Blood type predicts live birth in the infertile population

Michelle Goldsammler, Sangita K. Jindal, Amanda Kallen, Natu Mmbaga, Lubna Pal

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Purpose: To determine if blood type in infertile women relates to the likelihood for live birth (LB) following IVF, and to the etiology for infertility. Methods: Retrospective study of patients undergoing IVF at two academic centers in the northeast US. Relationships between blood type (A, B, AB, O) and patient characteristics, IVF cycle parameters and LB were assessed utilizing multivariable logistic regression analyses. Results: In the studied population (n = 626), women with type O were significantly more likely to have baseline FSH > 10 IU/L after adjusting for age, BMI and race (OR 5.09, 95 % CI 1.4–18.7, p = 0.01). Conversely, women with blood type A were significantly more likely to have ovulatory infertility compared to those with blood type O after adjusting for age and BMI (OR 3.2, 95 % CI 1.7–6.2). Blood type B was associated with increased likelihood of live birth (OR 1.9, 95 % CI 1.10–3.41, p = 0.03) after adjusting for factors recognized to impact IVF outcome. Conclusion: Ovulatory infertility and baseline FSH > 10 IU/L were more prevalent in women with blood type A and O respectively. However, those of blood type B had significantly higher odds for LB compared to other blood types after adjusting for factors recognized to impact on IVF cycle outcome. While underlying mechanisms are unclear, for infertile women, patient’s blood type is seemingly relevant for IVF cycle outcome.

Original languageEnglish (US)
Pages (from-to)551-555
Number of pages5
JournalJournal of Assisted Reproduction and Genetics
Volume32
Issue number4
DOIs
StatePublished - Apr 1 2015

Keywords

  • Blood type
  • IVF
  • Infertility
  • Live birth
  • Ovulatory dysfunction

ASJC Scopus subject areas

  • Reproductive Medicine
  • Genetics
  • Obstetrics and Gynecology
  • Developmental Biology
  • Genetics(clinical)

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