Bioinformatics in otolaryngology research. Part two: Other high-throughput platforms in genomics and epigenetics

T. J. Ow, K. Upadhyay, T. J. Belbin, M. B. Prystowsky, H. Ostrer, R. V. Smith

Research output: Contribution to journalReview article

1 Scopus citations

Abstract

Objectives: This second segment of the two-part review summarises several modern high-throughput methods in genomics, epigenetics and molecular biology. Many principles from nucleotide sequencing and transcriptomics can be applied to other high-throughput molecular biology techniques. Specifically, this manuscript reviews: array comparative genome hybridisation; single nucleotide polymorphism arrays; microarray technology, used to study epigenetics; and methodology applied in proteomics. Finally, the review describes current methods for the integration of multiple molecular biology platforms. Conclusion: Progress in treating human disease in general will require close collaboration with experts in bioinformatics. Improved understanding, by clinicians and physician-scientists in our field, of the concepts presented in both parts of this review will advance diagnosis and therapy for diseases of the head and neck.

Original languageEnglish (US)
Pages (from-to)942-947
Number of pages6
JournalJournal of Laryngology and Otology
Volume128
Issue number11
DOIs
StatePublished - Nov 20 2014

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Keywords

  • Bioinformatics
  • Comparative Genomic Hybridization
  • DNA Methylation
  • Epigenomics
  • Otolaryngology
  • Polymorphism
  • Proteomics
  • Single Nucleotide

ASJC Scopus subject areas

  • Otorhinolaryngology

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