Abstract
The exogenous administration of the brain/gut peptide cholecystokinin (CCK) inhibits food intake in a variety of species, including subhuman primates and humans. To determine the role of endogenously released CCK in the control of food intake in rhesus monkeys, we examined the ability of the selective type A and type B CCK antagonists devazepide and L-365260 to affect total daily food intake and various meal patterns. Various doses of the antagonists were administered intragastrically 30 min before a daily 4-h feeding period. One-gram food pellets were delivered in response to lever pulls, and intake was computer monitored. Intragastric administration of the type A CCK receptor antagonist devazepide (10-320 μg/kg) significantly increased food intake in a dose-related fashion. The threshold for increasing intake was 32 μg/kg, and a maximal effect was obtained at a dose of 100 μg/kg that increased total 4-h food intake by 47%. The effect of devazepide on food intake was mediated by significant increases in the size and duration of the initial meal, lengthening of the subsequent intermeal interval, and a decrease in the satiety ratio (intermeal interval/1st meal size). In contrast, intragastric administration of the type B CCK receptor antagonist L-365260 (3.2-320 μg/kg) did not significantly affect total food intake or any of the meal parameters. These data demonstrate that endogenously released CCK acting through type A CCK receptors plays a role in regulating food intake in rhesus monkeys.
| Original language | English (US) |
|---|---|
| Journal | American Journal of Physiology - Regulatory Integrative and Comparative Physiology |
| Volume | 265 |
| Issue number | 3 34-3 |
| State | Published - 1993 |
| Externally published | Yes |
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Keywords
- devazepide
- L-365260
- meal patterns
ASJC Scopus subject areas
- Physiology
Cite this
Blockade of type A, but not type B, CCK receptors postpones satiety in rhesus monkeys. / Moran, T. H.; Ameglio, P. J.; Peyton, H. J.; Schwartz, Gary J.; McHugh, P. R.
In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 265, No. 3 34-3, 1993.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Blockade of type A, but not type B, CCK receptors postpones satiety in rhesus monkeys
AU - Moran, T. H.
AU - Ameglio, P. J.
AU - Peyton, H. J.
AU - Schwartz, Gary J.
AU - McHugh, P. R.
PY - 1993
Y1 - 1993
N2 - The exogenous administration of the brain/gut peptide cholecystokinin (CCK) inhibits food intake in a variety of species, including subhuman primates and humans. To determine the role of endogenously released CCK in the control of food intake in rhesus monkeys, we examined the ability of the selective type A and type B CCK antagonists devazepide and L-365260 to affect total daily food intake and various meal patterns. Various doses of the antagonists were administered intragastrically 30 min before a daily 4-h feeding period. One-gram food pellets were delivered in response to lever pulls, and intake was computer monitored. Intragastric administration of the type A CCK receptor antagonist devazepide (10-320 μg/kg) significantly increased food intake in a dose-related fashion. The threshold for increasing intake was 32 μg/kg, and a maximal effect was obtained at a dose of 100 μg/kg that increased total 4-h food intake by 47%. The effect of devazepide on food intake was mediated by significant increases in the size and duration of the initial meal, lengthening of the subsequent intermeal interval, and a decrease in the satiety ratio (intermeal interval/1st meal size). In contrast, intragastric administration of the type B CCK receptor antagonist L-365260 (3.2-320 μg/kg) did not significantly affect total food intake or any of the meal parameters. These data demonstrate that endogenously released CCK acting through type A CCK receptors plays a role in regulating food intake in rhesus monkeys.
AB - The exogenous administration of the brain/gut peptide cholecystokinin (CCK) inhibits food intake in a variety of species, including subhuman primates and humans. To determine the role of endogenously released CCK in the control of food intake in rhesus monkeys, we examined the ability of the selective type A and type B CCK antagonists devazepide and L-365260 to affect total daily food intake and various meal patterns. Various doses of the antagonists were administered intragastrically 30 min before a daily 4-h feeding period. One-gram food pellets were delivered in response to lever pulls, and intake was computer monitored. Intragastric administration of the type A CCK receptor antagonist devazepide (10-320 μg/kg) significantly increased food intake in a dose-related fashion. The threshold for increasing intake was 32 μg/kg, and a maximal effect was obtained at a dose of 100 μg/kg that increased total 4-h food intake by 47%. The effect of devazepide on food intake was mediated by significant increases in the size and duration of the initial meal, lengthening of the subsequent intermeal interval, and a decrease in the satiety ratio (intermeal interval/1st meal size). In contrast, intragastric administration of the type B CCK receptor antagonist L-365260 (3.2-320 μg/kg) did not significantly affect total food intake or any of the meal parameters. These data demonstrate that endogenously released CCK acting through type A CCK receptors plays a role in regulating food intake in rhesus monkeys.
KW - devazepide
KW - L-365260
KW - meal patterns
UR - http://www.scopus.com/inward/record.url?scp=0027435239&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027435239&partnerID=8YFLogxK
M3 - Article
C2 - 8214156
AN - SCOPUS:0027435239
VL - 265
JO - American Journal of Physiology - Renal Fluid and Electrolyte Physiology
JF - American Journal of Physiology - Renal Fluid and Electrolyte Physiology
SN - 1931-857X
IS - 3 34-3
ER -