Biology of eating behavior in obesity.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Understanding normal and dysfunctional energy regulation and body weight regulation requires neural evaluation of the signals involved in the control of food intake within a meal, as well as signals related to the availability of stored fuels. Work from our laboratory has focused on peripheral and central nervous system studies of behavior and physiology designed to improve our understanding of the role of gut-brain communication in the control of food intake and energy homeostasis. Gastrointestinal administration of nutrients reduces subsequent meal size, suggesting a potent role for peripheral nutrient sensing in the negative feedback control of ingestion. Vagal afferent nerves supply gastrointestinal sites stimulated during food intake, and these nerves are responsive to mechanical and nutrient chemical properties of ingested food. In addition, the presence of nutrients in these gastrointestinal sites stimulates the release of peptides that affect energy intake. These gut peptides also modulate the activity of peripheral gastrointestinal sensory nerves in ways that may contribute to their effects on food intake. In the central nervous system, adiposity hormones and their downstream mediators have been shown to work at both hindbrain and forebrain sites to affect food intake and metabolism. Importantly, recent data has shown that adiposity hormones acting in the brain increase the behavioral and neural potency of feeding inhibitory gastrointestinal stimuli. These data support the suggestion that insensitivity to adiposity hormones in obesity may be characterized by alterations in their ability to modulate the neural processing of food signals important in determining how much food is consumed during a meal.

Original languageEnglish (US)
JournalObesity Research
Volume12 Suppl 2
StatePublished - Nov 2004
Externally publishedYes

Fingerprint

Feeding Behavior
eating habits
food intake
obesity
Obesity
Eating
adiposity
Food
Biological Sciences
Adiposity
brain
nerve tissue
Meals
hormones
nutrients
central nervous system
Hormones
digestive system
peptides
Central Nervous System

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Public Health, Environmental and Occupational Health
  • Endocrinology
  • Food Science
  • Endocrinology, Diabetes and Metabolism

Cite this

Biology of eating behavior in obesity. / Schwartz, Gary J.

In: Obesity Research, Vol. 12 Suppl 2, 11.2004.

Research output: Contribution to journalArticle

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