Blastulation rates decline in a linear fashion from euploid to aneuploid embryos with single versus multiple chromosomal errors

Mario Vega, Andrzej Breborowicz, Erin L. Moshier, Peter G. McGovern, Martin D. Keltz

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Objective To test the hypothesis that the blastulation rate is higher in euploid embryos than in aneuploid embryos as assessed by cleavage-stage biopsy with array-comprehensive genomic hybridization (aCGH). Design Retrospective cohort study. Setting University-affiliated institution. Patient(s) Forty-one patients with 48 in vitro fertilization (IVF) cycles and 385 embryos that underwent cleavage-stage preimplantation genetic screening (PGS) with aCGH at the Continuum Reproductive Center between January 2010 and September 2013. Intervention(s) None. Main Outcome Measure(s) Probability of blastocyst and/or fully expanded or hatching blastocyst (FEHB) progression depending on number of chromosomal abnormalities. Result(s) Euploid embryos are twice as likely to progress to blastocyst and three times as likely to progress to FEHB than aneuploid embryos: 76% versus 37% and 56% versus 18%, respectively. For every additional chromosomal abnormality, the likelihood of progressing to the blastocyst stage decreases by 22% and the likelihood of progressing to FEHB decreases by 33%. Conclusion(s) Euploid embryos are far more likely than aneuploid embryos to progress to the blastocyst and FEHB stages. There is a linear decrease in probability of blastulation with the increasing number of chromosomal abnormalities.

Original languageEnglish (US)
Pages (from-to)394-398
Number of pages5
JournalFertility and Sterility
Volume102
Issue number2
DOIs
StatePublished - 2014
Externally publishedYes

Fingerprint

Blastocyst
Aneuploidy
Embryonic Structures
Chromosome Aberrations
Nucleic Acid Hybridization
Preimplantation Diagnosis
Genetic Testing
Fertilization in Vitro
Cohort Studies
Retrospective Studies
Outcome Assessment (Health Care)
Biopsy

Keywords

  • Aneuploidy
  • assisted reproduction
  • embryo quality
  • PGS
  • preimplantation genetic screening

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Reproductive Medicine

Cite this

Blastulation rates decline in a linear fashion from euploid to aneuploid embryos with single versus multiple chromosomal errors. / Vega, Mario; Breborowicz, Andrzej; Moshier, Erin L.; McGovern, Peter G.; Keltz, Martin D.

In: Fertility and Sterility, Vol. 102, No. 2, 2014, p. 394-398.

Research output: Contribution to journalArticle

Vega, Mario ; Breborowicz, Andrzej ; Moshier, Erin L. ; McGovern, Peter G. ; Keltz, Martin D. / Blastulation rates decline in a linear fashion from euploid to aneuploid embryos with single versus multiple chromosomal errors. In: Fertility and Sterility. 2014 ; Vol. 102, No. 2. pp. 394-398.
@article{beab2afc3a1642b58f5ee3c06ed95def,
title = "Blastulation rates decline in a linear fashion from euploid to aneuploid embryos with single versus multiple chromosomal errors",
abstract = "Objective To test the hypothesis that the blastulation rate is higher in euploid embryos than in aneuploid embryos as assessed by cleavage-stage biopsy with array-comprehensive genomic hybridization (aCGH). Design Retrospective cohort study. Setting University-affiliated institution. Patient(s) Forty-one patients with 48 in vitro fertilization (IVF) cycles and 385 embryos that underwent cleavage-stage preimplantation genetic screening (PGS) with aCGH at the Continuum Reproductive Center between January 2010 and September 2013. Intervention(s) None. Main Outcome Measure(s) Probability of blastocyst and/or fully expanded or hatching blastocyst (FEHB) progression depending on number of chromosomal abnormalities. Result(s) Euploid embryos are twice as likely to progress to blastocyst and three times as likely to progress to FEHB than aneuploid embryos: 76{\%} versus 37{\%} and 56{\%} versus 18{\%}, respectively. For every additional chromosomal abnormality, the likelihood of progressing to the blastocyst stage decreases by 22{\%} and the likelihood of progressing to FEHB decreases by 33{\%}. Conclusion(s) Euploid embryos are far more likely than aneuploid embryos to progress to the blastocyst and FEHB stages. There is a linear decrease in probability of blastulation with the increasing number of chromosomal abnormalities.",
keywords = "Aneuploidy, assisted reproduction, embryo quality, PGS, preimplantation genetic screening",
author = "Mario Vega and Andrzej Breborowicz and Moshier, {Erin L.} and McGovern, {Peter G.} and Keltz, {Martin D.}",
year = "2014",
doi = "10.1016/j.fertnstert.2014.04.026",
language = "English (US)",
volume = "102",
pages = "394--398",
journal = "Fertility and Sterility",
issn = "0015-0282",
publisher = "Elsevier Inc.",
number = "2",

}

TY - JOUR

T1 - Blastulation rates decline in a linear fashion from euploid to aneuploid embryos with single versus multiple chromosomal errors

AU - Vega, Mario

AU - Breborowicz, Andrzej

AU - Moshier, Erin L.

AU - McGovern, Peter G.

AU - Keltz, Martin D.

PY - 2014

Y1 - 2014

N2 - Objective To test the hypothesis that the blastulation rate is higher in euploid embryos than in aneuploid embryos as assessed by cleavage-stage biopsy with array-comprehensive genomic hybridization (aCGH). Design Retrospective cohort study. Setting University-affiliated institution. Patient(s) Forty-one patients with 48 in vitro fertilization (IVF) cycles and 385 embryos that underwent cleavage-stage preimplantation genetic screening (PGS) with aCGH at the Continuum Reproductive Center between January 2010 and September 2013. Intervention(s) None. Main Outcome Measure(s) Probability of blastocyst and/or fully expanded or hatching blastocyst (FEHB) progression depending on number of chromosomal abnormalities. Result(s) Euploid embryos are twice as likely to progress to blastocyst and three times as likely to progress to FEHB than aneuploid embryos: 76% versus 37% and 56% versus 18%, respectively. For every additional chromosomal abnormality, the likelihood of progressing to the blastocyst stage decreases by 22% and the likelihood of progressing to FEHB decreases by 33%. Conclusion(s) Euploid embryos are far more likely than aneuploid embryos to progress to the blastocyst and FEHB stages. There is a linear decrease in probability of blastulation with the increasing number of chromosomal abnormalities.

AB - Objective To test the hypothesis that the blastulation rate is higher in euploid embryos than in aneuploid embryos as assessed by cleavage-stage biopsy with array-comprehensive genomic hybridization (aCGH). Design Retrospective cohort study. Setting University-affiliated institution. Patient(s) Forty-one patients with 48 in vitro fertilization (IVF) cycles and 385 embryos that underwent cleavage-stage preimplantation genetic screening (PGS) with aCGH at the Continuum Reproductive Center between January 2010 and September 2013. Intervention(s) None. Main Outcome Measure(s) Probability of blastocyst and/or fully expanded or hatching blastocyst (FEHB) progression depending on number of chromosomal abnormalities. Result(s) Euploid embryos are twice as likely to progress to blastocyst and three times as likely to progress to FEHB than aneuploid embryos: 76% versus 37% and 56% versus 18%, respectively. For every additional chromosomal abnormality, the likelihood of progressing to the blastocyst stage decreases by 22% and the likelihood of progressing to FEHB decreases by 33%. Conclusion(s) Euploid embryos are far more likely than aneuploid embryos to progress to the blastocyst and FEHB stages. There is a linear decrease in probability of blastulation with the increasing number of chromosomal abnormalities.

KW - Aneuploidy

KW - assisted reproduction

KW - embryo quality

KW - PGS

KW - preimplantation genetic screening

UR - http://www.scopus.com/inward/record.url?scp=84905500860&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84905500860&partnerID=8YFLogxK

U2 - 10.1016/j.fertnstert.2014.04.026

DO - 10.1016/j.fertnstert.2014.04.026

M3 - Article

C2 - 24890269

AN - SCOPUS:84905500860

VL - 102

SP - 394

EP - 398

JO - Fertility and Sterility

JF - Fertility and Sterility

SN - 0015-0282

IS - 2

ER -