Abstract
Osteosarcoma is the most common malignant bone tumor in children and adolescents. Survival for these patients was poor with the use of surgery and/or radiotherapy. The introduction of multi-agent chemotherapy dramatically improved the outcome for these patients and the majority of modern series report 3-year disease-free survival of 60%-70%. This paper describes current strategies for treating patients with osteosarcoma as well as review of the clinical features, radiologic and diagnostic work-up, and pathology. The authors review the state of the art management for patients with osteosarcoma in North America and Europe including the use of limb-salvage procedures and reconstruction as well as discuss the etiologic and biologic factors associated with tumor development. Therapy-related sequelae and future directions in the biology and therapy for these patients are also discussed.
Original language | English (US) |
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Pages (from-to) | 422-441 |
Number of pages | 20 |
Journal | Oncologist |
Volume | 9 |
Issue number | 4 |
DOIs | |
State | Published - 2004 |
Externally published | Yes |
Keywords
- Biology
- Multidisciplinary treatment
- Pediatric osteosarcoma
- Therapeutic advances
- Therapy
ASJC Scopus subject areas
- Oncology
- Cancer Research