TY - JOUR
T1 - Bioengineering paradigms for cell migration in confined microenvironments
AU - Stroka, Kimberly M.
AU - Gu, Zhizhan
AU - Sun, Sean X.
AU - Konstantopoulos, Konstantinos
N1 - Funding Information:
This work was supported by awards from the National Science Foundation ( NSF-1159823 to KK), National Cancer Institute ( R01-CA186286 to KK, U54-CA143868 to KK, SXS and F32-CA177756 to KMS), and the Kleberg Foundation (to KK, SXS).
PY - 2014/10
Y1 - 2014/10
N2 - Cell migration is a fundamental process underlying diverse (patho)physiological phenomena. The classical understanding of the molecular mechanisms of cell migration has been based on in vitro studies on two-dimensional substrates. More recently, mounting evidence from intravital studies has shown that during metastasis, tumor cells must navigate complex microenvironments in vivo, including narrow, pre-existing microtracks created by anatomical structures. It is becoming apparent that unraveling the mechanisms of confined cell migration in this context requires a multi-disciplinary approach through integration of in vivo and in vitro studies, along with sophisticated bioengineering techniques and mathematical modeling. Here, we highlight such an approach that has led to discovery of a new model for cell migration in confined microenvironments (i.e., the Osmotic Engine Model).
AB - Cell migration is a fundamental process underlying diverse (patho)physiological phenomena. The classical understanding of the molecular mechanisms of cell migration has been based on in vitro studies on two-dimensional substrates. More recently, mounting evidence from intravital studies has shown that during metastasis, tumor cells must navigate complex microenvironments in vivo, including narrow, pre-existing microtracks created by anatomical structures. It is becoming apparent that unraveling the mechanisms of confined cell migration in this context requires a multi-disciplinary approach through integration of in vivo and in vitro studies, along with sophisticated bioengineering techniques and mathematical modeling. Here, we highlight such an approach that has led to discovery of a new model for cell migration in confined microenvironments (i.e., the Osmotic Engine Model).
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U2 - 10.1016/j.ceb.2014.06.001
DO - 10.1016/j.ceb.2014.06.001
M3 - Review article
AN - SCOPUS:84903126149
SN - 0955-0674
VL - 30
SP - 41
EP - 50
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
IS - 1
ER -