Biomarcadores en la medicina cardiovascular

Translated title of the contribution: Biomarkers in Cardiovascular Medicine

José L. Martín-Ventura, Luis M. Blanco-Colio, José Tuñón, Begoña Muñoz-García, Julio Madrigal-Matute, Juan A. Moreno, Melina Vega De Céniga, Jesús Egido

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Cardiovascular disease is the principal cause of death in developed countries. The underlying pathological process is arterial wall thickening due to the formation of atherosclerotic plaque, which is frequently complicated by thrombus, thereby giving rise to the possibility of acute coronary syndrome or stroke. One of the major challenges in cardiovascular medicine is to find a way of predicting the risk that an individual will suffer an acute thrombotic event. During the last few decades, there has been considerable interest in finding diagnostic and prognostic biomarkers that can be detected in blood. Of these, C-reactive protein is the best known. Others, such as the soluble CD40 ligand, can be used to predict cardiovascular events. However, to date, no biomarker has been generally accepted for use in clinical practice. At present, there are a number of high-performance techniques, such as proteomics, that have the ability to detect multiple potential biomarkers. In the near future, these approaches may lead to the discovery of new biomarkers that, when used with imaging techniques, could help improve our ability to predict the occurrence of acute vascular events.

Original languageSpanish
Pages (from-to)677-688
Number of pages12
JournalRevista Espanola de Cardiologia
Volume62
Issue number6
DOIs
StatePublished - Jun 2009
Externally publishedYes

Fingerprint

Biomarkers
Medicine
CD40 Ligand
Atherosclerotic Plaques
Pathologic Processes
Acute Coronary Syndrome
Developed Countries
C-Reactive Protein
Proteomics
Blood Vessels
Cause of Death
Thrombosis
Cardiovascular Diseases
Stroke

Keywords

  • Atherothrombosis
  • Biomarkers
  • Proteomics

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Martín-Ventura, J. L., Blanco-Colio, L. M., Tuñón, J., Muñoz-García, B., Madrigal-Matute, J., Moreno, J. A., ... Egido, J. (2009). Biomarcadores en la medicina cardiovascular. Revista Espanola de Cardiologia, 62(6), 677-688. https://doi.org/10.1016/S0300-8932(09)71335-1

Biomarcadores en la medicina cardiovascular. / Martín-Ventura, José L.; Blanco-Colio, Luis M.; Tuñón, José; Muñoz-García, Begoña; Madrigal-Matute, Julio; Moreno, Juan A.; Vega De Céniga, Melina; Egido, Jesús.

In: Revista Espanola de Cardiologia, Vol. 62, No. 6, 06.2009, p. 677-688.

Research output: Contribution to journalArticle

Martín-Ventura, JL, Blanco-Colio, LM, Tuñón, J, Muñoz-García, B, Madrigal-Matute, J, Moreno, JA, Vega De Céniga, M & Egido, J 2009, 'Biomarcadores en la medicina cardiovascular', Revista Espanola de Cardiologia, vol. 62, no. 6, pp. 677-688. https://doi.org/10.1016/S0300-8932(09)71335-1
Martín-Ventura JL, Blanco-Colio LM, Tuñón J, Muñoz-García B, Madrigal-Matute J, Moreno JA et al. Biomarcadores en la medicina cardiovascular. Revista Espanola de Cardiologia. 2009 Jun;62(6):677-688. https://doi.org/10.1016/S0300-8932(09)71335-1
Martín-Ventura, José L. ; Blanco-Colio, Luis M. ; Tuñón, José ; Muñoz-García, Begoña ; Madrigal-Matute, Julio ; Moreno, Juan A. ; Vega De Céniga, Melina ; Egido, Jesús. / Biomarcadores en la medicina cardiovascular. In: Revista Espanola de Cardiologia. 2009 ; Vol. 62, No. 6. pp. 677-688.
@article{97fe45cb52af4c8d8c58eca01d44f86b,
title = "Biomarcadores en la medicina cardiovascular",
abstract = "Cardiovascular disease is the principal cause of death in developed countries. The underlying pathological process is arterial wall thickening due to the formation of atherosclerotic plaque, which is frequently complicated by thrombus, thereby giving rise to the possibility of acute coronary syndrome or stroke. One of the major challenges in cardiovascular medicine is to find a way of predicting the risk that an individual will suffer an acute thrombotic event. During the last few decades, there has been considerable interest in finding diagnostic and prognostic biomarkers that can be detected in blood. Of these, C-reactive protein is the best known. Others, such as the soluble CD40 ligand, can be used to predict cardiovascular events. However, to date, no biomarker has been generally accepted for use in clinical practice. At present, there are a number of high-performance techniques, such as proteomics, that have the ability to detect multiple potential biomarkers. In the near future, these approaches may lead to the discovery of new biomarkers that, when used with imaging techniques, could help improve our ability to predict the occurrence of acute vascular events.",
keywords = "Atherothrombosis, Biomarkers, Proteomics",
author = "Mart{\'i}n-Ventura, {Jos{\'e} L.} and Blanco-Colio, {Luis M.} and Jos{\'e} Tu{\~n}{\'o}n and Bego{\~n}a Mu{\~n}oz-Garc{\'i}a and Julio Madrigal-Matute and Moreno, {Juan A.} and {Vega De C{\'e}niga}, Melina and Jes{\'u}s Egido",
year = "2009",
month = "6",
doi = "10.1016/S0300-8932(09)71335-1",
language = "Spanish",
volume = "62",
pages = "677--688",
journal = "Revista Espanola de Cardiologia",
issn = "0300-8932",
publisher = "Ediciones Doyma, S.L.",
number = "6",

}

TY - JOUR

T1 - Biomarcadores en la medicina cardiovascular

AU - Martín-Ventura, José L.

AU - Blanco-Colio, Luis M.

AU - Tuñón, José

AU - Muñoz-García, Begoña

AU - Madrigal-Matute, Julio

AU - Moreno, Juan A.

AU - Vega De Céniga, Melina

AU - Egido, Jesús

PY - 2009/6

Y1 - 2009/6

N2 - Cardiovascular disease is the principal cause of death in developed countries. The underlying pathological process is arterial wall thickening due to the formation of atherosclerotic plaque, which is frequently complicated by thrombus, thereby giving rise to the possibility of acute coronary syndrome or stroke. One of the major challenges in cardiovascular medicine is to find a way of predicting the risk that an individual will suffer an acute thrombotic event. During the last few decades, there has been considerable interest in finding diagnostic and prognostic biomarkers that can be detected in blood. Of these, C-reactive protein is the best known. Others, such as the soluble CD40 ligand, can be used to predict cardiovascular events. However, to date, no biomarker has been generally accepted for use in clinical practice. At present, there are a number of high-performance techniques, such as proteomics, that have the ability to detect multiple potential biomarkers. In the near future, these approaches may lead to the discovery of new biomarkers that, when used with imaging techniques, could help improve our ability to predict the occurrence of acute vascular events.

AB - Cardiovascular disease is the principal cause of death in developed countries. The underlying pathological process is arterial wall thickening due to the formation of atherosclerotic plaque, which is frequently complicated by thrombus, thereby giving rise to the possibility of acute coronary syndrome or stroke. One of the major challenges in cardiovascular medicine is to find a way of predicting the risk that an individual will suffer an acute thrombotic event. During the last few decades, there has been considerable interest in finding diagnostic and prognostic biomarkers that can be detected in blood. Of these, C-reactive protein is the best known. Others, such as the soluble CD40 ligand, can be used to predict cardiovascular events. However, to date, no biomarker has been generally accepted for use in clinical practice. At present, there are a number of high-performance techniques, such as proteomics, that have the ability to detect multiple potential biomarkers. In the near future, these approaches may lead to the discovery of new biomarkers that, when used with imaging techniques, could help improve our ability to predict the occurrence of acute vascular events.

KW - Atherothrombosis

KW - Biomarkers

KW - Proteomics

UR - http://www.scopus.com/inward/record.url?scp=67650757181&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67650757181&partnerID=8YFLogxK

U2 - 10.1016/S0300-8932(09)71335-1

DO - 10.1016/S0300-8932(09)71335-1

M3 - Article

C2 - 19480764

AN - SCOPUS:67650757181

VL - 62

SP - 677

EP - 688

JO - Revista Espanola de Cardiologia

JF - Revista Espanola de Cardiologia

SN - 0300-8932

IS - 6

ER -