Biphenotypic leukemia with unusual chromosomal translocation in a patient treated for melanoma

Elisabeth M. Paietta, Peter Papenhausen, Niculae Ciobanu, Janice P. Dutcher, Peter H. Wiernik

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

A patient in complete remission from malignant melanoma but with refractory anemia after nitrosourea treatment developed acute biphenotypic leukemia. This disease, progression was accompanied by expansion of a cytogenetically abnormal clone. At first cytogenetic analysis, 1 year post discontinuation of chemotherapy, only 25% of the metaphases examined were hydodiploid with monosomy 7. Six months later, all of the metaphase seen were 45,XY, -7. Six months before overt acute leukemia was diagnosed, an additional chromosome abnormality emerged, t(2;3)(q31;q27). Although the translocation was present in all metaphases examined, the patient progressed into an acute leukemia with two components: one TdT-positive, Ia-positive, and the other TdT-negative, Ia-positive, monocytoid antigen-positive. This mixed leukemia was identified by double fluorescence staining for intranuclear TdT and surface labeling with a monocyte-specific monoclonal antibody.

Original languageEnglish (US)
Pages (from-to)355-360
Number of pages6
JournalCancer Genetics and Cytogenetics
Volume21
Issue number4
DOIs
StatePublished - Apr 15 1986

Fingerprint

Genetic Translocation
Metaphase
Melanoma
Leukemia
Biphenotypic Acute Leukemia
Refractory Anemia
Cytogenetic Analysis
Chromosome Aberrations
Disease Progression
Monocytes
Clone Cells
Fluorescence
Monoclonal Antibodies
Staining and Labeling
Antigens
Drug Therapy
Therapeutics

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

Cite this

Biphenotypic leukemia with unusual chromosomal translocation in a patient treated for melanoma. / Paietta, Elisabeth M.; Papenhausen, Peter; Ciobanu, Niculae; Dutcher, Janice P.; Wiernik, Peter H.

In: Cancer Genetics and Cytogenetics, Vol. 21, No. 4, 15.04.1986, p. 355-360.

Research output: Contribution to journalArticle

Paietta, Elisabeth M. ; Papenhausen, Peter ; Ciobanu, Niculae ; Dutcher, Janice P. ; Wiernik, Peter H. / Biphenotypic leukemia with unusual chromosomal translocation in a patient treated for melanoma. In: Cancer Genetics and Cytogenetics. 1986 ; Vol. 21, No. 4. pp. 355-360.
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