Biomarker-driven targeted therapies for gastric/gastro-esophageal junction malignancies

Salem Kim, Afsaneh Barzi, Lakshmi Rajdev

Research output: Contribution to journalArticle

Abstract

Gastroesophageal malignancies often contain high amounts of genetic and molecular alterations that result in an aggressive disease capable of rapidly metastasizing to distant organs and early development of drug resistance. Most patients in the Western hemisphere present with locally advanced or metastatic disease that is treated with systemic chemotherapy used either in the neoadjuvant or palliative setting, respectively. This article will review the various recent advances in the development of targeted therapies for the treatment of advanced gastric and gastroesophageal cancer.

Original languageEnglish (US)
JournalSeminars in Oncology
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Stomach
Biomarkers
Drug Resistance
Stomach Neoplasms
Molecular Biology
Neoplasms
Drug Therapy
Therapeutics

Keywords

  • Gastric adenocarcinoma
  • Gastric cancer
  • Gastroesophageal adenocarcinoma

ASJC Scopus subject areas

  • Hematology
  • Oncology

Cite this

Biomarker-driven targeted therapies for gastric/gastro-esophageal junction malignancies. / Kim, Salem; Barzi, Afsaneh; Rajdev, Lakshmi.

In: Seminars in Oncology, 01.01.2018.

Research output: Contribution to journalArticle

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