Blood γδ T cells, Campylobacter jejuni, and GM1 titers in Guillain-Barré syndrome

Stephen N. Scelsa, Violette Ghali, Steven Herskovitz, Phyllis L. Bieri, Deborah L. Shank, Daniel D J MacGowan, Sally Liau

Research output: Contribution to journalArticle

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Abstract

The γδ T cells participate in microbial defense, are prevalent in intestinal epithelia, and are activated in autoimmune diseases. We studied whether peripheral blood γδ cells and γδ subsets are increased in Guillain-Barré syndrome (GBS) and whether elevations are associated with Campylobacter jejuni infection or GM1 elevations. In 20 GBS patients, we performed serial flow cytometry studies of blood γδ, Vδ1, and Vδ2 cells (±CD8+), C jejuni, and ganglioside titers. There was no significant difference in median γδ T-cell percentages between GBS patients and controls at onset and at convalescence. However, 5 patients had marked Vδ1/Cδ8+ elevations. Elevated Vδ1 or Vδ1/Cδ8+ cells occurred in 3 of 6 patients with C jejuni or GM1 titer elevations. A minority of GBS patients have elevations of Vδ1/CD8+ cells, possibly associated with elevated Cjejuni or GM1 titers. The γδ T cells may have a cytotoxic (or suppressor) role in the disease.

Original languageEnglish (US)
Pages (from-to)423-432
Number of pages10
JournalMuscle and Nerve
Volume30
Issue number4
DOIs
StatePublished - Oct 2004

Fingerprint

Campylobacter jejuni
Blood Cells
T-Lymphocytes
Campylobacter Infections
Gangliosides
Intestinal Mucosa
Autoimmune Diseases
Flow Cytometry

Keywords

  • γδ T cells
  • Campylobacter jejuni
  • Gangliosides
  • GM1
  • Guillain-Barré syndrome

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Blood γδ T cells, Campylobacter jejuni, and GM1 titers in Guillain-Barré syndrome. / Scelsa, Stephen N.; Ghali, Violette; Herskovitz, Steven; Bieri, Phyllis L.; Shank, Deborah L.; MacGowan, Daniel D J; Liau, Sally.

In: Muscle and Nerve, Vol. 30, No. 4, 10.2004, p. 423-432.

Research output: Contribution to journalArticle

Scelsa, Stephen N. ; Ghali, Violette ; Herskovitz, Steven ; Bieri, Phyllis L. ; Shank, Deborah L. ; MacGowan, Daniel D J ; Liau, Sally. / Blood γδ T cells, Campylobacter jejuni, and GM1 titers in Guillain-Barré syndrome. In: Muscle and Nerve. 2004 ; Vol. 30, No. 4. pp. 423-432.
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