Bioinformatics analysis: Gene fusion

Meena Kishore Sakharkar, Yiting Yu, Pandjassarame Kangueane

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Gene fusion is an important evolutionary phenomenon. Human fusion proteins consisting of two or more fusion partners of bacterial origin exhibit accreted (enhanced or novel) function. These proteins mimic operons, simulate protein subunit interfaces in bacteria, exhibit multiple functions, and show alternative splicing in humans. They are also associated with metabolites having greater connectivity in complex networks.

Original languageEnglish (US)
Title of host publicationBioinformatics
Subtitle of host publicationA Concept-Based Introduction
PublisherSpringer US
Pages175-181
Number of pages7
ISBN (Print)9783540241669
DOIs
StatePublished - Dec 1 2007

Keywords

  • Domain
  • Evolution
  • Fusion protein
  • Gene fusion

ASJC Scopus subject areas

  • Computer Science(all)

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  • Cite this

    Sakharkar, M. K., Yu, Y., & Kangueane, P. (2007). Bioinformatics analysis: Gene fusion. In Bioinformatics: A Concept-Based Introduction (pp. 175-181). Springer US. https://doi.org/10.1007/978-0-387-84870-9_14