Blood monocytes: Distinct subsets, how they relate to dendritic cells, and their possible roles in the regulation of T-cell responses

Frederic Geissmann, Cedric Auffray, Roger Palframan, Christiane Wirrig, Alice Ciocca, Laura Campisi, Emilie Narni-Mancinelli, Gregoire Lauvau

Research output: Contribution to journalArticle

273 Citations (Scopus)

Abstract

Monocytes can have important effects on the polarization and expansion of lymphocytes and may contribute to shaping primary and memory T-cell responses in humans and mice. However, their precise contribution in terms of cellular subsets and the molecular mechanisms involved remains to be determined. Mouse monocytes originate from a bone marrow progenitor, the macrophage and DC precursor (MDP), which also gives rise to conventional dendritic cells through a separate differentiation pathway. Mouse monocytes may be grouped in different functional subsets. The CD115+ Gr1+ 'inflammatory' monocyte subset can give rise not only to immunostimulatory 'TipDCs' in infected mice but also to immunosuppressive 'myeloid-derived suppressor cells' in tumor-bearing mice. CD115+ Gr1+ monocytes can also contribute to the renewal of several resident subsets of macrophages and DCs, such as microglia and Langerhans cells, in inflammatory conditions. The CD115+ Gr1- 'resident' monocyte subset patrols blood vessels in the steady state and extravasates during infection with Listeria monocytogenes or in the healing myocardium. CD115+ Gr1- monocytes are responsible for an early and transient inflammatory burst during Lm infection, which may play a role in the recruitment of other effector cells and subsequently differentiate toward 'M2'-like macrophages that may be involved in wound healing. More research will no doubt confirm the existence of more functional subsets, the developmental relationship between mouse subsets as well as the correspondence between mouse subsets and human subsets of monocytes. We will discuss here the potential roles of monocytes in the immune response, the existence of functional subsets and their relationship with other myeloid cells, including dendritic cells.

Original languageEnglish (US)
Pages (from-to)398-408
Number of pages11
JournalImmunology and Cell Biology
Volume86
Issue number5
DOIs
StatePublished - Jul 2008
Externally publishedYes

Fingerprint

T-cells
Macrophages
Dendritic Cells
Monocytes
Blood
T-Lymphocytes
Bearings (structural)
Listeria
Lymphocytes
Blood vessels
Immunosuppressive Agents
Tumors
Bone
Polarization
Data storage equipment
Langerhans Cells
Listeria monocytogenes
Microglia
Myeloid Cells
Infection

Keywords

  • Dendritic cells
  • Inflammatory
  • Listeria monocytogenes
  • Monocytes
  • Patrolling
  • Subsets

ASJC Scopus subject areas

  • Immunology
  • Clinical Biochemistry
  • Cell Biology

Cite this

Blood monocytes : Distinct subsets, how they relate to dendritic cells, and their possible roles in the regulation of T-cell responses. / Geissmann, Frederic; Auffray, Cedric; Palframan, Roger; Wirrig, Christiane; Ciocca, Alice; Campisi, Laura; Narni-Mancinelli, Emilie; Lauvau, Gregoire.

In: Immunology and Cell Biology, Vol. 86, No. 5, 07.2008, p. 398-408.

Research output: Contribution to journalArticle

Geissmann, Frederic ; Auffray, Cedric ; Palframan, Roger ; Wirrig, Christiane ; Ciocca, Alice ; Campisi, Laura ; Narni-Mancinelli, Emilie ; Lauvau, Gregoire. / Blood monocytes : Distinct subsets, how they relate to dendritic cells, and their possible roles in the regulation of T-cell responses. In: Immunology and Cell Biology. 2008 ; Vol. 86, No. 5. pp. 398-408.
@article{e50e80c024fa4919906397fbe140794c,
title = "Blood monocytes: Distinct subsets, how they relate to dendritic cells, and their possible roles in the regulation of T-cell responses",
abstract = "Monocytes can have important effects on the polarization and expansion of lymphocytes and may contribute to shaping primary and memory T-cell responses in humans and mice. However, their precise contribution in terms of cellular subsets and the molecular mechanisms involved remains to be determined. Mouse monocytes originate from a bone marrow progenitor, the macrophage and DC precursor (MDP), which also gives rise to conventional dendritic cells through a separate differentiation pathway. Mouse monocytes may be grouped in different functional subsets. The CD115+ Gr1+ 'inflammatory' monocyte subset can give rise not only to immunostimulatory 'TipDCs' in infected mice but also to immunosuppressive 'myeloid-derived suppressor cells' in tumor-bearing mice. CD115+ Gr1+ monocytes can also contribute to the renewal of several resident subsets of macrophages and DCs, such as microglia and Langerhans cells, in inflammatory conditions. The CD115+ Gr1- 'resident' monocyte subset patrols blood vessels in the steady state and extravasates during infection with Listeria monocytogenes or in the healing myocardium. CD115+ Gr1- monocytes are responsible for an early and transient inflammatory burst during Lm infection, which may play a role in the recruitment of other effector cells and subsequently differentiate toward 'M2'-like macrophages that may be involved in wound healing. More research will no doubt confirm the existence of more functional subsets, the developmental relationship between mouse subsets as well as the correspondence between mouse subsets and human subsets of monocytes. We will discuss here the potential roles of monocytes in the immune response, the existence of functional subsets and their relationship with other myeloid cells, including dendritic cells.",
keywords = "Dendritic cells, Inflammatory, Listeria monocytogenes, Monocytes, Patrolling, Subsets",
author = "Frederic Geissmann and Cedric Auffray and Roger Palframan and Christiane Wirrig and Alice Ciocca and Laura Campisi and Emilie Narni-Mancinelli and Gregoire Lauvau",
year = "2008",
month = "7",
doi = "10.1038/icb.2008.19",
language = "English (US)",
volume = "86",
pages = "398--408",
journal = "Immunology and Cell Biology",
issn = "0818-9641",
publisher = "Nature Publishing Group",
number = "5",

}

TY - JOUR

T1 - Blood monocytes

T2 - Distinct subsets, how they relate to dendritic cells, and their possible roles in the regulation of T-cell responses

AU - Geissmann, Frederic

AU - Auffray, Cedric

AU - Palframan, Roger

AU - Wirrig, Christiane

AU - Ciocca, Alice

AU - Campisi, Laura

AU - Narni-Mancinelli, Emilie

AU - Lauvau, Gregoire

PY - 2008/7

Y1 - 2008/7

N2 - Monocytes can have important effects on the polarization and expansion of lymphocytes and may contribute to shaping primary and memory T-cell responses in humans and mice. However, their precise contribution in terms of cellular subsets and the molecular mechanisms involved remains to be determined. Mouse monocytes originate from a bone marrow progenitor, the macrophage and DC precursor (MDP), which also gives rise to conventional dendritic cells through a separate differentiation pathway. Mouse monocytes may be grouped in different functional subsets. The CD115+ Gr1+ 'inflammatory' monocyte subset can give rise not only to immunostimulatory 'TipDCs' in infected mice but also to immunosuppressive 'myeloid-derived suppressor cells' in tumor-bearing mice. CD115+ Gr1+ monocytes can also contribute to the renewal of several resident subsets of macrophages and DCs, such as microglia and Langerhans cells, in inflammatory conditions. The CD115+ Gr1- 'resident' monocyte subset patrols blood vessels in the steady state and extravasates during infection with Listeria monocytogenes or in the healing myocardium. CD115+ Gr1- monocytes are responsible for an early and transient inflammatory burst during Lm infection, which may play a role in the recruitment of other effector cells and subsequently differentiate toward 'M2'-like macrophages that may be involved in wound healing. More research will no doubt confirm the existence of more functional subsets, the developmental relationship between mouse subsets as well as the correspondence between mouse subsets and human subsets of monocytes. We will discuss here the potential roles of monocytes in the immune response, the existence of functional subsets and their relationship with other myeloid cells, including dendritic cells.

AB - Monocytes can have important effects on the polarization and expansion of lymphocytes and may contribute to shaping primary and memory T-cell responses in humans and mice. However, their precise contribution in terms of cellular subsets and the molecular mechanisms involved remains to be determined. Mouse monocytes originate from a bone marrow progenitor, the macrophage and DC precursor (MDP), which also gives rise to conventional dendritic cells through a separate differentiation pathway. Mouse monocytes may be grouped in different functional subsets. The CD115+ Gr1+ 'inflammatory' monocyte subset can give rise not only to immunostimulatory 'TipDCs' in infected mice but also to immunosuppressive 'myeloid-derived suppressor cells' in tumor-bearing mice. CD115+ Gr1+ monocytes can also contribute to the renewal of several resident subsets of macrophages and DCs, such as microglia and Langerhans cells, in inflammatory conditions. The CD115+ Gr1- 'resident' monocyte subset patrols blood vessels in the steady state and extravasates during infection with Listeria monocytogenes or in the healing myocardium. CD115+ Gr1- monocytes are responsible for an early and transient inflammatory burst during Lm infection, which may play a role in the recruitment of other effector cells and subsequently differentiate toward 'M2'-like macrophages that may be involved in wound healing. More research will no doubt confirm the existence of more functional subsets, the developmental relationship between mouse subsets as well as the correspondence between mouse subsets and human subsets of monocytes. We will discuss here the potential roles of monocytes in the immune response, the existence of functional subsets and their relationship with other myeloid cells, including dendritic cells.

KW - Dendritic cells

KW - Inflammatory

KW - Listeria monocytogenes

KW - Monocytes

KW - Patrolling

KW - Subsets

UR - http://www.scopus.com/inward/record.url?scp=46749135222&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=46749135222&partnerID=8YFLogxK

U2 - 10.1038/icb.2008.19

DO - 10.1038/icb.2008.19

M3 - Article

C2 - 18392044

AN - SCOPUS:46749135222

VL - 86

SP - 398

EP - 408

JO - Immunology and Cell Biology

JF - Immunology and Cell Biology

SN - 0818-9641

IS - 5

ER -