Blastocyst expansion score and trophectoderm morphology strongly predict successful clinical pregnancy and live birth following elective single embryo blastocyst transfer (eSET): A national study

Stephanie Marshall Thompson, Ndidiamaka Onwubalili, Kelecia Brown, Sangita K. Jindal, Peter G. McGovern

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Purpose: To determine which characteristics of blastocyst embryo morphology may predict clinical pregnancy and live birth rates. Methods: A retrospective analysis of data from 3,151 cycles of fresh, non-donor eSET cycles from 2008 to 2009 was performed. Data were obtained from the Society for Assisted Reproductive Technologies (SART) underwent. All eSET were performed at the blastocyst stage. Main outcome measures were clinical pregnancy and live birth rates. Results: Trophectoderm morphology, embryo stage and patient age are highly significant independent predictors of both clinical pregnancy and live birth. Neither inner cell mass morphology nor embryo grade predicted clinical pregnancy or live birth. Conclusions: Better trophectoderm morphology, younger patient age and further blastocyst progression all result in higher clinical pregnancy and live birth rates. Therefore, trophectoderm morphology and blastocyst stage should preferentially be used as the most important factors in choosing the best embryo for transfer.

Original languageEnglish (US)
Pages (from-to)1577-1581
Number of pages5
JournalJournal of Assisted Reproduction and Genetics
Volume30
Issue number12
DOIs
StatePublished - Dec 2013

Fingerprint

Single Embryo Transfer
Embryo Transfer
Live Birth
Blastocyst
Pregnancy Rate
Pregnancy
Embryonic Structures
Assisted Reproductive Techniques
Outcome Assessment (Health Care)

Keywords

  • Embryo grading
  • Inner cell mass
  • IVF
  • SART
  • Trophectoderm morphology

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Reproductive Medicine
  • Developmental Biology
  • Genetics
  • Genetics(clinical)

Cite this

Blastocyst expansion score and trophectoderm morphology strongly predict successful clinical pregnancy and live birth following elective single embryo blastocyst transfer (eSET) : A national study. / Thompson, Stephanie Marshall; Onwubalili, Ndidiamaka; Brown, Kelecia; Jindal, Sangita K.; McGovern, Peter G.

In: Journal of Assisted Reproduction and Genetics, Vol. 30, No. 12, 12.2013, p. 1577-1581.

Research output: Contribution to journalArticle

@article{010def48bf4046c58895688d093aad5a,
title = "Blastocyst expansion score and trophectoderm morphology strongly predict successful clinical pregnancy and live birth following elective single embryo blastocyst transfer (eSET): A national study",
abstract = "Purpose: To determine which characteristics of blastocyst embryo morphology may predict clinical pregnancy and live birth rates. Methods: A retrospective analysis of data from 3,151 cycles of fresh, non-donor eSET cycles from 2008 to 2009 was performed. Data were obtained from the Society for Assisted Reproductive Technologies (SART) underwent. All eSET were performed at the blastocyst stage. Main outcome measures were clinical pregnancy and live birth rates. Results: Trophectoderm morphology, embryo stage and patient age are highly significant independent predictors of both clinical pregnancy and live birth. Neither inner cell mass morphology nor embryo grade predicted clinical pregnancy or live birth. Conclusions: Better trophectoderm morphology, younger patient age and further blastocyst progression all result in higher clinical pregnancy and live birth rates. Therefore, trophectoderm morphology and blastocyst stage should preferentially be used as the most important factors in choosing the best embryo for transfer.",
keywords = "Embryo grading, Inner cell mass, IVF, SART, Trophectoderm morphology",
author = "Thompson, {Stephanie Marshall} and Ndidiamaka Onwubalili and Kelecia Brown and Jindal, {Sangita K.} and McGovern, {Peter G.}",
year = "2013",
month = "12",
doi = "10.1007/s10815-013-0100-4",
language = "English (US)",
volume = "30",
pages = "1577--1581",
journal = "Journal of Assisted Reproduction and Genetics",
issn = "1058-0468",
publisher = "Springer New York",
number = "12",

}

TY - JOUR

T1 - Blastocyst expansion score and trophectoderm morphology strongly predict successful clinical pregnancy and live birth following elective single embryo blastocyst transfer (eSET)

T2 - A national study

AU - Thompson, Stephanie Marshall

AU - Onwubalili, Ndidiamaka

AU - Brown, Kelecia

AU - Jindal, Sangita K.

AU - McGovern, Peter G.

PY - 2013/12

Y1 - 2013/12

N2 - Purpose: To determine which characteristics of blastocyst embryo morphology may predict clinical pregnancy and live birth rates. Methods: A retrospective analysis of data from 3,151 cycles of fresh, non-donor eSET cycles from 2008 to 2009 was performed. Data were obtained from the Society for Assisted Reproductive Technologies (SART) underwent. All eSET were performed at the blastocyst stage. Main outcome measures were clinical pregnancy and live birth rates. Results: Trophectoderm morphology, embryo stage and patient age are highly significant independent predictors of both clinical pregnancy and live birth. Neither inner cell mass morphology nor embryo grade predicted clinical pregnancy or live birth. Conclusions: Better trophectoderm morphology, younger patient age and further blastocyst progression all result in higher clinical pregnancy and live birth rates. Therefore, trophectoderm morphology and blastocyst stage should preferentially be used as the most important factors in choosing the best embryo for transfer.

AB - Purpose: To determine which characteristics of blastocyst embryo morphology may predict clinical pregnancy and live birth rates. Methods: A retrospective analysis of data from 3,151 cycles of fresh, non-donor eSET cycles from 2008 to 2009 was performed. Data were obtained from the Society for Assisted Reproductive Technologies (SART) underwent. All eSET were performed at the blastocyst stage. Main outcome measures were clinical pregnancy and live birth rates. Results: Trophectoderm morphology, embryo stage and patient age are highly significant independent predictors of both clinical pregnancy and live birth. Neither inner cell mass morphology nor embryo grade predicted clinical pregnancy or live birth. Conclusions: Better trophectoderm morphology, younger patient age and further blastocyst progression all result in higher clinical pregnancy and live birth rates. Therefore, trophectoderm morphology and blastocyst stage should preferentially be used as the most important factors in choosing the best embryo for transfer.

KW - Embryo grading

KW - Inner cell mass

KW - IVF

KW - SART

KW - Trophectoderm morphology

UR - http://www.scopus.com/inward/record.url?scp=84890454257&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84890454257&partnerID=8YFLogxK

U2 - 10.1007/s10815-013-0100-4

DO - 10.1007/s10815-013-0100-4

M3 - Article

C2 - 24114628

AN - SCOPUS:84890454257

VL - 30

SP - 1577

EP - 1581

JO - Journal of Assisted Reproduction and Genetics

JF - Journal of Assisted Reproduction and Genetics

SN - 1058-0468

IS - 12

ER -