Bladder irrigation with amphotericin B for treatment of fungal urinary tract infections

Laurie G. Jacobs, Ember A. Skidmore, Lucio A. Cardoso, Francine Ziv

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Fungal urinary tract infection has become a frequent clinical entity. Despite limited evaluation of its efficacy, bladder irrigation with amphotericin B has become the usual means of therapy for such infections. The outcome of treatment with amphotericin B bladder irrigation for an average of 5 days for 95 hospitalized patients with funguria (mean age, 75 years) during a 14-month period is presented. All patients who received treatment were identified from pharmacy records; those for whom urine culture results were obtained after treatment were studied. Fever and/or pyuria was identified in the majority of cases. Funguria was eradicated in 80% (confidence interval, 72%-88%). Concomitant diabetes mellitus or the previous use of indwelling bladder catheters did not alter response to treatment. The mortality rate following treatment of funguria was 39%, compared to 30.5% for a similar population during the same period. Amphotericin B bladder irrigation may not prove to be ideal therapy despite the fact that it initially eradicated funguria in the majority of subjects in this study.

Original languageEnglish (US)
Pages (from-to)313-318
Number of pages6
JournalClinical Infectious Diseases
Volume18
Issue number3
StatePublished - Mar 1994

Fingerprint

Amphotericin B
Urinary Tract Infections
Urinary Bladder
Therapeutics
Pyuria
Indwelling Catheters
Diabetes Mellitus
Fever
Urine
Confidence Intervals
Mortality
Infection
Population

ASJC Scopus subject areas

  • Immunology

Cite this

Jacobs, L. G., Skidmore, E. A., Cardoso, L. A., & Ziv, F. (1994). Bladder irrigation with amphotericin B for treatment of fungal urinary tract infections. Clinical Infectious Diseases, 18(3), 313-318.

Bladder irrigation with amphotericin B for treatment of fungal urinary tract infections. / Jacobs, Laurie G.; Skidmore, Ember A.; Cardoso, Lucio A.; Ziv, Francine.

In: Clinical Infectious Diseases, Vol. 18, No. 3, 03.1994, p. 313-318.

Research output: Contribution to journalArticle

Jacobs, LG, Skidmore, EA, Cardoso, LA & Ziv, F 1994, 'Bladder irrigation with amphotericin B for treatment of fungal urinary tract infections', Clinical Infectious Diseases, vol. 18, no. 3, pp. 313-318.
Jacobs, Laurie G. ; Skidmore, Ember A. ; Cardoso, Lucio A. ; Ziv, Francine. / Bladder irrigation with amphotericin B for treatment of fungal urinary tract infections. In: Clinical Infectious Diseases. 1994 ; Vol. 18, No. 3. pp. 313-318.
@article{25efd485b88147b9942c3e5c8a2c1fb2,
title = "Bladder irrigation with amphotericin B for treatment of fungal urinary tract infections",
abstract = "Fungal urinary tract infection has become a frequent clinical entity. Despite limited evaluation of its efficacy, bladder irrigation with amphotericin B has become the usual means of therapy for such infections. The outcome of treatment with amphotericin B bladder irrigation for an average of 5 days for 95 hospitalized patients with funguria (mean age, 75 years) during a 14-month period is presented. All patients who received treatment were identified from pharmacy records; those for whom urine culture results were obtained after treatment were studied. Fever and/or pyuria was identified in the majority of cases. Funguria was eradicated in 80{\%} (confidence interval, 72{\%}-88{\%}). Concomitant diabetes mellitus or the previous use of indwelling bladder catheters did not alter response to treatment. The mortality rate following treatment of funguria was 39{\%}, compared to 30.5{\%} for a similar population during the same period. Amphotericin B bladder irrigation may not prove to be ideal therapy despite the fact that it initially eradicated funguria in the majority of subjects in this study.",
author = "Jacobs, {Laurie G.} and Skidmore, {Ember A.} and Cardoso, {Lucio A.} and Francine Ziv",
year = "1994",
month = "3",
language = "English (US)",
volume = "18",
pages = "313--318",
journal = "Clinical Infectious Diseases",
issn = "1058-4838",
publisher = "Oxford University Press",
number = "3",

}

TY - JOUR

T1 - Bladder irrigation with amphotericin B for treatment of fungal urinary tract infections

AU - Jacobs, Laurie G.

AU - Skidmore, Ember A.

AU - Cardoso, Lucio A.

AU - Ziv, Francine

PY - 1994/3

Y1 - 1994/3

N2 - Fungal urinary tract infection has become a frequent clinical entity. Despite limited evaluation of its efficacy, bladder irrigation with amphotericin B has become the usual means of therapy for such infections. The outcome of treatment with amphotericin B bladder irrigation for an average of 5 days for 95 hospitalized patients with funguria (mean age, 75 years) during a 14-month period is presented. All patients who received treatment were identified from pharmacy records; those for whom urine culture results were obtained after treatment were studied. Fever and/or pyuria was identified in the majority of cases. Funguria was eradicated in 80% (confidence interval, 72%-88%). Concomitant diabetes mellitus or the previous use of indwelling bladder catheters did not alter response to treatment. The mortality rate following treatment of funguria was 39%, compared to 30.5% for a similar population during the same period. Amphotericin B bladder irrigation may not prove to be ideal therapy despite the fact that it initially eradicated funguria in the majority of subjects in this study.

AB - Fungal urinary tract infection has become a frequent clinical entity. Despite limited evaluation of its efficacy, bladder irrigation with amphotericin B has become the usual means of therapy for such infections. The outcome of treatment with amphotericin B bladder irrigation for an average of 5 days for 95 hospitalized patients with funguria (mean age, 75 years) during a 14-month period is presented. All patients who received treatment were identified from pharmacy records; those for whom urine culture results were obtained after treatment were studied. Fever and/or pyuria was identified in the majority of cases. Funguria was eradicated in 80% (confidence interval, 72%-88%). Concomitant diabetes mellitus or the previous use of indwelling bladder catheters did not alter response to treatment. The mortality rate following treatment of funguria was 39%, compared to 30.5% for a similar population during the same period. Amphotericin B bladder irrigation may not prove to be ideal therapy despite the fact that it initially eradicated funguria in the majority of subjects in this study.

UR - http://www.scopus.com/inward/record.url?scp=0028230018&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028230018&partnerID=8YFLogxK

M3 - Article

C2 - 8011810

AN - SCOPUS:0028230018

VL - 18

SP - 313

EP - 318

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

SN - 1058-4838

IS - 3

ER -