Blastocystis

To treat or not to treat..

Christina M. Coyle, Julie Varughese, Louis M. Weiss, Herbert B. Tanowitz

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

Parasites in the genus Blastocystis comprise several subtypes (genotypes) and have a worldwide distribution. In some surveys, these are the most common parasites found in human stool specimens. An emerging literature suggests that the pathogenicity of Blastocystis is related to specific subtypes and parasite burden, although even individuals with small numbers of cysts may be symptomatic. Some data suggest an association between infection with Blastocystis and irritable bowel syndrome. However, there are few clinical studies demonstrating a direct relationship between the presence of this parasite and disease, few animal models to explore this relationship, and no consensus as to appropriate treatment. We recommend that asymptomatic individuals with few cysts not be treated. However, those who have gastrointestinal or dermatologic signs and symptoms and many cysts in stool specimens may require treatment. Metronidazole is the drug of choice. Additional studies are required to determine pathogenicity and appropriate therapy.

Original languageEnglish (US)
Pages (from-to)105-110
Number of pages6
JournalClinical Infectious Diseases
Volume54
Issue number1
DOIs
StatePublished - Jan 1 2012

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Blastocystis
Parasites
Cysts
Virulence
Blastocystis Infections
Animal Disease Models
Irritable Bowel Syndrome
Metronidazole
Signs and Symptoms
Genotype
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Infectious Diseases
  • Microbiology (medical)

Cite this

Blastocystis : To treat or not to treat.. / Coyle, Christina M.; Varughese, Julie; Weiss, Louis M.; Tanowitz, Herbert B.

In: Clinical Infectious Diseases, Vol. 54, No. 1, 01.01.2012, p. 105-110.

Research output: Contribution to journalArticle

Coyle, Christina M. ; Varughese, Julie ; Weiss, Louis M. ; Tanowitz, Herbert B. / Blastocystis : To treat or not to treat.. In: Clinical Infectious Diseases. 2012 ; Vol. 54, No. 1. pp. 105-110.
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