TY - JOUR
T1 - Biological variability of lipoproteins and apolipoproteins in patients referred to a lipid clinic
AU - Kafonek, Stephanie D.
AU - Derby, Carol A.
AU - Bachorik, Paul S.
PY - 1992
Y1 - 1992
N2 - We determined the physiological variability of total cholesterol, high- (HDL) and low-density lipoprotein (LDL) cholesterol, triglycerides, and apolipoproteins A-l and B in fasting blood samples from patients referred to the Johns Hopkins Lipid Referral Clinic. Samples were taken on each of three occasions during baseline evaluation visits before the patients were treated. The median physiological coefficients of variation (CVP) were as follows: total cholesterol, 5.0%; triglycerides, 17.8%; HDL cholesterol, 7.1%; LDL cholesterol, calculated from the previous three measurements, 7.8%; and apolipoproteins A-l and B, 7.1% and 6.4%, respectively. There were no significant differences in CVp between children (≤18 years) and adults (>18 years) for any of the measurements. On the basis of our findings, single measurements in serial samples taken on three occasions suffice to establish the patients' usual values with the following precisions (± 1 CV): total cholesterol, ± 4%; triglycerides, ± 11%; HDL cholesterol, ± 8%; LDL cholesterol, ± 6%; and apolipo-proteins A-l and B, ± 7%.
AB - We determined the physiological variability of total cholesterol, high- (HDL) and low-density lipoprotein (LDL) cholesterol, triglycerides, and apolipoproteins A-l and B in fasting blood samples from patients referred to the Johns Hopkins Lipid Referral Clinic. Samples were taken on each of three occasions during baseline evaluation visits before the patients were treated. The median physiological coefficients of variation (CVP) were as follows: total cholesterol, 5.0%; triglycerides, 17.8%; HDL cholesterol, 7.1%; LDL cholesterol, calculated from the previous three measurements, 7.8%; and apolipoproteins A-l and B, 7.1% and 6.4%, respectively. There were no significant differences in CVp between children (≤18 years) and adults (>18 years) for any of the measurements. On the basis of our findings, single measurements in serial samples taken on three occasions suffice to establish the patients' usual values with the following precisions (± 1 CV): total cholesterol, ± 4%; triglycerides, ± 11%; HDL cholesterol, ± 8%; LDL cholesterol, ± 6%; and apolipo-proteins A-l and B, ± 7%.
KW - Baseline values
KW - Cholesterol
KW - Intra-individual variation
KW - Screening
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U2 - 10.1093/clinchem/38.6.864
DO - 10.1093/clinchem/38.6.864
M3 - Article
C2 - 1597012
AN - SCOPUS:0026875062
SN - 0009-9147
VL - 38
SP - 864
EP - 872
JO - Clinical chemistry
JF - Clinical chemistry
IS - 6
ER -