Blood-Brain Barriers: From Ontogeny to Artificial Interfaces

Rolf Dermietzel, David C. Spray, Maiken Nedergaard

Research output: Book/ReportBook

8 Citations (Scopus)

Abstract

This first handbook to integrate developmental and cellular aspects combines the different structural and functional features involved in the regulation of brain perfusion and neuronal function. It highlights pharmacological and biomedical applications with sections on drug delivery and disease-related states as well as explaining in detail the role of astrocytes, shown to be an essential link between neurons and cerebral blood vessels. In addition the book studies how the structural elements interact in response to the dynamics of neuronal activities, necessitating adaptive mechanism of the interface. A significant part of the book describes new approaches to how the barrier can be surmised for drug delivery and how it can be mimicked by artificial in vitro systems for drug testing. Finally, the involvement of the barrier in brain diseases is considered, focusing on inflammatory and neurodegenerative disorders of the brain. Covering basic knowledge as well as specific information dealing with very recent progress in blood-brain interface research, this book will be of interest to a broad audience.

Original languageEnglish (US)
PublisherJohn Wiley and Sons
Number of pages741
ISBN (Print)3527310886, 9783527310883
DOIs
StatePublished - May 31 2007

Fingerprint

Blood-Brain Barrier
Brain
Pharmaceutical Preparations
Brain Diseases
Astrocytes
Neurodegenerative Diseases
Blood Vessels
Perfusion
Pharmacology
Neurons
Research

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Blood-Brain Barriers : From Ontogeny to Artificial Interfaces. / Dermietzel, Rolf; Spray, David C.; Nedergaard, Maiken.

John Wiley and Sons, 2007. 741 p.

Research output: Book/ReportBook

Dermietzel, Rolf ; Spray, David C. ; Nedergaard, Maiken. / Blood-Brain Barriers : From Ontogeny to Artificial Interfaces. John Wiley and Sons, 2007. 741 p.
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