95% confidence interval = 0.48-0.83) and in former smokers (0.69; 0.39-1.23), whereas in never-smokers, BMI was positively associated with lung cancer (2.19; 1.00-4.80). The results for current and former smokers were not altered by exclusion of cases diagnosed within the first 5 years of follow-up; however, in never-smokers the strength of the association was reduced. CONCLUSIONS: The present study contributes to the aggregate evidence suggesting that there may be an inverse association between BMI and lung cancer among smokers. However, the contrasting pattern of associations between BMI and lung cancer seen in ever-smokers and never-smokers in this study requires explanation.

Original languageEnglish (US)
Pages (from-to)607-612
Number of pages6
JournalEpidemiology
Volume18
Issue number5
DOIs
StatePublished - Sep 2007

Fingerprint

Lung Neoplasms
Body Mass Index
Smoking
Confidence Intervals
Thinness
Proportional Hazards Models
Weight Loss
Cause of Death
Breast

ASJC Scopus subject areas

  • Epidemiology

Cite this

Body mass index and lung cancer risk in women. / Kabat, Geoffrey C.; Miller, Anthony B.; Rohan, Thomas E.

In: Epidemiology, Vol. 18, No. 5, 09.2007, p. 607-612.

Research output: Contribution to journalArticle

Kabat, Geoffrey C. ; Miller, Anthony B. ; Rohan, Thomas E. / Body mass index and lung cancer risk in women. In: Epidemiology. 2007 ; Vol. 18, No. 5. pp. 607-612.
@article{42904dce93164e9ab9f1991eedfe4278,
title = "Body mass index and lung cancer risk in women",
abstract = "BACKGROUND: Studies have suggested that leanness in adulthood may be a risk factor for lung cancer; however, there is justifiable concern that the observed association may be due to residual confounding by smoking, preclinical weight loss, competing causes of death, or some combination of these. METHODS: To examine this association we used data from the Canadian National Breast Screening Study, which included 89,835 women ages 40-59 years at recruitment between 1980 and 1985. During a mean of 16 years of follow-up, we observed 750 incident lung cancer cases. We used Cox proportional hazards models to estimate hazard ratios and 95{\%} confidence intervals for the association between body mass index (BMI) and lung cancer. RESULTS: After adjustment for pack-years of smoking and other covariates, there was some evidence for inverse associations in current smokers (hazard ratio for highest BMI quintile relative to the lowest = 0.63; 95{\%} confidence interval = 0.48-0.83) and in former smokers (0.69; 0.39-1.23), whereas in never-smokers, BMI was positively associated with lung cancer (2.19; 1.00-4.80). The results for current and former smokers were not altered by exclusion of cases diagnosed within the first 5 years of follow-up; however, in never-smokers the strength of the association was reduced. CONCLUSIONS: The present study contributes to the aggregate evidence suggesting that there may be an inverse association between BMI and lung cancer among smokers. However, the contrasting pattern of associations between BMI and lung cancer seen in ever-smokers and never-smokers in this study requires explanation.",
author = "Kabat, {Geoffrey C.} and Miller, {Anthony B.} and Rohan, {Thomas E.}",
year = "2007",
month = "9",
doi = "10.1097/EDE.0b013e31812713d1",
language = "English (US)",
volume = "18",
pages = "607--612",
journal = "Epidemiology",
issn = "1044-3983",
publisher = "Lippincott Williams and Wilkins",
number = "5",

}

TY - JOUR

T1 - Body mass index and lung cancer risk in women

AU - Kabat, Geoffrey C.

AU - Miller, Anthony B.

AU - Rohan, Thomas E.

PY - 2007/9

Y1 - 2007/9

N2 - BACKGROUND: Studies have suggested that leanness in adulthood may be a risk factor for lung cancer; however, there is justifiable concern that the observed association may be due to residual confounding by smoking, preclinical weight loss, competing causes of death, or some combination of these. METHODS: To examine this association we used data from the Canadian National Breast Screening Study, which included 89,835 women ages 40-59 years at recruitment between 1980 and 1985. During a mean of 16 years of follow-up, we observed 750 incident lung cancer cases. We used Cox proportional hazards models to estimate hazard ratios and 95% confidence intervals for the association between body mass index (BMI) and lung cancer. RESULTS: After adjustment for pack-years of smoking and other covariates, there was some evidence for inverse associations in current smokers (hazard ratio for highest BMI quintile relative to the lowest = 0.63; 95% confidence interval = 0.48-0.83) and in former smokers (0.69; 0.39-1.23), whereas in never-smokers, BMI was positively associated with lung cancer (2.19; 1.00-4.80). The results for current and former smokers were not altered by exclusion of cases diagnosed within the first 5 years of follow-up; however, in never-smokers the strength of the association was reduced. CONCLUSIONS: The present study contributes to the aggregate evidence suggesting that there may be an inverse association between BMI and lung cancer among smokers. However, the contrasting pattern of associations between BMI and lung cancer seen in ever-smokers and never-smokers in this study requires explanation.

AB - BACKGROUND: Studies have suggested that leanness in adulthood may be a risk factor for lung cancer; however, there is justifiable concern that the observed association may be due to residual confounding by smoking, preclinical weight loss, competing causes of death, or some combination of these. METHODS: To examine this association we used data from the Canadian National Breast Screening Study, which included 89,835 women ages 40-59 years at recruitment between 1980 and 1985. During a mean of 16 years of follow-up, we observed 750 incident lung cancer cases. We used Cox proportional hazards models to estimate hazard ratios and 95% confidence intervals for the association between body mass index (BMI) and lung cancer. RESULTS: After adjustment for pack-years of smoking and other covariates, there was some evidence for inverse associations in current smokers (hazard ratio for highest BMI quintile relative to the lowest = 0.63; 95% confidence interval = 0.48-0.83) and in former smokers (0.69; 0.39-1.23), whereas in never-smokers, BMI was positively associated with lung cancer (2.19; 1.00-4.80). The results for current and former smokers were not altered by exclusion of cases diagnosed within the first 5 years of follow-up; however, in never-smokers the strength of the association was reduced. CONCLUSIONS: The present study contributes to the aggregate evidence suggesting that there may be an inverse association between BMI and lung cancer among smokers. However, the contrasting pattern of associations between BMI and lung cancer seen in ever-smokers and never-smokers in this study requires explanation.

UR - http://www.scopus.com/inward/record.url?scp=34547863833&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34547863833&partnerID=8YFLogxK

U2 - 10.1097/EDE.0b013e31812713d1

DO - 10.1097/EDE.0b013e31812713d1

M3 - Article

VL - 18

SP - 607

EP - 612

JO - Epidemiology

JF - Epidemiology

SN - 1044-3983

IS - 5

ER -