Birth weight, genetic susceptibility, and adulthood risk of type 2 diabetes

Yanping Li, Qibin Qi, Tsegaselassie Workalemahu, Frank B. Hu, Lu Qi

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

OBJECTIVE - Both stressful intrauterine milieus and genetic susceptibility have been linked to later-life diabetes risk. The current study aims to examine the interaction between low birth weight, a surrogatemeasure of stressful intrauterinemilieus, and genetic susceptibility in relation to risk of type 2 diabetes in adulthood. RESEARCH DESIGN AND METHODS - The analysis included two independent, nested case-control studies of 2,591 type 2 diabetic case subjects and 3,052 healthy control subjects. We developed two genotype scores: an obesity genotype score based on 32 BMI-predisposing variants and a diabetes genotype score based on 35 diabetes-predisposing variants. RESULTS - Obesity genotype scores showed a stronger association with type 2 diabetes risk in individuals with low birth weight. In low-birth weight individuals, the multivariable- adjusted odds ratio (OR) was 2.55 (95% CI 1.34-4.84) by comparing extreme quartiles of the obesity genotype score, while the OR was 1.27 (1.04-1.55) among individuals with birth weight >2.5 kg (P for interaction = 0.017). We did not observe significant interaction between diabetes genotype scores and birth weight with regard to risk of type 2 diabetes. In a comparison of extreme quartiles of the diabetes gene score, the multivariable-adjusted OR was 3.80 (1.76-8.24) among individuals with low birth weight and 2.27 (1.82-2.83) among those with high birth weight (P for interaction = 0.16). CONCLUSIONS - Our data suggest that low birth weight and genetic susceptibility to obesity may synergistically affect adulthood risk of type 2 diabetes.

Original languageEnglish (US)
Pages (from-to)2479-2484
Number of pages6
JournalDiabetes Care
Volume35
Issue number12
DOIs
StatePublished - Dec 2012
Externally publishedYes

Fingerprint

Genetic Predisposition to Disease
Birth Weight
Type 2 Diabetes Mellitus
Low Birth Weight Infant
Genotype
Obesity
Odds Ratio
Case-Control Studies
Healthy Volunteers
Research Design
Genes

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialized Nursing

Cite this

Birth weight, genetic susceptibility, and adulthood risk of type 2 diabetes. / Li, Yanping; Qi, Qibin; Workalemahu, Tsegaselassie; Hu, Frank B.; Qi, Lu.

In: Diabetes Care, Vol. 35, No. 12, 12.2012, p. 2479-2484.

Research output: Contribution to journalArticle

Li, Yanping ; Qi, Qibin ; Workalemahu, Tsegaselassie ; Hu, Frank B. ; Qi, Lu. / Birth weight, genetic susceptibility, and adulthood risk of type 2 diabetes. In: Diabetes Care. 2012 ; Vol. 35, No. 12. pp. 2479-2484.
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