Biomarkers for CNS involvement in pediatric lupus

Tamar B. Rubinstein; Chaim Putterman; Beatrice Goilav

doi:10.2217/bmm.15.26

Biomarkers for CNS involvement in pediatric lupus

Tamar B. Rubinstein, Chaim Putterman, Beatrice Goilav

Research output: Contribution to journal › Review article › peer-review

7 Scopus citations

Abstract

CNS disease, or central neuropsychiatric lupus erythematosus (cNPSLE), occurs frequently in pediatric lupus, leading to significant morbidity and poor long-term outcomes. Diagnosing cNPSLE is especially difficult in pediatrics; many current diagnostic tools are invasive and/or costly, and there are no current accepted screening mechanisms. The most complicated aspect of diagnosis is differentiating primary disease from other etiologies; research to discover new biomarkers is attempting to address this dilemma. With many mechanisms involved in the pathogenesis of cNPSLE, biomarker profiles across several modalities (molecular, psychometric and neuroimaging) will need to be used. For the care of children with lupus, the challenge will be to develop biomarkers that are accessible by noninvasive measures and reliable in a pediatric population.

Original language	English (US)
Pages (from-to)	545-558
Number of pages	14
Journal	Biomarkers in Medicine
Volume	9
Issue number	6
DOIs	https://doi.org/10.2217/bmm.15.26
State	Published - Jun 1 2015

Keywords

CNS
biomarkers
neuropsychiatric
pediatric
systemic lupus erythematosus

ASJC Scopus subject areas

Drug Discovery
Clinical Biochemistry
Biochemistry, medical

Access to Document

10.2217/bmm.15.26

Cite this

@article{8722dbb55a474f98a7a6ceaa4a18f5df,

title = "Biomarkers for CNS involvement in pediatric lupus",

abstract = "CNS disease, or central neuropsychiatric lupus erythematosus (cNPSLE), occurs frequently in pediatric lupus, leading to significant morbidity and poor long-term outcomes. Diagnosing cNPSLE is especially difficult in pediatrics; many current diagnostic tools are invasive and/or costly, and there are no current accepted screening mechanisms. The most complicated aspect of diagnosis is differentiating primary disease from other etiologies; research to discover new biomarkers is attempting to address this dilemma. With many mechanisms involved in the pathogenesis of cNPSLE, biomarker profiles across several modalities (molecular, psychometric and neuroimaging) will need to be used. For the care of children with lupus, the challenge will be to develop biomarkers that are accessible by noninvasive measures and reliable in a pediatric population.",

keywords = "CNS, biomarkers, neuropsychiatric, pediatric, systemic lupus erythematosus",

author = "Rubinstein, {Tamar B.} and Chaim Putterman and Beatrice Goilav",

note = "Publisher Copyright: {\textcopyright} 2015 Future Medicine Ltd.",

year = "2015",

month = jun,

day = "1",

doi = "10.2217/bmm.15.26",

language = "English (US)",

volume = "9",

pages = "545--558",

journal = "Biomarkers in Medicine",

issn = "1752-0363",

publisher = "Future Medicine Ltd.",

number = "6",

}

TY - JOUR

T1 - Biomarkers for CNS involvement in pediatric lupus

AU - Rubinstein, Tamar B.

AU - Putterman, Chaim

AU - Goilav, Beatrice

PY - 2015/6/1

Y1 - 2015/6/1

N2 - CNS disease, or central neuropsychiatric lupus erythematosus (cNPSLE), occurs frequently in pediatric lupus, leading to significant morbidity and poor long-term outcomes. Diagnosing cNPSLE is especially difficult in pediatrics; many current diagnostic tools are invasive and/or costly, and there are no current accepted screening mechanisms. The most complicated aspect of diagnosis is differentiating primary disease from other etiologies; research to discover new biomarkers is attempting to address this dilemma. With many mechanisms involved in the pathogenesis of cNPSLE, biomarker profiles across several modalities (molecular, psychometric and neuroimaging) will need to be used. For the care of children with lupus, the challenge will be to develop biomarkers that are accessible by noninvasive measures and reliable in a pediatric population.

AB - CNS disease, or central neuropsychiatric lupus erythematosus (cNPSLE), occurs frequently in pediatric lupus, leading to significant morbidity and poor long-term outcomes. Diagnosing cNPSLE is especially difficult in pediatrics; many current diagnostic tools are invasive and/or costly, and there are no current accepted screening mechanisms. The most complicated aspect of diagnosis is differentiating primary disease from other etiologies; research to discover new biomarkers is attempting to address this dilemma. With many mechanisms involved in the pathogenesis of cNPSLE, biomarker profiles across several modalities (molecular, psychometric and neuroimaging) will need to be used. For the care of children with lupus, the challenge will be to develop biomarkers that are accessible by noninvasive measures and reliable in a pediatric population.

KW - CNS

KW - biomarkers

KW - neuropsychiatric

KW - pediatric

KW - systemic lupus erythematosus

UR - http://www.scopus.com/inward/record.url?scp=84931307705&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84931307705&partnerID=8YFLogxK

U2 - 10.2217/bmm.15.26

DO - 10.2217/bmm.15.26

M3 - Review article

C2 - 26079959

AN - SCOPUS:84931307705

VL - 9

SP - 545

EP - 558

JO - Biomarkers in Medicine

JF - Biomarkers in Medicine

SN - 1752-0363

IS - 6

ER -

Biomarkers for CNS involvement in pediatric lupus

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this