Biomarkers of exposure and effect in a working population exposed to lead, manganese and arsenic

Daniela C. Serrazina, Vanda Lopes De Andrade, Madalena Cota, Maria Luísa Mateus, Michael Aschner, Ana Paula Marreilha dos Santos

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Lead (Pb), manganese (Mn) and arsenic (As) are among the major toxicants in mining environments. Miners are commonly and repeatedly exposed to this toxic mixture. Some adverse effects may appear at concentrations below environmental quality guidelines for individual mixture components. Further, Pb, Mn, and As induce common adverse outcomes, such as interferences in the cholinergic system and heme synthesis. It is thus vital to monitor miners through biomarkers (BM), such that subclinical effects may be identified at an early stage. The main objectives of this study were to evaluate the exposure of a mining population to these three metals and determine alterations in cholinergic and heme synthesis parameters. Blood and urine samples of workers (n = 60) were obtained from a Portuguese mining industry and compared with a control population (n = 80). The levels of the metals were determined in biological samples, as well as urinary heme precursor levels, delta aminolevulinic acid (ALA) and porphyrins, and blood acetylcholinesterase (AChE) activity. The miners exhibited significantly higher values of Pb and As in blood and urine compared to control. In the case of Mn near or slightly higher than limit values were found. Our data show that heme precursors may be used simultaneously with metal levels as BMs for multiple metal exposures on an individual basis, resulting in 94.3% and 95.7% accuracy, respectively, in blood and urine, for subjects correctly identified with respect to occupation. This study also revealed that biological monitoring of this working population regarding metal body burden and heme precursor accumulation is advisable.

Original languageEnglish (US)
Pages (from-to)983-997
Number of pages15
JournalJournal of Toxicology and Environmental Health - Part A: Current Issues
Volume81
Issue number19
DOIs
StatePublished - Oct 2 2018

Fingerprint

Arsenic
Biomarkers
Manganese
Heme
Metals
Miners
Blood
Population
Urine
Cholinergic Agents
Body Burden
Aminolevulinic Acid
Environmental Monitoring
Poisons
Mineral industry
Porphyrins
Acetylcholinesterase
Occupations
Industry
Lead

Keywords

  • combined biomarkers
  • Lead
  • manganese and arsenic co-exposure
  • occupational exposure
  • urine heme precursors

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Biomarkers of exposure and effect in a working population exposed to lead, manganese and arsenic. / Serrazina, Daniela C.; Lopes De Andrade, Vanda; Cota, Madalena; Mateus, Maria Luísa; Aschner, Michael; dos Santos, Ana Paula Marreilha.

In: Journal of Toxicology and Environmental Health - Part A: Current Issues, Vol. 81, No. 19, 02.10.2018, p. 983-997.

Research output: Contribution to journalArticle

Serrazina, Daniela C. ; Lopes De Andrade, Vanda ; Cota, Madalena ; Mateus, Maria Luísa ; Aschner, Michael ; dos Santos, Ana Paula Marreilha. / Biomarkers of exposure and effect in a working population exposed to lead, manganese and arsenic. In: Journal of Toxicology and Environmental Health - Part A: Current Issues. 2018 ; Vol. 81, No. 19. pp. 983-997.
@article{e2b793feff2b4089a478df9b1c939d62,
title = "Biomarkers of exposure and effect in a working population exposed to lead, manganese and arsenic",
abstract = "Lead (Pb), manganese (Mn) and arsenic (As) are among the major toxicants in mining environments. Miners are commonly and repeatedly exposed to this toxic mixture. Some adverse effects may appear at concentrations below environmental quality guidelines for individual mixture components. Further, Pb, Mn, and As induce common adverse outcomes, such as interferences in the cholinergic system and heme synthesis. It is thus vital to monitor miners through biomarkers (BM), such that subclinical effects may be identified at an early stage. The main objectives of this study were to evaluate the exposure of a mining population to these three metals and determine alterations in cholinergic and heme synthesis parameters. Blood and urine samples of workers (n = 60) were obtained from a Portuguese mining industry and compared with a control population (n = 80). The levels of the metals were determined in biological samples, as well as urinary heme precursor levels, delta aminolevulinic acid (ALA) and porphyrins, and blood acetylcholinesterase (AChE) activity. The miners exhibited significantly higher values of Pb and As in blood and urine compared to control. In the case of Mn near or slightly higher than limit values were found. Our data show that heme precursors may be used simultaneously with metal levels as BMs for multiple metal exposures on an individual basis, resulting in 94.3{\%} and 95.7{\%} accuracy, respectively, in blood and urine, for subjects correctly identified with respect to occupation. This study also revealed that biological monitoring of this working population regarding metal body burden and heme precursor accumulation is advisable.",
keywords = "combined biomarkers, Lead, manganese and arsenic co-exposure, occupational exposure, urine heme precursors",
author = "Serrazina, {Daniela C.} and {Lopes De Andrade}, Vanda and Madalena Cota and Mateus, {Maria Lu{\'i}sa} and Michael Aschner and {dos Santos}, {Ana Paula Marreilha}",
year = "2018",
month = "10",
day = "2",
doi = "10.1080/15287394.2018.1509408",
language = "English (US)",
volume = "81",
pages = "983--997",
journal = "Journal of Toxicology and Environmental Health - Part A: Current Issues",
issn = "1528-7394",
publisher = "Taylor and Francis Ltd.",
number = "19",

}

TY - JOUR

T1 - Biomarkers of exposure and effect in a working population exposed to lead, manganese and arsenic

AU - Serrazina, Daniela C.

AU - Lopes De Andrade, Vanda

AU - Cota, Madalena

AU - Mateus, Maria Luísa

AU - Aschner, Michael

AU - dos Santos, Ana Paula Marreilha

PY - 2018/10/2

Y1 - 2018/10/2

N2 - Lead (Pb), manganese (Mn) and arsenic (As) are among the major toxicants in mining environments. Miners are commonly and repeatedly exposed to this toxic mixture. Some adverse effects may appear at concentrations below environmental quality guidelines for individual mixture components. Further, Pb, Mn, and As induce common adverse outcomes, such as interferences in the cholinergic system and heme synthesis. It is thus vital to monitor miners through biomarkers (BM), such that subclinical effects may be identified at an early stage. The main objectives of this study were to evaluate the exposure of a mining population to these three metals and determine alterations in cholinergic and heme synthesis parameters. Blood and urine samples of workers (n = 60) were obtained from a Portuguese mining industry and compared with a control population (n = 80). The levels of the metals were determined in biological samples, as well as urinary heme precursor levels, delta aminolevulinic acid (ALA) and porphyrins, and blood acetylcholinesterase (AChE) activity. The miners exhibited significantly higher values of Pb and As in blood and urine compared to control. In the case of Mn near or slightly higher than limit values were found. Our data show that heme precursors may be used simultaneously with metal levels as BMs for multiple metal exposures on an individual basis, resulting in 94.3% and 95.7% accuracy, respectively, in blood and urine, for subjects correctly identified with respect to occupation. This study also revealed that biological monitoring of this working population regarding metal body burden and heme precursor accumulation is advisable.

AB - Lead (Pb), manganese (Mn) and arsenic (As) are among the major toxicants in mining environments. Miners are commonly and repeatedly exposed to this toxic mixture. Some adverse effects may appear at concentrations below environmental quality guidelines for individual mixture components. Further, Pb, Mn, and As induce common adverse outcomes, such as interferences in the cholinergic system and heme synthesis. It is thus vital to monitor miners through biomarkers (BM), such that subclinical effects may be identified at an early stage. The main objectives of this study were to evaluate the exposure of a mining population to these three metals and determine alterations in cholinergic and heme synthesis parameters. Blood and urine samples of workers (n = 60) were obtained from a Portuguese mining industry and compared with a control population (n = 80). The levels of the metals were determined in biological samples, as well as urinary heme precursor levels, delta aminolevulinic acid (ALA) and porphyrins, and blood acetylcholinesterase (AChE) activity. The miners exhibited significantly higher values of Pb and As in blood and urine compared to control. In the case of Mn near or slightly higher than limit values were found. Our data show that heme precursors may be used simultaneously with metal levels as BMs for multiple metal exposures on an individual basis, resulting in 94.3% and 95.7% accuracy, respectively, in blood and urine, for subjects correctly identified with respect to occupation. This study also revealed that biological monitoring of this working population regarding metal body burden and heme precursor accumulation is advisable.

KW - combined biomarkers

KW - Lead

KW - manganese and arsenic co-exposure

KW - occupational exposure

KW - urine heme precursors

UR - http://www.scopus.com/inward/record.url?scp=85054576533&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85054576533&partnerID=8YFLogxK

U2 - 10.1080/15287394.2018.1509408

DO - 10.1080/15287394.2018.1509408

M3 - Article

C2 - 30296394

AN - SCOPUS:85054576533

VL - 81

SP - 983

EP - 997

JO - Journal of Toxicology and Environmental Health - Part A: Current Issues

JF - Journal of Toxicology and Environmental Health - Part A: Current Issues

SN - 1528-7394

IS - 19

ER -