Bispecific antibodies for viral immunotherapy

Elisabeth K. Nyakatura, Alexandra Y. Soare, Jonathan R. Lai

Research output: Contribution to journalReview article

8 Scopus citations

Abstract

Bispecific antibody engineering, in which binding specificities toward 2 distinct epitopes are combined into a single molecule, can greatly enhance immunotherapeutic properties of monoclonal antibodies. While the bispecific antibody approach has been applied widely to targets for indications such as cancer and inflammation, the development of such agents for viral immunotherapy is only now emerging. Here, we review recent advances in the development of bispecific antibodies for viral immunotherapy, highlighting promising in vitro and in vivo results.

Original languageEnglish (US)
Pages (from-to)836-842
Number of pages7
JournalHuman Vaccines and Immunotherapeutics
Volume13
Issue number4
DOIs
StatePublished - Apr 3 2017

Keywords

  • antibody engineering
  • antibody therapeutics
  • antiviral
  • bifunctional antibodies
  • bispecific antibodies
  • immunotherapy
  • passive immunization
  • virology

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pharmacology

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