Blockade of androgen receptors is sufficient to alter the sexual differentiation of the substantia nigra pars reticulata seizure-controlling network

James G. Heida, Jana Velíšková, Solomon L. Moshé

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

The substantia nigra pars reticulata (SNR) controls seizures in a sex-specific manner. At postnatal day 15 (P15), SNR infusion of GABAA receptor agonist muscimol have proconvulsant effects in males but not in females. In males, administration of an androgen receptor antagonist flutamide between P0-P2 led to the disappearance of the proconvulsant muscimol effects at P15. Thus, activation of androgen receptors is important for the presence of proconvulsant SNR muscimol responses.

Original languageEnglish (US)
Pages (from-to)8-12
Number of pages5
JournalEpileptic Disorders
Volume10
Issue number1
DOIs
StatePublished - Mar 2008

Keywords

  • Development
  • Flutamide
  • GABA
  • Rat
  • Substantia nigra

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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