Biotinylation of aminopyridine-based macrocycles and metallomacrocycles and inclusion of biotinylated iron(II) complex in avidin

Voltaire G. Organo, Wanhua Ye, Prakhar K. Agarwal, Elena V. Rybak-Akimova

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

A simple methodology for single-site conjugation of macrocycles and metallomacrocycles with biotin is presented. This method has been used to conjugate a redox-active macrocyclic complex and embed it into avidin. The resulting biotin-metal complex-avidin adduct exhibits peroxidase activity as shown by the oxidation of ABTS and pyrogallol with H2O2.

Original languageEnglish (US)
Pages (from-to)15-21
Number of pages7
JournalJournal of Inclusion Phenomena and Macrocyclic Chemistry
Volume64
Issue number1-2
DOIs
StatePublished - Jun 2009
Externally publishedYes

Keywords

  • Biotinylation
  • Catalysis
  • Macrocycles
  • Metallomacrocycles

ASJC Scopus subject areas

  • Food Science
  • Chemistry(all)
  • Condensed Matter Physics

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