Abstract
A patient in complete remission from malignant melanoma but with refractory anemia after nitrosourea treatment developed acute biphenotypic leukemia. This disease, progression was accompanied by expansion of a cytogenetically abnormal clone. At first cytogenetic analysis, 1 year post discontinuation of chemotherapy, only 25% of the metaphases examined were hydodiploid with monosomy 7. Six months later, all of the metaphase seen were 45,XY, -7. Six months before overt acute leukemia was diagnosed, an additional chromosome abnormality emerged, t(2;3)(q31;q27). Although the translocation was present in all metaphases examined, the patient progressed into an acute leukemia with two components: one TdT-positive, Ia-positive, and the other TdT-negative, Ia-positive, monocytoid antigen-positive. This mixed leukemia was identified by double fluorescence staining for intranuclear TdT and surface labeling with a monocyte-specific monoclonal antibody.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 355-360 |
| Number of pages | 6 |
| Journal | Cancer Genetics and Cytogenetics |
| Volume | 21 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 15 1986 |
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ASJC Scopus subject areas
- Cancer Research
- Genetics
- Molecular Biology
Cite this
Biphenotypic leukemia with unusual chromosomal translocation in a patient treated for melanoma. / Paietta, Elisabeth M.; Papenhausen, Peter; Ciobanu, Niculae; Dutcher, Janice P.; Wiernik, Peter H.
In: Cancer Genetics and Cytogenetics, Vol. 21, No. 4, 15.04.1986, p. 355-360.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Biphenotypic leukemia with unusual chromosomal translocation in a patient treated for melanoma
AU - Paietta, Elisabeth M.
AU - Papenhausen, Peter
AU - Ciobanu, Niculae
AU - Dutcher, Janice P.
AU - Wiernik, Peter H.
PY - 1986/4/15
Y1 - 1986/4/15
N2 - A patient in complete remission from malignant melanoma but with refractory anemia after nitrosourea treatment developed acute biphenotypic leukemia. This disease, progression was accompanied by expansion of a cytogenetically abnormal clone. At first cytogenetic analysis, 1 year post discontinuation of chemotherapy, only 25% of the metaphases examined were hydodiploid with monosomy 7. Six months later, all of the metaphase seen were 45,XY, -7. Six months before overt acute leukemia was diagnosed, an additional chromosome abnormality emerged, t(2;3)(q31;q27). Although the translocation was present in all metaphases examined, the patient progressed into an acute leukemia with two components: one TdT-positive, Ia-positive, and the other TdT-negative, Ia-positive, monocytoid antigen-positive. This mixed leukemia was identified by double fluorescence staining for intranuclear TdT and surface labeling with a monocyte-specific monoclonal antibody.
AB - A patient in complete remission from malignant melanoma but with refractory anemia after nitrosourea treatment developed acute biphenotypic leukemia. This disease, progression was accompanied by expansion of a cytogenetically abnormal clone. At first cytogenetic analysis, 1 year post discontinuation of chemotherapy, only 25% of the metaphases examined were hydodiploid with monosomy 7. Six months later, all of the metaphase seen were 45,XY, -7. Six months before overt acute leukemia was diagnosed, an additional chromosome abnormality emerged, t(2;3)(q31;q27). Although the translocation was present in all metaphases examined, the patient progressed into an acute leukemia with two components: one TdT-positive, Ia-positive, and the other TdT-negative, Ia-positive, monocytoid antigen-positive. This mixed leukemia was identified by double fluorescence staining for intranuclear TdT and surface labeling with a monocyte-specific monoclonal antibody.
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U2 - 10.1016/0165-4608(86)90217-7
DO - 10.1016/0165-4608(86)90217-7
M3 - Article
VL - 21
SP - 355
EP - 360
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
SN - 0165-4608
IS - 4
ER -