TY - JOUR
T1 - Biology of gait control
T2 - Vitamin D involvement
AU - Beauchet, O.
AU - Annweiler, C.
AU - Verghese, J.
AU - Fantino, B.
AU - Herrmann, F. R.
AU - Allali, G.
N1 - Funding Information:
Study funding: Supported by the Swiss National Science Foundation (No. 33CM30-124115 to G.A.).
Funding Information:
Prof. Beauchet serves on the editorial board of Annales de Gérontologie and serves as a consultant for the Korian Group. Dr. Annweiler serves as a consultant for Ipsen. Dr. Verghese has served on the speakers' bureau for Pfizer Inc and receives research support from the NIH/NIA, the American Federation of Aging Research, and the Donald W Reynolds Foundation. Dr. Fantino reports no disclosures. Dr. Herrmann serves on editorial advisory boards for Current Gerontology and Geriatrics Research, European Geriatrics Medicine, and Annales de Gérontologie. Dr. Allali has received research support from the Swiss National Science Foundation.
PY - 2011/5/10
Y1 - 2011/5/10
N2 - Background: Adverse neuromuscular events have been described in case of low serum 25-hydroxyvitamin D (25OHD) concentrations, suggesting that vitamin D may be involved in gait stability. The objective of this cross-sectional study was to examine the association between stride-to-stride variability of stride time (STV) and serum 25OHD concentration in adults aged 65 years and older. Methods: STV and 25OHD concentration were assessed in 411 community-dwelling older adults (mean age 70.4 ± 1.8 years, 57.9% women). The following established 25OHD thresholds were used: severe 25OHD insufficiency <10 ng/mL, moderate 10-30 ng/mL, and normal >30 ng/mL. Age, number of drugs used per day, use of psychoactive drugs, depressive symptoms, cognitive decline, history of falls, distance visual acuity, lower limb proprioception, center of mass (CoM) motion, and walking speed were considered as potential confounders. Results: A total of 16.6% (n = 68) of subjects had severe 25OHD insufficiency, 70.3% (n = 289) moderate insufficiency, and 13.1% (n = 54) normal concentrations. In the full adjusted and the stepwise backward linear regression models, high STV (worse performance) was associated with severe 25OHD insufficiency (p = 0.028 and p = 0.044, respectively), high CoM motion (p = 0.031 and p = 0.014, respectively), and low lower limb proprioception score (p = 0.017 and p = 0.008, respectively). The stepwise backward regression model also showed that high STV was associated with female gender (p = 0.041). Conclusions: Low serum 25OHD concentrations were associated with high STV reflecting a disturbed gait control. This association could be explained by a possible action of vitamin D on different components involved in gait control.
AB - Background: Adverse neuromuscular events have been described in case of low serum 25-hydroxyvitamin D (25OHD) concentrations, suggesting that vitamin D may be involved in gait stability. The objective of this cross-sectional study was to examine the association between stride-to-stride variability of stride time (STV) and serum 25OHD concentration in adults aged 65 years and older. Methods: STV and 25OHD concentration were assessed in 411 community-dwelling older adults (mean age 70.4 ± 1.8 years, 57.9% women). The following established 25OHD thresholds were used: severe 25OHD insufficiency <10 ng/mL, moderate 10-30 ng/mL, and normal >30 ng/mL. Age, number of drugs used per day, use of psychoactive drugs, depressive symptoms, cognitive decline, history of falls, distance visual acuity, lower limb proprioception, center of mass (CoM) motion, and walking speed were considered as potential confounders. Results: A total of 16.6% (n = 68) of subjects had severe 25OHD insufficiency, 70.3% (n = 289) moderate insufficiency, and 13.1% (n = 54) normal concentrations. In the full adjusted and the stepwise backward linear regression models, high STV (worse performance) was associated with severe 25OHD insufficiency (p = 0.028 and p = 0.044, respectively), high CoM motion (p = 0.031 and p = 0.014, respectively), and low lower limb proprioception score (p = 0.017 and p = 0.008, respectively). The stepwise backward regression model also showed that high STV was associated with female gender (p = 0.041). Conclusions: Low serum 25OHD concentrations were associated with high STV reflecting a disturbed gait control. This association could be explained by a possible action of vitamin D on different components involved in gait control.
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U2 - 10.1212/WNL.0b013e318219fb08
DO - 10.1212/WNL.0b013e318219fb08
M3 - Article
C2 - 21471466
AN - SCOPUS:79955789950
SN - 0028-3878
VL - 76
SP - 1617
EP - 1622
JO - Neurology
JF - Neurology
IS - 19
ER -