TY - JOUR
T1 - Biological approaches to mechanistically understand the healthy life span extension achieved by calorie restriction and modulation of hormones
AU - Barzilai, Nir
AU - Bartke, Andrzej
PY - 2009/2
Y1 - 2009/2
N2 - Calorie restriction and reduced somatotropic (growth hormone and insulin-like growth factor-1) signaling have a widespread though not universal ability to extend life. These interventions are considered central tools to understanding the downstream events that lead to the increase in healthy life span. As these approaches have been validated, the animals phenotyped, and the mechanisms proposed, many challenges have emerged. In this article, we give several examples and propose several considerations, opportunities, and approaches that may identify major mechanisms through which these interventions exert their effects, and which may lead to drug therapy to increase "health span.".
AB - Calorie restriction and reduced somatotropic (growth hormone and insulin-like growth factor-1) signaling have a widespread though not universal ability to extend life. These interventions are considered central tools to understanding the downstream events that lead to the increase in healthy life span. As these approaches have been validated, the animals phenotyped, and the mechanisms proposed, many challenges have emerged. In this article, we give several examples and propose several considerations, opportunities, and approaches that may identify major mechanisms through which these interventions exert their effects, and which may lead to drug therapy to increase "health span.".
KW - Caloric restriction
KW - Growth hormone
KW - Healthylife span
KW - Insolin-like growth fact
UR - http://www.scopus.com/inward/record.url?scp=64949184038&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=64949184038&partnerID=8YFLogxK
U2 - 10.1093/gerona/gln061
DO - 10.1093/gerona/gln061
M3 - Article
C2 - 19228789
AN - SCOPUS:64949184038
SN - 1079-5006
VL - 64
SP - 187
EP - 191
JO - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
JF - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
IS - 2
ER -