Biological approaches to mechanistically understand the healthy life span extension achieved by calorie restriction and modulation of hormones

Nir Barzilai, Andrzej Bartke

Research output: Contribution to journalArticle

57 Scopus citations


Calorie restriction and reduced somatotropic (growth hormone and insulin-like growth factor-1) signaling have a widespread though not universal ability to extend life. These interventions are considered central tools to understanding the downstream events that lead to the increase in healthy life span. As these approaches have been validated, the animals phenotyped, and the mechanisms proposed, many challenges have emerged. In this article, we give several examples and propose several considerations, opportunities, and approaches that may identify major mechanisms through which these interventions exert their effects, and which may lead to drug therapy to increase "health span.".

Original languageEnglish (US)
Pages (from-to)187-191
Number of pages5
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Issue number2
StatePublished - Feb 1 2009



  • Caloric restriction
  • Growth hormone
  • Healthylife span
  • Insolin-like growth fact

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

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