Biomarkers of world trade center particulate matter exposure: Physiology of distal airway and blood biomarkers that predict FEV<inf>1</inf> decline

Michael D. Weiden, Sophia Kwon, Erin Caraher, Kenneth I. Berger, Joan Reibman, William N. Rom, David J. Prezant, Anna Nolan

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Biomarkers can be important predictors of disease severity and progression. The intense exposure to particulates and other toxins from the destruction of the World Trade Center (WTC) overwhelmed the lung's normal protective barriers. The Fire Department of New York (FDNY) cohort not only had baseline pre-exposure lung function measures but also had serum samples banked soon after their WTC exposure. This well-phenotyped group of highly exposed first responders is an ideal cohort for biomarker discovery and eventual validation. Disease progression was heterogeneous in this group in that some individuals subsequently developed abnormal lung function while others recovered. Airflow obstruction predominated in WTC-exposed patients who were symptomatic. Multiple independent disease pathways may cause this abnormal FEV<inf>1</inf> after irritant exposure. WTC exposure activates one or more of these pathways causing abnormal FEV<inf>1</inf> in an individual. Our hypothesis was that serum biomarkers expressed within 6 months after WTC exposure reflect active disease pathways and predict subsequent development or protection from abnormal FEV<inf>1</inf> below the lower limit of normal known as WTC-Lung Injury (WTC-LI). We utilized a nested case-cohort control design of previously healthy never smokers who sought subspecialty pulmonary evaluation to explore predictive biomarkers of WTC-LI. We have identified biomarkers of inflammation, metabolic derangement, protease/antiprotease balance, and vascular injury expressed in serum within 6 months of WTC exposure that were predictive of their FEV<inf>1</inf> up to 7 years after their WTC exposure. Predicting future risk of airway injury after particulate exposures can focus monitoring and early treatment on a subset of patients in greatest need of these services.

Original languageEnglish (US)
Pages (from-to)323-333
Number of pages11
JournalSeminars in Respiratory and Critical Care Medicine
Volume36
Issue number3
DOIs
StatePublished - Jun 1 2015

Fingerprint

Particulate Matter
Biomarkers
Lung
Disease Progression
Serum
Irritants
Vascular System Injuries
Lung Injury
Protease Inhibitors
Peptide Hydrolases
Inflammation
Wounds and Injuries

Keywords

  • lung injury
  • obstructive airway disease
  • predictive biomarkers
  • World Trade Center

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

Cite this

Biomarkers of world trade center particulate matter exposure : Physiology of distal airway and blood biomarkers that predict FEV<inf>1</inf> decline. / Weiden, Michael D.; Kwon, Sophia; Caraher, Erin; Berger, Kenneth I.; Reibman, Joan; Rom, William N.; Prezant, David J.; Nolan, Anna.

In: Seminars in Respiratory and Critical Care Medicine, Vol. 36, No. 3, 01.06.2015, p. 323-333.

Research output: Contribution to journalArticle

Weiden, Michael D. ; Kwon, Sophia ; Caraher, Erin ; Berger, Kenneth I. ; Reibman, Joan ; Rom, William N. ; Prezant, David J. ; Nolan, Anna. / Biomarkers of world trade center particulate matter exposure : Physiology of distal airway and blood biomarkers that predict FEV<inf>1</inf> decline. In: Seminars in Respiratory and Critical Care Medicine. 2015 ; Vol. 36, No. 3. pp. 323-333.
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