Blockade of androgen receptors is sufficient to alter the sexual differentiation of the substantia nigra pars reticulata seizure-controlling network

James G. Heida, Jana Velíšková, Solomon L. Moshe

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The substantia nigra pars reticulata (SNR) controls seizures in a sex-specific manner. At postnatal day 15 (P15), SNR infusion of GABAA receptor agonist muscimol have proconvulsant effects in males but not in females. In males, administration of an androgen receptor antagonist flutamide between P0-P2 led to the disappearance of the proconvulsant muscimol effects at P15. Thus, activation of androgen receptors is important for the presence of proconvulsant SNR muscimol responses.

Original languageEnglish (US)
Pages (from-to)8-12
Number of pages5
JournalEpileptic Disorders
Volume10
Issue number1
DOIs
StatePublished - Mar 2008

Fingerprint

Sex Differentiation
Muscimol
Androgen Receptors
Seizures
Androgen Receptor Antagonists
GABA-A Receptor Agonists
Flutamide
Pars Reticulata

Keywords

  • Development
  • Flutamide
  • GABA
  • Rat
  • Substantia nigra

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Blockade of androgen receptors is sufficient to alter the sexual differentiation of the substantia nigra pars reticulata seizure-controlling network. / Heida, James G.; Velíšková, Jana; Moshe, Solomon L.

In: Epileptic Disorders, Vol. 10, No. 1, 03.2008, p. 8-12.

Research output: Contribution to journalArticle

@article{a6f70f79233c4ffcb19380d02e7ba140,
title = "Blockade of androgen receptors is sufficient to alter the sexual differentiation of the substantia nigra pars reticulata seizure-controlling network",
abstract = "The substantia nigra pars reticulata (SNR) controls seizures in a sex-specific manner. At postnatal day 15 (P15), SNR infusion of GABAA receptor agonist muscimol have proconvulsant effects in males but not in females. In males, administration of an androgen receptor antagonist flutamide between P0-P2 led to the disappearance of the proconvulsant muscimol effects at P15. Thus, activation of androgen receptors is important for the presence of proconvulsant SNR muscimol responses.",
keywords = "Development, Flutamide, GABA, Rat, Substantia nigra",
author = "Heida, {James G.} and Jana Vel{\'i}škov{\'a} and Moshe, {Solomon L.}",
year = "2008",
month = "3",
doi = "10.1684/epd.2008.0160",
language = "English (US)",
volume = "10",
pages = "8--12",
journal = "Epileptic Disorders",
issn = "1294-9361",
publisher = "Springer Paris",
number = "1",

}

TY - JOUR

T1 - Blockade of androgen receptors is sufficient to alter the sexual differentiation of the substantia nigra pars reticulata seizure-controlling network

AU - Heida, James G.

AU - Velíšková, Jana

AU - Moshe, Solomon L.

PY - 2008/3

Y1 - 2008/3

N2 - The substantia nigra pars reticulata (SNR) controls seizures in a sex-specific manner. At postnatal day 15 (P15), SNR infusion of GABAA receptor agonist muscimol have proconvulsant effects in males but not in females. In males, administration of an androgen receptor antagonist flutamide between P0-P2 led to the disappearance of the proconvulsant muscimol effects at P15. Thus, activation of androgen receptors is important for the presence of proconvulsant SNR muscimol responses.

AB - The substantia nigra pars reticulata (SNR) controls seizures in a sex-specific manner. At postnatal day 15 (P15), SNR infusion of GABAA receptor agonist muscimol have proconvulsant effects in males but not in females. In males, administration of an androgen receptor antagonist flutamide between P0-P2 led to the disappearance of the proconvulsant muscimol effects at P15. Thus, activation of androgen receptors is important for the presence of proconvulsant SNR muscimol responses.

KW - Development

KW - Flutamide

KW - GABA

KW - Rat

KW - Substantia nigra

UR - http://www.scopus.com/inward/record.url?scp=41949111926&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=41949111926&partnerID=8YFLogxK

U2 - 10.1684/epd.2008.0160

DO - 10.1684/epd.2008.0160

M3 - Article

VL - 10

SP - 8

EP - 12

JO - Epileptic Disorders

JF - Epileptic Disorders

SN - 1294-9361

IS - 1

ER -